Interindividual epigenetic variation in ABCB1 promoter and its relationship with ABCB1 expression and function in healthy Chinese subjects - Wu, Lan‐Xiang; Wen, Chun‐Jie; Li, Ying; Zhang, Xue; Shao, Ying‐Ying; Yang, Zhu; Zhou, Hong‐Hao (British journal of clinical pharmacology, 2015)
Keywords: ABCB1; Acetylation; Adolescent; Adult; Alleles; Asian Continental Ancestry Group - genetics; ATP Binding Cassette Transporter, Sub-Family B - biosynthesis; ATP Binding Cassette Transporter, Sub-Family B - genetics; ATP Binding Cassette Transporter, Sub-Family B - metabolism; digoxin; Digoxin - administration & dosage; Digoxin - blood; Digoxin - pharmacokinetics; DNA Methylation - genetics; Epigenesis, Genetic; epigenetic; Epithelial Cells - metabolism; expression; Genotype; Healthy Volunteers; Histones - metabolism; Humans; interindividual variation; Male; Middle Aged; Pharmacokinetics; Polymorphism, Single Nucleotide; Promoter Regions, Genetic - genetics; RNA, Messenger - analysis; Young Adult; interindividual variation; ABCB1; expression; digoxin; epigenetic