Natural Product Hybrids as New Leads for Drug Discovery

• Published in: Angewandte Chemie International Edition Vol. 42; no. 34; pp. 3996 - 4028
• Main Authors: Tietze, Lutz F., Bell, Hubertus P., Chandrasekhar, Srivari
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 05.09.2003; WILEY‐VCH Verlag
• Subjects: Animals; biological activity; Biological Factors - chemistry; Biological Factors - pharmacology; combinatorial chemistry; Drug Design; Drug Evaluation, Preclinical - methods; Humans; hybrids; Molecular Structure; natural products; Pharmaceutical Preparations - chemical synthesis; Pharmaceutical Preparations - chemistry

Natural products play an important role in the development of drugs, especially for the treatment of infections and cancer, as well as immunosuppressive compounds. However, the number of natural products is limited, whereas millions of hybrids as combinations of parts of different natural products c...