The Effect of Ondansetron on Acute Opioid Tolerance in Patients Receiving Intrathecal Opioids Prior to Cesarean Delivery

• Published in: Regional anesthesia and pain medicine Vol. 42; no. 5; pp. 669 - 673
• Main Authors: Greer, Kevin C, Terkawi, Abdullah S, Tsang, Siny, Singla, Priyanka, Durieux, Marcel E, Tiouririne, Mohamed
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.09.2017
• Subjects: Adult; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - adverse effects; Anesthesia; Anesthesia, Spinal - adverse effects; Anesthesia, Spinal - methods; Cesarean section; Cesarean Section - adverse effects; Double-Blind Method; Drug Tolerance; Elective Surgical Procedures; Female; Fentanyl - administration & dosage; Fentanyl - adverse effects; Humans; Hyperalgesia; Infusions, Intravenous; Injections, Spinal; Linear Models; Narcotics; Ondansetron - administration & dosage; Ondansetron - adverse effects; Pain; Pain Measurement; Pain, Postoperative - diagnosis; Pain, Postoperative - etiology; Pain, Postoperative - physiopathology; Pain, Postoperative - prevention & control; Pregnancy; Prospective Studies; Regional anesthesia; Serotonin Antagonists - administration & dosage; Serotonin Antagonists - adverse effects; Time Factors; Treatment Outcome; Virginia

Multiple animal studies suggest that ondansetron ameliorates opioid-induced hyperalgesia and tolerance. In this study, we aimed to determine if the administration of ondansetron prior to spinal anesthesia would have an effect on intrathecal opioid-induced acute opioid tolerance, postoperative pain,...