Organic Nitrate Metabolism and Action: Toward a Unifying Hypothesis and the Future—A Dedication to Professor Leslie Z. Benet

• Published in: Journal of pharmaceutical sciences Vol. 102; no. 9; pp. 3070 - 3081
• Main Authors: Page, Nathaniel A., Fung, Ho-Leung
• Format: Journal Article
• Language: English
• Published: Hoboken Elsevier Inc 01.09.2013; Wiley Subscription Services, Inc., A Wiley Company; Elsevier Limited
• Subjects: Aldehyde Dehydrogenase - metabolism; Animals; Cytochrome P-450 Enzyme System - metabolism; Enzymology; Glutathione Transferase - metabolism; Humans; Metabolism; Nitrates - metabolism; Nitrates - pharmacology; Nitric Oxide; Nitric Oxide - metabolism; Nitric Oxide - pharmacology; Toxicology; Xanthine Dehydrogenase - metabolism; Toxicology; Nitric Oxide; Enzymology; Metabolism

This review summarizes the major advances that had been reported since the outstanding contributions that Professor Benet and his group had made in the 1980s and 1990s concerning the metabolism and pharmacologic action of organic nitrates (ORNs). Several pivotal studies have now enhanced our underst...