Intracellular marriage of bicarbonate and Mn ions as “immune ion reactors” to regulate redox homeostasis and enhanced antitumor immune responses

• Published in: Journal of nanobiotechnology Vol. 20; no. 1; pp. 193 - 17
• Main Authors: Feng, Yushuo, Liu, Yaqing, Ma, Xiaoqian, Xu, Lihua, Ding, Dandan, Chen, Lei, Wang, Zongzhang, Qin, Ruixue, Sun, Wenjing, Chen, Hongmin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.04.2022; BioMed Central; BMC
• Subjects: Bicarbonates; Bicarbonates - therapeutic use; Biological response modifiers; Cancer; Care and treatment; Cell Line, Tumor; Chemical properties; Health aspects; Homeostasis; Humans; Immune activator; Immune response; Immunity; Immunotherapy; Manganese; Manganese immunotherapy; Metal ions; Methods; Neoplasms - drug therapy; Oncology, Experimental; Orthotopic liver cancer; Oxidation-Reduction; Redox homeostasis; Self-supplying intracellular ions; China; Immune activator; Self-supplying intracellular ions; Orthotopic liver cancer; Manganese immunotherapy; Redox homeostasis

Different from Fe ions in Fenton reaction, Mn ions can function both as catalyst for chemodynamic therapy and immune adjuvant for antitumor immune responses. In Mn-mediated Fenton-like reaction, bicarbonate ([Formula: see text]), as the most important component to amplify therapeutic effects, must b...