The antagonistic relationship between apoptosis and polyploidy in development and cancer

• Published in: Seminars in cell & developmental biology Vol. 156; pp. 35 - 43
• Main Authors: Herriage, Hunter C., Huang, Yi-Ting, Calvi, Brian R.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.03.2024
• Subjects: Aneuploidy; Apoptosis; Apoptosis - genetics; Chromosome Segregation; Endoreplication; Genomic Instability; Humans; Neoplasms - genetics; Polyploidy; Regulated cell death; Tetraploid; PGCC; Polyploidy; devEC; WGD; iEC; Tetraploid; Regulated cell death; Endoreplication; Aneuploidy; CNV; CDK; Apoptosis

One of the important functions of regulated cell death is to prevent cells from inappropriately acquiring extra copies of their genome, a state known as polyploidy. Apoptosis is the primary cell death mechanism that prevents polyploidy, and defects in this apoptotic response can result in polyploid...