The antagonistic relationship between apoptosis and polyploidy in development and cancer

One of the important functions of regulated cell death is to prevent cells from inappropriately acquiring extra copies of their genome, a state known as polyploidy. Apoptosis is the primary cell death mechanism that prevents polyploidy, and defects in this apoptotic response can result in polyploid...

Full description

Saved in:
Bibliographic Details
Published inSeminars in cell & developmental biology Vol. 156; pp. 35 - 43
Main Authors Herriage, Hunter C., Huang, Yi-Ting, Calvi, Brian R.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 15.03.2024
Subjects
Aneuploidy
Apoptosis
Apoptosis - genetics
Chromosome Segregation
Endoreplication
Genomic Instability
Humans
Neoplasms - genetics
Polyploidy
Regulated cell death
Tetraploid
PGCC
Polyploidy
devEC
WGD
iEC
Tetraploid
Regulated cell death
Endoreplication
Aneuploidy
CNV
CDK
Apoptosis
Online AccessGet full text

Cover

Abstract One of the important functions of regulated cell death is to prevent cells from inappropriately acquiring extra copies of their genome, a state known as polyploidy. Apoptosis is the primary cell death mechanism that prevents polyploidy, and defects in this apoptotic response can result in polyploid cells whose subsequent error-prone chromosome segregation are a major contributor to genome instability and cancer progression. Conversely, some cells actively repress apoptosis to become polyploid as part of normal development or regeneration. Thus, although apoptosis prevents polyploidy, the polyploid state can actively repress apoptosis. In this review, we discuss progress in understanding the antagonistic relationship between apoptosis and polyploidy in development and cancer. Despite recent advances, a key conclusion is that much remains unknown about the mechanisms that link apoptosis to polyploid cell cycles. We suggest that drawing parallels between the regulation of apoptosis in development and cancer could help to fill this knowledge gap and lead to more effective therapies.
AbstractList One of the important functions of regulated cell death is to prevent cells from inappropriately acquiring extra copies of their genome, a state known as polyploidy. Apoptosis is the primary cell death mechanism that prevents polyploidy, and defects in this apoptotic response can result in polyploid cells whose subsequent error-prone chromosome segregation are a major contributor to genome instability and cancer progression. Conversely, some cells actively repress apoptosis to become polyploid as part of normal development or regeneration. Thus, although apoptosis prevents polyploidy, the polyploid state can actively repress apoptosis. In this review, we discuss progress in understanding the antagonistic relationship between apoptosis and polyploidy in development and cancer. Despite recent advances, a key conclusion is that much remains unknown about the mechanisms that link apoptosis to polyploid cell cycles. We suggest that drawing parallels between the regulation of apoptosis in development and cancer could help to fill this knowledge gap and lead to more effective therapies.
One of the important functions of regulated cell death is to prevent cells from inappropriately acquiring extra copies of their genome, a state known as polyploidy. Apoptosis is the primary cell death mechanism that prevents polyploidy, and defects in this apoptotic response can result in polyploid cells whose subsequent error-prone chromosome segregation are a major contributor to genome instability and cancer progression. Conversely, some cells actively repress apoptosis to become polyploid as part of normal development or regeneration. Thus, although apoptosis prevents polyploidy, the polyploid state can actively repress apoptosis. In this review, we discuss progress in understanding the antagonistic relationship between apoptosis and polyploidy in development and cancer. Despite recent advances, a key conclusion is that much remains unknown about the mechanisms that link apoptosis to polyploid cell cycles. We suggest that drawing parallels between the regulation of apoptosis in development and cancer could help to fill this knowledge gap and lead to more effective therapies.One of the important functions of regulated cell death is to prevent cells from inappropriately acquiring extra copies of their genome, a state known as polyploidy. Apoptosis is the primary cell death mechanism that prevents polyploidy, and defects in this apoptotic response can result in polyploid cells whose subsequent error-prone chromosome segregation are a major contributor to genome instability and cancer progression. Conversely, some cells actively repress apoptosis to become polyploid as part of normal development or regeneration. Thus, although apoptosis prevents polyploidy, the polyploid state can actively repress apoptosis. In this review, we discuss progress in understanding the antagonistic relationship between apoptosis and polyploidy in development and cancer. Despite recent advances, a key conclusion is that much remains unknown about the mechanisms that link apoptosis to polyploid cell cycles. We suggest that drawing parallels between the regulation of apoptosis in development and cancer could help to fill this knowledge gap and lead to more effective therapies.
Author Herriage, Hunter C.
Huang, Yi-Ting
Calvi, Brian R.
AuthorAffiliation 1: Department of Biology, Indiana University, Bloomington, IN 47405
AuthorAffiliation_xml – name: 1: Department of Biology, Indiana University, Bloomington, IN 47405
Author_xml – sequence: 1
  givenname: Hunter C.
  surname: Herriage
  fullname: Herriage, Hunter C.
– sequence: 2
  givenname: Yi-Ting
  surname: Huang
  fullname: Huang, Yi-Ting
– sequence: 3
  givenname: Brian R.
  surname: Calvi
  fullname: Calvi, Brian R.
  email: bcalvi@indiana.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37331841$$D View this record in MEDLINE/PubMed
BookMark eNqFUctu1DAUtVAr-oA_QChLNknt2LETFiBU0RapEpsisbP8uOl4lNjB9gyav8fTaRGwKCtbOq-rc87QkQ8eEHpDcEMw4RfrJsFsrG5a3NIGdw3Gwwt0SvDAa8opO9r_e1YPXUtO0FlKa4wxG1r-Ep1QQSnpGTlF3-9WUCmf1X3wLmVnqgiTyi74tHJLpSH_BPCVWsKSQ3KpcG21hGm3TMHZXeV8ZWELU1hm8PkBNcobiK_Q8aimBK8f33P07erz3eVNffv1-svlp9vasJ7lehw1xZpr1g7AsWiZIUxQwhVulRWYGGH10FPeazF2vCDARKcp05QqTRSm5-jjwXfZ6BmsKVdENcklulnFnQzKyb8R71byPmwl2adR0RWHd48OMfzYQMpydsnANCkPYZNk27eCc057Uqhv_wz7nfLUZyG8PxBMDClFGKVx-aHOku2mEir348m1PIwn9-NJ3MkyXhGzf8RP_v-RfTjIoNS8dRBlMg7KBtZFMFna4J43-AWv8Lc6
CitedBy_id crossref_primary_10_1016_j_jep_2024_118811
crossref_primary_10_1093_genetics_iyad208
crossref_primary_10_3389_fcell_2024_1410637
crossref_primary_10_1016_j_ijbiomac_2024_131706
crossref_primary_10_3390_genes15010096
crossref_primary_10_3390_ijms25084185
crossref_primary_10_3892_or_2024_8760
crossref_primary_10_1016_j_canlet_2025_217447
crossref_primary_10_1093_genetics_iyae009
Cites_doi 10.1016/j.semcancer.2020.11.016
10.1038/sj.onc.1207528
10.1002/ijc.26309
10.1186/s13287-020-01848-8
10.1016/j.canlet.2007.07.003
10.1038/s41586-020-03133-3
10.1038/nrc2272
10.1101/gad.1447006
10.1242/dev.122.4.1051
10.1186/1475-2867-1-1
10.1101/gad.349727.122
10.3390/ijms23169409
10.1016/S0960-9822(98)70089-2
10.1101/gad.10.19.2514
10.1016/j.jhep.2021.06.030
10.1038/s41419-021-04321-3
10.1371/journal.pone.0151251
10.1016/j.tig.2022.04.005
10.1016/j.cell.2018.07.042
10.1073/pnas.1304889110
10.1101/gad.289728.116
10.1016/j.devcel.2016.05.004
10.1016/S0960-9822(02)00845-X
10.15252/embj.2021108389
10.1038/sj.onc.1207572
10.1016/j.semcancer.2021.09.011
10.1038/ncb2595
10.1016/j.cellbi.2005.10.003
10.1016/j.devcel.2014.12.015
10.1242/jcs.064519
10.1242/dev.109850
10.1158/1541-7786.MCR-10-0570
10.1002/jcb.10411
10.1006/cbir.2000.0557
10.3389/fpls.2022.869423
10.1016/j.devcel.2019.03.015
10.1152/physiolgenomics.00028.2012
10.1101/cshperspect.a040881
10.1016/j.ccr.2008.07.002
10.1038/nrc.2015.2
10.4161/cc.8.10.8325
10.1093/annonc/mdw612
10.1038/sj.emboj.7601127
10.1038/s41588-018-0165-1
10.1016/j.cell.2010.01.031
10.1073/pnas.1306908110
10.1016/S0092-8674(00)80528-0
10.1242/dev.156034
10.1534/genetics.115.186627
10.1146/annurev-cellbio-092910-154234
10.7554/eLife.38327
10.1007/978-3-030-23629-8_6
10.1091/mbc.E16-03-0159
10.1016/j.cell.2010.11.055
10.1242/dev.00933
10.7554/eLife.15204
10.1038/s41586-022-04578-4
10.1242/dev.016295
10.1038/ng.2760
10.1091/mbc.12.5.1315
10.1016/j.tig.2018.10.005
10.1038/ncomms1825
10.1016/j.bbrc.2012.11.075
10.1083/jcb.200610099
10.1016/j.semcancer.2021.10.006
10.1242/dev.199401
10.1016/j.devcel.2017.08.024
10.1016/j.cub.2019.09.041
10.1016/j.cellbi.2005.10.008
10.3324/haematol.2016.149914
10.1016/j.cytogfr.2019.11.002
10.1016/j.devcel.2018.01.021
10.1158/2159-8290.CD-13-0285
10.1091/mbc.e16-03-0139
10.1111/j.1365-2362.1993.tb00723.x
10.1038/nature10802
10.1080/09537104.2019.1667497
10.1073/pnas.97.13.7301
10.1371/journal.pone.0097434
10.1083/jcb.201502016
10.1007/BF00283238
10.1155/2015/146282
10.1371/journal.pgen.1004290
10.1016/j.cell.2014.06.029
10.1101/gad.1954410
10.1038/cdd.2010.145
10.1016/j.devcel.2021.05.017
10.1016/j.mod.2018.05.007
10.1083/jcb.200703206
10.1055/s-0040-1719175
10.1038/nature08136
10.1002/ijc.28319
10.1101/gr.114611.110
10.1242/dev.124.18.3555
10.1073/pnas.1103584108
10.1016/j.semcdb.2015.02.001
10.7554/eLife.54385
10.1007/s00412-008-0163-7
10.1038/s41576-019-0171-x
10.1091/mbc.E15-01-0003
10.1016/j.tcb.2020.06.006
10.1016/j.cancergen.2012.12.001
10.1016/j.cub.2007.01.049
10.1242/dev.080531
10.1016/j.cub.2013.09.029
10.1038/srep08907
10.1038/bjc.1972.33
10.1101/cshperspect.a012948
10.1101/gad.469108
10.4161/cc.8.19.9729
10.1038/nature04217
10.1038/onc.2008.77
10.1016/j.molonc.2011.07.007
10.1016/j.ccr.2012.03.044
10.1242/dev.098871
10.1101/gad.276287.115
10.1038/s41586-022-05082-5
10.1006/cbir.2000.0558
10.1111/j.1365-2583.2007.00785.x
10.1016/j.cell.2010.12.025
10.1158/0008-5472.CAN-08-3364
10.1038/nrm2718
10.1101/gad.1710208
10.1038/s41418-017-0012-4
10.1002/bies.201000089
10.1242/jcs.039719
10.1016/j.cellbi.2008.04.021
10.1101/gad.245811.114
10.1534/genetics.109.102327
10.1073/pnas.2020838118
10.1242/jcs.025742
10.1016/S0143-4004(03)00215-7
10.1371/journal.pone.0203991
10.1038/381713a0
10.1007/s10577-021-09664-3
10.1101/gad.1952710
10.1371/journal.pgen.1008253
10.1038/ncb2585
10.1016/j.cell.2022.12.036
10.1101/gad.1718108
10.1038/onc.2013.96
10.1016/S0092-8674(00)80626-1
10.1371/journal.pgen.1004581
10.1073/pnas.1415287111
10.1016/j.stem.2019.11.014
10.1242/dev.173005
10.1073/pnas.0510528103
ContentType Journal Article
Copyright 2023 Elsevier Ltd
Copyright © 2023 Elsevier Ltd. All rights reserved.
Copyright_xml – notice: 2023 Elsevier Ltd
– notice: Copyright © 2023 Elsevier Ltd. All rights reserved.
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOI 10.1016/j.semcdb.2023.05.009
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList

MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1096-3634
EndPage 43
ExternalDocumentID PMC10724375
37331841
10_1016_j_semcdb_2023_05_009
S108495212300126X
Genre Journal Article
Review
GrantInformation_xml – fundername: NIGMS NIH HHS
  grantid: R01 GM113107
GroupedDBID ---
--K
--M
-DZ
.~1
0R~
123
1B1
1RT
1~.
4.4
457
4G.
5VS
71M
8P~
AACTN
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAXUO
ABFRF
ABGSF
ABJNI
ABLJU
ABMAC
ABUDA
ABYKQ
ACDAQ
ACGFO
ACGFS
ACRLP
ADBBV
ADEZE
ADUVX
AEBSH
AEFWE
AEHWI
AEKER
AENEX
AFKWA
AFTJW
AFXIZ
AGHFR
AGUBO
AGYEJ
AIEXJ
AIKHN
AITUG
AJOXV
AKRWK
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
AXJTR
BKOJK
BLXMC
CS3
DM4
DOVZS
DU5
EBS
EFBJH
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FIRID
FNPLU
FYGXN
G-Q
GBLVA
HVGLF
IHE
J1W
KOM
LG5
M41
MO0
N9A
O-L
O9-
OAUVE
OZT
P-8
P-9
P2P
PC.
Q38
RIG
ROL
RPZ
SCC
SDF
SDG
SDP
SES
SEW
SPCBC
SSU
SSZ
T5K
~G-
1~5
53G
7-5
AAQXK
AATTM
AAXKI
AAYWO
AAYXX
ABWVN
ABXDB
ACRPL
ACVFH
ADCNI
ADFGL
ADMUD
ADNMO
ADVLN
AEIPS
AEUPX
AFFNX
AFJKZ
AFPUW
AGCQF
AGQPQ
AGRDE
AGRNS
AIGII
AIIUN
AKBMS
AKYEP
ANKPU
APXCP
ASPBG
AVWKF
AZFZN
BNPGV
CAG
CITATION
COF
EJD
FGOYB
HX~
HZ~
R2-
SSH
UDS
XPP
ZMT
CGR
CUY
CVF
ECM
EFKBS
EIF
NPM
7X8
5PM
ID FETCH-LOGICAL-c484t-ffb30b6b429e60724c147316a02ad701c7db98368b7f56731e475b34b33ab1a03
IEDL.DBID .~1
ISSN 1084-9521
1096-3634
IngestDate Thu Aug 21 18:33:55 EDT 2025
Fri Jul 11 04:55:50 EDT 2025
Mon Jul 21 05:48:21 EDT 2025
Tue Jul 01 01:09:02 EDT 2025
Thu Apr 24 23:05:07 EDT 2025
Sat Apr 20 15:59:15 EDT 2024
IsPeerReviewed true
IsScholarly true
Keywords PGCC
Polyploidy
devEC
WGD
iEC
Tetraploid
Regulated cell death
Endoreplication
Aneuploidy
CNV
CDK
Apoptosis
Language English
License Copyright © 2023 Elsevier Ltd. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c484t-ffb30b6b429e60724c147316a02ad701c7db98368b7f56731e475b34b33ab1a03
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
PMID 37331841
PQID 2827666381
PQPubID 23479
PageCount 9
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_10724375
proquest_miscellaneous_2827666381
pubmed_primary_37331841
crossref_citationtrail_10_1016_j_semcdb_2023_05_009
crossref_primary_10_1016_j_semcdb_2023_05_009
elsevier_sciencedirect_doi_10_1016_j_semcdb_2023_05_009
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2024-03-15
PublicationDateYYYYMMDD 2024-03-15
PublicationDate_xml – month: 03
  year: 2024
  text: 2024-03-15
  day: 15
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Seminars in cell & developmental biology
PublicationTitleAlternate Semin Cell Dev Biol
PublicationYear 2024
Publisher Elsevier Ltd
Publisher_xml – name: Elsevier Ltd
References Margolis, Lohez, Andreassen (bib82) 2003; 88
Illidge, Cragg, Fringes, Olive, Erenpreisa (bib141) 2000; 24
Duelli, Lazebnik (bib110) 2007; 7
Puig, Guilly, Bouchot, Droin, Cathelin, Bouyer, Favier, Ghiringhelli, Kroemer, Solary, Martin, Chauffert (bib116) 2008; 32
Mc Gee (bib85) 2015; 2015
Kirillova, Han, Liu, Kuhn (bib9) 2021; 148
Luff, Kao, Papoutsakis (bib58) 2018; 13
Ianzini, Kosmacek, Nelson, Napoli, Erenpreisa, Kalejs, Mackey (bib148) 2009; 69
Crockford, Zalmas, Gronroos, Dewhurst, McGranahan, Cuomo, Encheva, Snijders, Begum, Purewal, Cerveira, Patel, Renshaw, Swanton (bib129) 2017; 28
Nano, Gemble, Simon, Pennetier, Fraisier, Marthiens, Basto (bib137) 2019; 29
Wang, Yang, Gong, Chang, Portilla, Chatterjee, Irianto, Bao, Huang, Deng (bib112) 2021; 56
Galluzzi, Vitale, Aaronson, Abrams, Adam, Agostinis, Alnemri, Altucci, Amelio, Andrews, Annicchiarico-Petruzzelli, Antonov, Arama, Baehrecke, Barlev, Bazan, Bernassola, Bertrand, Bianchi, Blagosklonny, Blomgren, Borner, Boya, Brenner, Campanella, Candi, Carmona-Gutierrez, Cecconi, Chan, Chandel, Cheng, Chipuk, Cidlowski, Ciechanover, Cohen, Conrad, Cubillos-Ruiz, Czabotar, D'Angiolella, Dawson, Dawson, De Laurenzi, De Maria, Debatin, DeBerardinis, Deshmukh, Di Daniele, Di Virgilio, Dixit, Dixon, Duckett, Dynlacht, El-Deiry, Elrod, Fimia, Fulda, Garcia-Saez, Garg, Garrido, Gavathiotis, Golstein, Gottlieb, Green, Greene, Gronemeyer, Gross, Hajnoczky, Hardwick, Harris, Hengartner, Hetz, Ichijo, Jaattela, Joseph, Jost, Juin, Kaiser, Karin, Kaufmann, Kepp, Kimchi, Kitsis, Klionsky, Knight, Kumar, Lee, Lemasters, Levine, Linkermann, Lipton, Lockshin, Lopez-Otin, Lowe, Luedde, Lugli, MacFarlane, Madeo, Malewicz, Malorni, Manic, Marine, Martin, Martinou, Medema, Mehlen, Meier, Melino, Miao, Molkentin, Moll, Munoz-Pinedo, Nagata, Nunez, Oberst, Oren, Overholtzer, Pagano, Panaretakis, Pasparakis, Penninger, Pereira, Pervaiz, Peter, Piacentini, Pinton, Prehn, Puthalakath, Rabinovich, Rehm, Rizzuto, Rodrigues, Rubinsztein, Rudel, Ryan, Sayan, Scorrano, Shao, Shi, Silke, Simon, Sistigu, Stockwell, Strasser, Szabadkai, Tait, Tang, Tavernarakis, Thorburn, Tsujimoto, Turk, Vanden Berghe, Vandenabeele, Vander Heiden, Villunger, Virgin, Vousden, Vucic, Wagner, Walczak, Wallach, Wang, Wells, Wood, Yuan, Zakeri, Zhivotovsky, Zitvogel, Melino, Kroemer (bib2) 2018; 25
Castedo, Perfettini, Roumier, Valent, Raslova, Yakushijin, Horne, Feunteun, Lenoir, Medema, Vainchenker, Kroemer (bib92) 2004; 23
Fava, Schuler, Sladky, Haschka, Soratroi, Eiterer, Demetz, Weiss, Geley, Nigg, Villunger (bib93) 2017; 31
Waldman, Lengauer, Kinzler, Vogelstein (bib145) 1996; 381
Trakala, Rodriguez-Acebes, Maroto, Symonds, Santamaria, Ortega, Barbacid, Mendez, Malumbres (bib55) 2015; 32
Bretscher, Fox (bib49) 2016; 37
Roberts, Allison, Donehower, Rowinsky (bib123) 1990; 50
Stephens, Greenman, Fu, Yang, Bignell, Mudie, Pleasance, Lau, Beare, Stebbings, McLaren, Lin, McBride, Varela, Nik-Zainal, Leroy, Jia, Menzies, Butler, Teague, Quail, Burton, Swerdlow, Carter, Morsberger, Iacobuzio-Donahue, Follows, Green, Flanagan, Stratton, Futreal, Campbell (bib105) 2011; 144
Duelli, Padilla-Nash, Berman, Murphy, Ried, Lazebnik (bib111) 2007; 17
Pienta, Hammarlund, Austin, Axelrod, Brown, Amend (bib37) 2022; 81
Gascoigne, Taylor (bib88) 2008; 14
Fox, Soltis, Soltis, Ashman, Van de Peer (bib7) 2020; 30
Bailey, Kobielski, Park, Losick (bib32) 2021; 13
Liu, Erenpreisa, Sikora (bib38) 2022; 81
Vainchenker, Raslova (bib54) 2020; 31
Ullah, Naz, Akram, Ullah, Tariq, Mithani, Faisal (bib22) 2020; 11
Crasta, Ganem, Dagher, Lantermann, Ivanova, Pan, Nezi, Protopopov, Chowdhury, Pellman (bib104) 2012; 482
Boveri (bib34) 2008; 121
Roos, Thomas, Kaina (bib3) 2016; 16
Hassel, Zhang, Dixon, Calvi (bib75) 2014; 141
Nandakumar, Grushko, Buttitta (bib81) 2020; 9
Ovrebo, Edgar (bib15) 2018; 145
Castedo, Coquelle, Vivet, Vitale, Kauffmann, Dessen, Pequignot, Casares, Valent, Mouhamad, Schmitt, Modjtahedi, Vainchenker, Zitvogel, Lazar, Garrido, Kroemer (bib91) 2006; 25
Davoli, Denchi, de Lange (bib114) 2010; 141
Losick, Jun, Spradling (bib29) 2016; 11
Adachi, Minamisawa, Okushima, Inagaki, Yoshiyama, Kondou, Kaminuma, Kawashima, Toyoda, Matsui, Kurihara, Matsunaga, Umeda (bib155) 2011; 108
Cao, Wang, Jackman, Cox, Trembley, Balowski, Cox, De Simone, Dickson, Di Talia, Small, Kiehart, Bursac, Poss (bib27) 2017; 42
Zielke, Edgar, DePamphilis (bib12) 2013; 5
Stormo, Fox (bib140) 2016; 5
Narbonne Reveau, Senger, Pal, Herr, Richardson, Asano, Deak, Lilly (bib19) 2008; 135
Holland, Cleveland (bib35) 2009; 10
Almeida Machado Costa, Wang, Ellsworth, Deng (bib109) 2022; 81
Sagulenko, Savelyeva, Ehemann, Sagulenko, Hofmann, Arnold, Claas, Scherneck, Schwab (bib117) 2007; 257
Hayashi, Cdc2 (bib78) 1996; 122
Erenpreisa, Cragg, Fringes, Sharakhov, Illidge (bib151) 2000; 24
Chen, Ouseph, Li, Pecot, Chokshi, Kent, Bae, Byrne, Duran, Comstock, Trikha, Mair, Senapati, Martin, Gandhi, Wilson, Liu, Huang, Thompson, Raman, Singh, Leone, Machiraju, Huang, Mo, Fernandez, Kalaszczynska, Wolgemuth, Sicinski, Huang, Jin, Leone (bib24) 2012; 14
Wilkinson, Duncan (bib69) 2021; 41
Calvi (bib6) 2013; 110
Chen, Stout, Dharmaiah, Yde, Calvi, Walczak (bib102) 2016; 27
Rotelli, Policastro, Bolling, Killion, Weinberg, Dixon, Zentner, Walczak, Lilly, Calvi, Cyclin (bib16) 2019; 15
de Renty, DePamphilis, Ullah (bib53) 2014; 9
Yarosh, Spradling (bib63) 2014; 28
Knouse, Lopez, Bachofner, Amon (bib73) 2018; 175
Knouse, Wu, Whittaker, Amon (bib72) 2014; 111
Vitale, Galluzzi, Senovilla, Criollo, Jemaa, Castedo, Kroemer (bib84) 2011; 18
Horii, Yamamoto, Morita, Kimura, Nagao, Hatada (bib124) 2015; 5
Davoli, de Lange (bib103) 2012; 21
Yang, Portilla, Mihailovic, Huang, Deng (bib113) 2019; 49
Dikovskaya, Schiffmann, Newton, Oakley, Kroboth, Sansom, Jamieson, Meniel, Clarke, Nathke (bib133) 2007; 176
Gascoigne, Taylor (bib89) 2009; 122
Manic, Galluzzi, Vitale (bib135) 2022; 38
Schoenfelder, Fox (bib26) 2015; 209
Belyaeva, Andreyeva, Belyakin, Volkova, Zhimulev (bib62) 2008; 117
Deng, Gutierrez, Stoll, Motino, Martins, Nunez, Bravo-San Pedro, Humeau, Bordenave, Pan, Fohrer-Ting, Souquere, Pierron, Hetz, Villalobos, Kroemer, Senovilla (bib94) 2021; 12
Aylon, Michael, Shmueli, Yabuta, Nojima, Oren (bib131) 2006; 20
Sladky, Akbari, Tapias-Gomez, Evans, Drown, Strong, LoMastro, Larman, Holland (bib95) 2022; 36
Vitale, Manic, Castedo, Kroemer (bib87) 2017; 4
Ben-David, Amon (bib99) 2020; 21
Gonzalez-Rosa, Sharpe, Field, Soonpaa, Field, Burns, Burns (bib36) 2018; 44
Yu, Marion, Austria, Yeh, Schonthal, Dubeau (bib118) 2012; 130
Matsumoto, Wakefield, Tarlow, Grompe (bib71) 2020; 26
Peterson, Fox (bib11) 2021; 29
Zhang, Mehrotra, Ng, Calvi (bib46) 2014; 10
Pandit, Westendorp, Nantasanti, van Liere, Tooten, Cornelissen, Toussaint, Lamers, de Bruin (bib25) 2012; 14
Vidwans, DiGregorio, Shermoen, Foat, Iwasa, Yakubovich, O'Farrell (bib76) 2002; 12
Kerr, Wyllie, Currie (bib1) 1972; 26
Ganem, Godinho, Pellman (bib101) 2009; 460
Schoenfelder, Montague, Paramore, Lennox, Mahowald, Fox (bib48) 2014; 141
Nordman, Li, Eng, Macalpine, Orr-Weaver (bib66) 2011; 21
Sigrist, Lehner (bib13) 1997; 90
Hannibal, Chuong, Rivera-Mulia, Gilbert, Valouev, Baker (bib68) 2014; 10
Qi, Calvi (bib79) 2016; 27
Potapova, Gorbsky (bib128) 2017; 6
Zhang, Mercado-Uribe, Liu (bib146) 2014; 134
Zhu, Lee, Johnson, Wichterman, Huang, DePamphilis (bib120) 2011; 9
Dewhurst, McGranahan, Burrell, Rowan, Gronroos, Endesfelder, Joshi, Mouradov, Gibbs, Ward, Hawkins, Szallasi, Sieber, Swanton (bib107) 2014; 4
Maqbool, Mehrotra, Kolpakas, Durden, Zhang, Zhong, Calvi (bib23) 2010; 123
Gemble, Wardenaar, Keuper, Srivastava, Nano, Mace, Tijhuis, Bernhard, Spierings, Simon, Goundiam, Hochegger, Piel, Foijer, Storchova, Basto (bib136) 2022; 604
Ollmann, Young, Di Como, Karim, Belvin, Robertson, Whittaker, Demsky, Fisher, Buchman, Duyk, Friedman, Prives, Kopczynski (bib40) 2000; 101
Rajaraman, Rajaraman, Rajaraman, Guernsey (bib149) 2005; 29
Liu, Lehmann (bib60) 2008; 17
Hua, Orr-Weaver (bib65) 2017; 207
Fujiwara, Bandi, Nitta, Ivanova, Bronson, Pellman (bib98) 2005; 437
Sadaie, Dillon, Narita, Young, Cairney, Godwin, Torrance, Bennett, Keith, Narita (bib119) 2015; 26
Lachaud, Slean, Marchesi, Lock, Odell, Castor, Toth, Rouse (bib31) 2016; 30
Losick, Fox, Spradling (bib28) 2013; 23
Andreassen, Lohez, Lacroix, Margolis (bib83) 2001; 12
Klusza, Deng (bib14) 2011; 33
Erenpreisa, Kalejs, Ianzini, Kosmacek, Mackey, Emzinsh, Cragg, Ivanov, Illidge (bib150) 2005; 29
Lilly, Spradling (bib20) 1996; 10
van der Loo, Hong, Hancock, Martin, Erusalimsky (bib122) 1993; 23
Apostolidis, Lindsey, Miller, Papoutsakis (bib57) 2012; 44
Aylon, Ofir-Rosenfeld, Yabuta, Lapi, Nojima, Lu, Oren (bib130) 2010; 24
Bohm, Sandritter (bib143) 1975; 60
Zielke, Querings, Rottig, Lehner, Sprenger (bib18) 2008; 22
Godinho, Pellman (bib100) 1650; 369
Ganem, Cornils, Chiu, O'Rourke, Arnaud, Yimlamai, Thery, Camargo, Pellman (bib90) 2014; 158
Tossi, Martinez Tosar, Laino, Iannicelli, Regalado, Escandon, Baroli, Causin, Pitta-Alvarez (bib154) 2022; 13
Sher, Von Stetina, Bell, Matsuura, Ravid, Orr-Weaver (bib67) 2013; 110
Fox, Duronio (bib5) 2013; 140
Yin, Thummel, Bashirullah (bib59) 2007; 178
Pienta, Hammarlund, Brown, Amend, Axelrod (bib115) 2021; 118
Vendramin, Litchfield, Swanton (bib138) 2021; 40
Zack, Schumacher, Carter, Cherniack, Saksena, Tabak, Lawrence, Zhsng, Wala, Mermel, Sougnez, Gabriel, Hernandez, Shen, Laird, Getz, Meyerson, Beroukhim (bib97) 2013; 45
Endow, Gall (bib64) 1975; 50
Valent, Penault-Llorca, Cayre, Kroemer (bib121) 2013; 206
Follette, Duronio, O'Farrell (bib17) 1998; 8
Castedo, Perfettini, Roumier, Andreau, Medema, Kroemer (bib86) 2004; 23
Bracey, Williams, Paraskeva (bib144) 1997; 3
Cohen, Allen, Sawyer, Fox (bib30) 2018; 7
Fox, Gall, Spradling (bib47) 2010; 24
Zeng, Hills, Ozono, Diffley (bib127) 2023; 186
Ingaramo, Sanchez, Dekanty (bib39) 2018; 154
Soloveva, Linzer (bib52) 2004; 25
Davoli, de Lange (bib108) 2011; 27
Finkin, Aylon, Anzi, Oren, Shaulian (bib132) 2008; 27
Naoe, Chiyoda, Ishizawa, Masuda, Saya, Kuninaka (bib21) 2013; 430
Jin, Martinek, Joo, Wortman, Mirkovic,
Nano (10.1016/j.semcdb.2023.05.009_bib137) 2019; 29
Pandit (10.1016/j.semcdb.2023.05.009_bib25) 2012; 14
Zhang (10.1016/j.semcdb.2023.05.009_bib152) 2014; 33
Zielke (10.1016/j.semcdb.2023.05.009_bib12) 2013; 5
Schoenfelder (10.1016/j.semcdb.2023.05.009_bib26) 2015; 209
Ben-David (10.1016/j.semcdb.2023.05.009_bib99) 2020; 21
Potapova (10.1016/j.semcdb.2023.05.009_bib128) 2017; 6
Roy (10.1016/j.semcdb.2023.05.009_bib56) 2016; 101
Vidwans (10.1016/j.semcdb.2023.05.009_bib76) 2002; 12
Erenpreisa (10.1016/j.semcdb.2023.05.009_bib151) 2000; 24
Luff (10.1016/j.semcdb.2023.05.009_bib58) 2018; 13
Yang (10.1016/j.semcdb.2023.05.009_bib113) 2019; 49
Gonzalez-Rosa (10.1016/j.semcdb.2023.05.009_bib36) 2018; 44
Lilly (10.1016/j.semcdb.2023.05.009_bib20) 1996; 10
Sladky (10.1016/j.semcdb.2023.05.009_bib95) 2022; 36
Aylon (10.1016/j.semcdb.2023.05.009_bib131) 2006; 20
Martin (10.1016/j.semcdb.2023.05.009_bib61) 2004; 131
Stephens (10.1016/j.semcdb.2023.05.009_bib105) 2011; 144
Calvi (10.1016/j.semcdb.2023.05.009_bib6) 2013; 110
Chen (10.1016/j.semcdb.2023.05.009_bib24) 2012; 14
Hayashi (10.1016/j.semcdb.2023.05.009_bib78) 1996; 122
Stormo (10.1016/j.semcdb.2023.05.009_bib140) 2016; 5
Zielke (10.1016/j.semcdb.2023.05.009_bib18) 2008; 22
Fox (10.1016/j.semcdb.2023.05.009_bib47) 2010; 24
Yarosh (10.1016/j.semcdb.2023.05.009_bib63) 2014; 28
Matsumoto (10.1016/j.semcdb.2023.05.009_bib10) 2022; 23
Zack (10.1016/j.semcdb.2023.05.009_bib97) 2013; 45
Follette (10.1016/j.semcdb.2023.05.009_bib17) 1998; 8
Erenpreisa (10.1016/j.semcdb.2023.05.009_bib142) 2001; 1
Zhang (10.1016/j.semcdb.2023.05.009_bib146) 2014; 134
Levan (10.1016/j.semcdb.2023.05.009_bib33) 1953; 14
Schoenfelder (10.1016/j.semcdb.2023.05.009_bib48) 2014; 141
Maqbool (10.1016/j.semcdb.2023.05.009_bib23) 2010; 123
Trakala (10.1016/j.semcdb.2023.05.009_bib55) 2015; 32
Liu (10.1016/j.semcdb.2023.05.009_bib38) 2022; 81
Davoli (10.1016/j.semcdb.2023.05.009_bib108) 2011; 27
Losick (10.1016/j.semcdb.2023.05.009_bib29) 2016; 11
Baslan (10.1016/j.semcdb.2023.05.009_bib126) 2022; 608
Sladky (10.1016/j.semcdb.2023.05.009_bib70) 2021; 75
Tao (10.1016/j.semcdb.2023.05.009_bib134) 2009; 8
Peterson (10.1016/j.semcdb.2023.05.009_bib11) 2021; 29
Zheng (10.1016/j.semcdb.2023.05.009_bib153) 2012; 3
Dikovskaya (10.1016/j.semcdb.2023.05.009_bib133) 2007; 176
Dewhurst (10.1016/j.semcdb.2023.05.009_bib107) 2014; 4
Kirillova (10.1016/j.semcdb.2023.05.009_bib9) 2021; 148
Yu (10.1016/j.semcdb.2023.05.009_bib118) 2012; 130
Naoe (10.1016/j.semcdb.2023.05.009_bib21) 2013; 430
Ullah (10.1016/j.semcdb.2023.05.009_bib51) 2008; 22
Bailey (10.1016/j.semcdb.2023.05.009_bib32) 2021; 13
de Renty (10.1016/j.semcdb.2023.05.009_bib53) 2014; 9
van der Loo (10.1016/j.semcdb.2023.05.009_bib122) 1993; 23
Roos (10.1016/j.semcdb.2023.05.009_bib3) 2016; 16
Nandakumar (10.1016/j.semcdb.2023.05.009_bib81) 2020; 9
Margolis (10.1016/j.semcdb.2023.05.009_bib82) 2003; 88
Fox (10.1016/j.semcdb.2023.05.009_bib5) 2013; 140
Aylon (10.1016/j.semcdb.2023.05.009_bib125) 2011; 5
Galluzzi (10.1016/j.semcdb.2023.05.009_bib2) 2018; 25
Yin (10.1016/j.semcdb.2023.05.009_bib59) 2007; 178
Illidge (10.1016/j.semcdb.2023.05.009_bib141) 2000; 24
Gascoigne (10.1016/j.semcdb.2023.05.009_bib89) 2009; 122
Castedo (10.1016/j.semcdb.2023.05.009_bib91) 2006; 25
Ganem (10.1016/j.semcdb.2023.05.009_bib101) 2009; 460
Chen (10.1016/j.semcdb.2023.05.009_bib102) 2016; 27
Vendramin (10.1016/j.semcdb.2023.05.009_bib138) 2021; 40
Arya (10.1016/j.semcdb.2023.05.009_bib4) 2015; 39
Cohen (10.1016/j.semcdb.2023.05.009_bib30) 2018; 7
Puig (10.1016/j.semcdb.2023.05.009_bib116) 2008; 32
Duelli (10.1016/j.semcdb.2023.05.009_bib110) 2007; 7
Horii (10.1016/j.semcdb.2023.05.009_bib124) 2015; 5
Bretscher (10.1016/j.semcdb.2023.05.009_bib49) 2016; 37
Wilkinson (10.1016/j.semcdb.2023.05.009_bib69) 2021; 41
Waldman (10.1016/j.semcdb.2023.05.009_bib145) 1996; 381
Liu (10.1016/j.semcdb.2023.05.009_bib60) 2008; 17
Sher (10.1016/j.semcdb.2023.05.009_bib67) 2013; 110
Godinho (10.1016/j.semcdb.2023.05.009_bib100) 1650; 369
Rajaraman (10.1016/j.semcdb.2023.05.009_bib149) 2005; 29
Bharadwaj (10.1016/j.semcdb.2023.05.009_bib147) 2020; 52
Castedo (10.1016/j.semcdb.2023.05.009_bib86) 2004; 23
Roberts (10.1016/j.semcdb.2023.05.009_bib123) 1990; 50
Gemble (10.1016/j.semcdb.2023.05.009_bib136) 2022; 604
Pienta (10.1016/j.semcdb.2023.05.009_bib37) 2022; 81
Bohm (10.1016/j.semcdb.2023.05.009_bib143) 1975; 60
Kerr (10.1016/j.semcdb.2023.05.009_bib1) 1972; 26
Boveri (10.1016/j.semcdb.2023.05.009_bib34) 2008; 121
Gjelsvik (10.1016/j.semcdb.2023.05.009_bib74) 2019; 35
Meyerson (10.1016/j.semcdb.2023.05.009_bib106) 2011; 144
Ullah (10.1016/j.semcdb.2023.05.009_bib8) 2009; 8
Ianzini (10.1016/j.semcdb.2023.05.009_bib148) 2009; 69
Belyaeva (10.1016/j.semcdb.2023.05.009_bib62) 2008; 117
Aylon (10.1016/j.semcdb.2023.05.009_bib130) 2010; 24
Quinton (10.1016/j.semcdb.2023.05.009_bib139) 2021; 590
Rotelli (10.1016/j.semcdb.2023.05.009_bib16) 2019; 15
Deng (10.1016/j.semcdb.2023.05.009_bib94) 2021; 12
Vitale (10.1016/j.semcdb.2023.05.009_bib84) 2011; 18
Finkin (10.1016/j.semcdb.2023.05.009_bib132) 2008; 27
Bracey (10.1016/j.semcdb.2023.05.009_bib144) 1997; 3
Zhu (10.1016/j.semcdb.2023.05.009_bib120) 2011; 9
Zhou (10.1016/j.semcdb.2023.05.009_bib42) 2019; 1167
Zeng (10.1016/j.semcdb.2023.05.009_bib127) 2023; 186
Ollmann (10.1016/j.semcdb.2023.05.009_bib40) 2000; 101
Andreassen (10.1016/j.semcdb.2023.05.009_bib83) 2001; 12
Almeida Machado Costa (10.1016/j.semcdb.2023.05.009_bib109) 2022; 81
Bielski (10.1016/j.semcdb.2023.05.009_bib96) 2018; 50
Davoli (10.1016/j.semcdb.2023.05.009_bib103) 2012; 21
Fava (10.1016/j.semcdb.2023.05.009_bib93) 2017; 31
Davoli (10.1016/j.semcdb.2023.05.009_bib114) 2010; 141
Narbonne Reveau (10.1016/j.semcdb.2023.05.009_bib19) 2008; 135
Weigmann (10.1016/j.semcdb.2023.05.009_bib77) 1997; 124
Mehrotra (10.1016/j.semcdb.2023.05.009_bib45) 2008; 22
Cao (10.1016/j.semcdb.2023.05.009_bib27) 2017; 42
Vainchenker (10.1016/j.semcdb.2023.05.009_bib54) 2020; 31
Jin (10.1016/j.semcdb.2023.05.009_bib41) 2000; 97
Tossi (10.1016/j.semcdb.2023.05.009_bib154) 2022; 13
Sigrist (10.1016/j.semcdb.2023.05.009_bib13) 1997; 90
Wichmann (10.1016/j.semcdb.2023.05.009_bib43) 2006; 103
Crockford (10.1016/j.semcdb.2023.05.009_bib129) 2017; 28
Mc Gee (10.1016/j.semcdb.2023.05.009_bib85) 2015; 2015
Fox (10.1016/j.semcdb.2023.05.009_bib7) 2020; 30
Klusza (10.1016/j.semcdb.2023.05.009_bib14) 2011; 33
Fujiwara (10.1016/j.semcdb.2023.05.009_bib98) 2005; 437
Vitale (10.1016/j.semcdb.2023.05.009_bib87) 2017; 4
Ovrebo (10.1016/j.semcdb.2023.05.009_bib15) 2018; 145
Ullah (10.1016/j.semcdb.2023.05.009_bib22) 2020; 11
Gascoigne (10.1016/j.semcdb.2023.05.009_bib88) 2008; 14
Soloveva (10.1016/j.semcdb.2023.05.009_bib52) 2004; 25
Knouse (10.1016/j.semcdb.2023.05.009_bib73) 2018; 175
Fei (10.1016/j.semcdb.2023.05.009_bib50) 2002; 62
Sadaie (10.1016/j.semcdb.2023.05.009_bib119) 2015; 26
Hannibal (10.1016/j.semcdb.2023.05.009_bib68) 2014; 10
Matsumoto (10.1016/j.semcdb.2023.05.009_bib71) 2020; 26
Wang (10.1016/j.semcdb.2023.05.009_bib112) 2021; 56
Sagulenko (10.1016/j.semcdb.2023.05.009_bib117) 2007; 257
Endow (10.1016/j.semcdb.2023.05.009_bib64) 1975; 50
Valent (10.1016/j.semcdb.2023.05.009_bib121) 2013; 206
Knouse (10.1016/j.semcdb.2023.05.009_bib72) 2014; 111
Nordman (10.1016/j.semcdb.2023.05.009_bib66) 2011; 21
Qi (10.1016/j.semcdb.2023.05.009_bib79) 2016; 27
Ganem (10.1016/j.semcdb.2023.05.009_bib90) 2014; 158
Adachi (10.1016/j.semcdb.2023.05.009_bib155) 2011; 108
Duelli (10.1016/j.semcdb.2023.05.009_bib111) 2007; 17
Lachaud (10.1016/j.semcdb.2023.05.009_bib31) 2016; 30
Losick (10.1016/j.semcdb.2023.05.009_bib28) 2013; 23
Apostolidis (10.1016/j.semcdb.2023.05.009_bib57) 2012; 44
Holland (10.1016/j.semcdb.2023.05.009_bib35) 2009; 10
Hua (10.1016/j.semcdb.2023.05.009_bib65) 2017; 207
Ingaramo (10.1016/j.semcdb.2023.05.009_bib39) 2018; 154
Hassel (10.1016/j.semcdb.2023.05.009_bib75) 2014; 141
Crasta (10.1016/j.semcdb.2023.05.009_bib104) 2012; 482
Erenpreisa (10.1016/j.semcdb.2023.05.009_bib150) 2005; 29
Grendler (10.1016/j.semcdb.2023.05.009_bib80) 2019; 146
Castedo (10.1016/j.semcdb.2023.05.009_bib92) 2004; 23
Zhang (10.1016/j.semcdb.2023.05.009_bib46) 2014; 10
Pienta (10.1016/j.semcdb.2023.05.009_bib115) 2021; 118
Manic (10.1016/j.semcdb.2023.05.009_bib135) 2022; 38
McNamee (10.1016/j.semcdb.2023.05.009_bib44) 2009; 182
References_xml – volume: 134
  start-page: 508
  year: 2014
  end-page: 518
  ident: bib146
  article-title: Tumor stroma and differentiated cancer cells can be originated directly from polyploid giant cancer cells induced by paclitaxel
  publication-title: Int. J. Cancer
– volume: 5
  start-page: 8907
  year: 2015
  ident: bib124
  article-title: p53 suppresses tetraploid development in mice
  publication-title: Sci. Rep.
– volume: 24
  start-page: 2294
  year: 2010
  end-page: 2302
  ident: bib47
  article-title: Error-prone polyploid mitosis during normal Drosophila development
  publication-title: Genes Dev.
– volume: 31
  start-page: 34
  year: 2017
  end-page: 45
  ident: bib93
  article-title: The PIDDosome activates p53 in response to supernumerary centrosomes
  publication-title: Genes Dev.
– volume: 22
  start-page: 1690
  year: 2008
  end-page: 1703
  ident: bib18
  article-title: The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles
  publication-title: Genes Dev.
– volume: 50
  start-page: 1189
  year: 2018
  end-page: 1195
  ident: bib96
  article-title: Genome doubling shapes the evolution and prognosis of advanced cancers
  publication-title: Nat. Genet.
– volume: 158
  start-page: 833
  year: 2014
  end-page: 848
  ident: bib90
  article-title: Cytokinesis failure triggers hippo tumor suppressor pathway activation
  publication-title: Cell
– volume: 17
  start-page: 431
  year: 2007
  end-page: 437
  ident: bib111
  article-title: A virus causes cancer by inducing massive chromosomal instability through cell fusion
  publication-title: Curr. Biol.
– volume: 257
  start-page: 65
  year: 2007
  end-page: 72
  ident: bib117
  article-title: Suppression of polyploidy by the BRCA2 protein
  publication-title: Cancer Lett.
– volume: 145
  year: 2018
  ident: bib15
  article-title: Polyploidy in tissue homeostasis and regeneration
  publication-title: Development
– volume: 9
  year: 2020
  ident: bib81
  article-title: Polyploidy in the adult Drosophila brain
  publication-title: Elife
– volume: 81
  start-page: 1
  year: 2022
  end-page: 4
  ident: bib38
  article-title: Polyploid giant cancer cells: an emerging new field of cancer biology
  publication-title: Semin Cancer Biol.
– volume: 69
  start-page: 2296
  year: 2009
  end-page: 2304
  ident: bib148
  article-title: Activation of meiosis-specific genes is associated with depolyploidization of human tumor cells following radiation-induced mitotic catastrophe
  publication-title: Cancer Res.
– volume: 182
  start-page: 423
  year: 2009
  end-page: 435
  ident: bib44
  article-title: p53-independent apoptosis limits DNA damage-induced aneuploidy
  publication-title: Genetics
– volume: 8
  start-page: 235
  year: 1998
  end-page: 238
  ident: bib17
  article-title: Fluctuations in cyclin E levels are required for multiple rounds of endocycle S phase in Drosophila
  publication-title: Curr. Biol.
– volume: 7
  start-page: 968
  year: 2007
  end-page: 976
  ident: bib110
  article-title: Cell-to-cell fusion as a link between viruses and cancer
  publication-title: Nat. Rev. Cancer
– volume: 27
  start-page: 2911
  year: 2016
  end-page: 2923
  ident: bib102
  article-title: Transient endoreplication down-regulates the kinesin-14 HSET and contributes to genomic instability
  publication-title: Mol. Biol. Cell
– volume: 144
  start-page: 9
  year: 2011
  end-page: 10
  ident: bib106
  article-title: Cancer genomes evolve by pulverizing single chromosomes
  publication-title: Cell
– volume: 148
  year: 2021
  ident: bib9
  article-title: Polyploid cardiomyocytes: implications for heart regeneration
  publication-title: Development
– volume: 123
  start-page: 4095
  year: 2010
  end-page: 4106
  ident: bib23
  article-title: Dampened activity of E2F1-DP and Myb-MuvB transcription factors in Drosophila endocycling cells
  publication-title: J. Cell Sci.
– volume: 52
  start-page: 68
  year: 2020
  end-page: 75
  ident: bib147
  article-title: Senescence in polyploid giant cancer cells: a road that leads to chemoresistance
  publication-title: Cytokine Growth Factor Rev.
– volume: 60
  start-page: 151
  year: 1975
  end-page: 219
  ident: bib143
  article-title: DNA in human tumors: a cytophotometric study
  publication-title: Curr. Top. Pathol.
– volume: 24
  start-page: 2420
  year: 2010
  end-page: 2429
  ident: bib130
  article-title: The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1
  publication-title: Genes Dev.
– volume: 13
  year: 2021
  ident: bib32
  article-title: Polyploidy in tissue repair and regeneration
  publication-title: Cold Spring Harb. Perspect. Biol.
– volume: 27
  start-page: 585
  year: 2011
  end-page: 610
  ident: bib108
  article-title: The causes and consequences of polyploidy in normal development and cancer
  publication-title: Annu Rev. Cell Dev. Biol.
– volume: 37
  start-page: 444
  year: 2016
  end-page: 457
  ident: bib49
  article-title: Proliferation of double-strand break-resistant polyploid cells requires drosophila FANCD2
  publication-title: Dev. Cell
– volume: 141
  start-page: 112
  year: 2014
  end-page: 123
  ident: bib75
  article-title: Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability
  publication-title: Development
– volume: 141
  start-page: 81
  year: 2010
  end-page: 93
  ident: bib114
  article-title: Persistent telomere damage induces bypass of mitosis and tetraploidy
  publication-title: Cell
– volume: 30
  start-page: 688
  year: 2020
  end-page: 694
  ident: bib7
  article-title: Polyploidy: a biological force from cells to ecosystems
  publication-title: Trends Cell Biol.
– volume: 140
  start-page: 3
  year: 2013
  end-page: 12
  ident: bib5
  article-title: Endoreplication and polyploidy: insights into development and disease
  publication-title: Development
– volume: 141
  start-page: 3551
  year: 2014
  end-page: 3560
  ident: bib48
  article-title: Indispensable pre-mitotic endocycles promote aneuploidy in the Drosophila rectum
  publication-title: Development
– volume: 29
  start-page: 1084
  year: 2005
  end-page: 1097
  ident: bib149
  article-title: Neosis--a paradigm of self-renewal in cancer
  publication-title: Cell Biol. Int.
– volume: 33
  start-page: 116
  year: 2014
  end-page: 128
  ident: bib152
  article-title: Generation of cancer stem-like cells through the formation of polyploid giant cancer cells
  publication-title: Oncogene
– volume: 90
  start-page: 671
  year: 1997
  end-page: 681
  ident: bib13
  article-title: Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles
  publication-title: Cell
– volume: 25
  start-page: 2584
  year: 2006
  end-page: 2595
  ident: bib91
  article-title: Apoptosis regulation in tetraploid cancer cells
  publication-title: EMBO J.
– volume: 14
  start-page: 1192
  year: 2012
  end-page: 1202
  ident: bib24
  article-title: Canonical and atypical E2Fs regulate the mammalian endocycle
  publication-title: Nat. Cell Biol.
– volume: 121
  start-page: 1
  year: 2008
  end-page: 84
  ident: bib34
  article-title: Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris
  publication-title: J. Cell Sci.
– volume: 124
  start-page: 3555
  year: 1997
  end-page: 3563
  ident: bib77
  article-title: Cell cycle progression, growth and patterning in imaginal discs despite inhibition of cell division after inactivation of Drosophila Cdc2 kinase
  publication-title: Development
– volume: 460
  start-page: 278
  year: 2009
  end-page: 282
  ident: bib101
  article-title: A mechanism linking extra centrosomes to chromosomal instability
  publication-title: Nature
– volume: 23
  year: 2022
  ident: bib10
  article-title: Implications of polyploidy and ploidy alterations in hepatocytes in liver injuries and cancers
  publication-title: Int. J. Mol. Sci.
– volume: 44
  start-page: 433
  year: 2018
  end-page: 446
  ident: bib36
  article-title: Myocardial polyploidization creates a barrier to heart regeneration in zebrafish
  publication-title: Dev. Cell
– volume: 117
  start-page: 411
  year: 2008
  end-page: 418
  ident: bib62
  article-title: Intercalary heterochromatin in polytene chromosomes of Drosophila melanogaster
  publication-title: Chromosoma
– volume: 1167
  start-page: 105
  year: 2019
  end-page: 112
  ident: bib42
  article-title: P53 and apoptosis in the drosophila model
  publication-title: Adv. Exp. Med. Biol.
– volume: 29
  start-page: 3937
  year: 2019
  end-page: 3945
  ident: bib137
  article-title: Cell-cycle asynchrony generates DNA damage at mitotic entry in polyploid cells
  publication-title: Curr. Biol.
– volume: 4
  year: 2017
  ident: bib87
  article-title: Caspase 2 in mitotic catastrophe: The terminator of aneuploid and tetraploid cells
  publication-title: Mol. Cell Oncol.
– volume: 6
  year: 2017
  ident: bib128
  article-title: The consequences of chromosome segregation errors in mitosis and meiosis
  publication-title: Biology (Basel)
– volume: 12
  start-page: 1039
  year: 2021
  ident: bib94
  article-title: Paradoxical implication of BAX/BAK in the persistence of tetraploid cells
  publication-title: Cell Death Dis.
– volume: 176
  start-page: 183
  year: 2007
  end-page: 195
  ident: bib133
  article-title: Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis
  publication-title: J. Cell Biol.
– volume: 40
  year: 2021
  ident: bib138
  article-title: Cancer evolution: Darwin and beyond
  publication-title: EMBO J.
– volume: 118
  year: 2021
  ident: bib115
  article-title: Cancer recurrence and lethality are enabled by enhanced survival and reversible cell cycle arrest of polyaneuploid cells
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 27
  start-page: 4411
  year: 2008
  end-page: 4421
  ident: bib132
  article-title: Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug-induced polyploidy
  publication-title: Oncogene
– volume: 9
  year: 2014
  ident: bib53
  article-title: Cytoplasmic localization of p21 protects trophoblast giant cells from DNA damage induced apoptosis
  publication-title: PLoS One
– volume: 22
  start-page: 3024
  year: 2008
  end-page: 3036
  ident: bib51
  article-title: Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity
  publication-title: Genes Dev.
– volume: 207
  start-page: 29
  year: 2017
  end-page: 47
  ident: bib65
  article-title: DNA Replication Control During Drosophila Development: Insights Into The Onset Of S Phase, Replication Initiation, And Fork Progression
  publication-title: Genetics
– volume: 44
  start-page: 638
  year: 2012
  end-page: 650
  ident: bib57
  article-title: Proposed megakaryocytic regulon of p53: the genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation
  publication-title: Physiol. Genom.
– volume: 49
  start-page: 461
  year: 2019
  end-page: 472
  ident: bib113
  article-title: Oncogenic notch triggers neoplastic tumorigenesis in a transition-zone-like tissue microenvironment
  publication-title: Dev. Cell
– volume: 18
  start-page: 1403
  year: 2011
  end-page: 1413
  ident: bib84
  article-title: Illicit survival of cancer cells during polyploidization and depolyploidization
  publication-title: Cell Death Differ.
– volume: 41
  start-page: 42
  year: 2021
  end-page: 49
  ident: bib69
  article-title: Differential roles for diploid and polyploid hepatocytes in acute and chronic liver injury
  publication-title: Semin Liver Dis.
– volume: 590
  start-page: 492
  year: 2021
  end-page: 497
  ident: bib139
  article-title: Whole-genome doubling confers unique genetic vulnerabilities on tumour cells
  publication-title: Nature
– volume: 24
  start-page: 621
  year: 2000
  end-page: 633
  ident: bib141
  article-title: Polyploid giant cells provide a survival mechanism for p53 mutant cells after DNA damage
  publication-title: Cell Biol. Int.
– volume: 23
  start-page: 2224
  year: 2013
  end-page: 2232
  ident: bib28
  article-title: Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium
  publication-title: Curr. Biol.
– volume: 608
  start-page: 795
  year: 2022
  end-page: 802
  ident: bib126
  article-title: Ordered and deterministic cancer genome evolution after p53 loss
  publication-title: Nature
– volume: 7
  year: 2018
  ident: bib30
  article-title: Fizzy-related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut
  publication-title: Elife
– volume: 4
  start-page: 175
  year: 2014
  end-page: 185
  ident: bib107
  article-title: Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution
  publication-title: Cancer Discov.
– volume: 16
  start-page: 20
  year: 2016
  end-page: 33
  ident: bib3
  article-title: DNA damage and the balance between survival and death in cancer biology
  publication-title: Nat. Rev. Cancer
– volume: 430
  start-page: 757
  year: 2013
  end-page: 762
  ident: bib21
  article-title: The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells
  publication-title: Biochem Biophys. Res. Commun.
– volume: 26
  start-page: 34
  year: 2020
  end-page: 47
  ident: bib71
  article-title: In vivo lineage tracing of polyploid hepatocytes reveals extensive proliferation during liver regeneration
  publication-title: Cell Stem Cell
– volume: 26
  start-page: 239
  year: 1972
  end-page: 257
  ident: bib1
  article-title: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
  publication-title: Br. J. Cancer
– volume: 178
  start-page: 85
  year: 2007
  end-page: 92
  ident: bib59
  article-title: Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death
  publication-title: J. Cell Biol.
– volume: 10
  start-page: 478
  year: 2009
  end-page: 487
  ident: bib35
  article-title: Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
  publication-title: Nat. Rev. Mol. Cell Biol.
– volume: 81
  start-page: 145
  year: 2022
  end-page: 159
  ident: bib37
  article-title: Cancer cells employ an evolutionarily conserved polyploidization program to resist therapy
  publication-title: Semin Cancer Biol.
– volume: 130
  start-page: 2495
  year: 2012
  end-page: 2504
  ident: bib118
  article-title: Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells
  publication-title: Int J. Cancer
– volume: 23
  start-page: 2825
  year: 2004
  end-page: 2837
  ident: bib86
  article-title: Cell death by mitotic catastrophe: a molecular definition
  publication-title: Oncogene
– volume: 31
  start-page: 707
  year: 2020
  end-page: 716
  ident: bib54
  article-title: Megakaryocyte polyploidization: role in platelet production
  publication-title: Platelets
– volume: 135
  start-page: 1451
  year: 2008
  end-page: 1461
  ident: bib19
  article-title: APC/CFzr/Cdh1 promotes cell cycle progression during the Drosophila endocycle
  publication-title: Development
– volume: 1
  start-page: 1
  year: 2001
  ident: bib142
  article-title: Mitotic death: a mechanism of survival? A review
  publication-title: Cancer Cell Int
– volume: 13
  year: 2022
  ident: bib154
  article-title: Impact of polyploidy on plant tolerance to abiotic and biotic stresses
  publication-title: Front Plant Sci.
– volume: 39
  start-page: 12
  year: 2015
  end-page: 19
  ident: bib4
  article-title: Cell death in development: Signaling pathways and core mechanisms
  publication-title: Semin Cell Dev. Biol.
– volume: 186
  start-page: 528
  year: 2023
  end-page: 542
  ident: bib127
  article-title: Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication
  publication-title: Cell
– volume: 3
  start-page: 815
  year: 2012
  ident: bib153
  article-title: Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression
  publication-title: Nat. Commun.
– volume: 21
  start-page: 175
  year: 2011
  end-page: 181
  ident: bib66
  article-title: Developmental control of the DNA replication and transcription programs
  publication-title: Genome Res
– volume: 15
  year: 2019
  ident: bib16
  article-title: A-Myb-MuvB-Aurora B network regulates the choice between mitotic cycles and polyploid endoreplication cycles
  publication-title: PLoS Genet.
– volume: 12
  start-page: 829
  year: 2002
  end-page: 833
  ident: bib76
  article-title: Sister chromatids fail to separate during an induced endoreplication cycle in Drosophila embryos
  publication-title: Curr. Biol.
– volume: 482
  start-page: 53
  year: 2012
  end-page: 58
  ident: bib104
  article-title: DNA breaks and chromosome pulverization from errors in mitosis
  publication-title: Nature
– volume: 21
  start-page: 765
  year: 2012
  end-page: 776
  ident: bib103
  article-title: Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells
  publication-title: Cancer Cell
– volume: 23
  start-page: 4362
  year: 2004
  end-page: 4370
  ident: bib92
  article-title: Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy
  publication-title: Oncogene
– volume: 28
  start-page: 1840
  year: 2014
  end-page: 1855
  ident: bib63
  article-title: Incomplete replication generates somatic DNA alterations within Drosophila polytene salivary gland cells
  publication-title: Genes Dev.
– volume: 122
  start-page: 2579
  year: 2009
  end-page: 2585
  ident: bib89
  article-title: How do anti-mitotic drugs kill cancer cells?
  publication-title: J. Cell Sci.
– volume: 26
  start-page: 2971
  year: 2015
  end-page: 2985
  ident: bib119
  article-title: Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition
  publication-title: Mol. Biol. Cell
– volume: 110
  start-page: 9621
  year: 2013
  end-page: 9622
  ident: bib6
  article-title: Making big cells: one size does not fit all
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 12
  start-page: 1315
  year: 2001
  end-page: 1328
  ident: bib83
  article-title: Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1
  publication-title: Mol. Biol. Cell
– volume: 103
  start-page: 9952
  year: 2006
  end-page: 9957
  ident: bib43
  article-title: Ionizing radiation induces caspase-dependent but Chk2- and p53-independent cell death in Drosophila melanogaster
  publication-title: Proc. Natl. Acad. Sci. U. S. A
– volume: 25
  start-page: 486
  year: 2018
  end-page: 541
  ident: bib2
  article-title: Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
  publication-title: Cell Death Differ.
– volume: 5
  year: 2016
  ident: bib140
  article-title: Distinct responses to reduplicated chromosomes require distinct Mad2 responses
  publication-title: Elife
– volume: 11
  start-page: 342
  year: 2020
  ident: bib22
  article-title: Transcriptomic analysis reveals differential gene expression, alternative splicing, and novel exons during mouse trophoblast stem cell differentiation
  publication-title: Stem Cell Res. Ther.
– volume: 62
  start-page: 7316
  year: 2002
  end-page: 7327
  ident: bib50
  article-title: Tissue-specific induction of p53 targets in vivo
  publication-title: Cancer Res.
– volume: 38
  start-page: 787
  year: 2022
  end-page: 788
  ident: bib135
  article-title: Catastrophic DNA replication in unscheduled tetraploid cells
  publication-title: Trends Genet
– volume: 122
  start-page: 1051
  year: 1996
  end-page: 1058
  ident: bib78
  article-title: dependent checkpoint maintains diploidy in Drosophila
  publication-title: Development
– volume: 14
  start-page: 111
  year: 2008
  end-page: 122
  ident: bib88
  article-title: Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs
  publication-title: Cancer Cell
– volume: 32
  start-page: 1031
  year: 2008
  end-page: 1043
  ident: bib116
  article-title: Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy
  publication-title: Cell Biol. Int.
– volume: 42
  start-page: 600
  year: 2017
  end-page: 615
  ident: bib27
  article-title: Tension creates an endoreplication wavefront that leads regeneration of epicardial tissue
  publication-title: Dev. Cell
– volume: 50
  start-page: 710
  year: 1990
  end-page: 716
  ident: bib123
  article-title: Development of polyploidization in taxol-resistant human leukemia cells in vitro
  publication-title: Cancer Res.
– volume: 50
  start-page: 175
  year: 1975
  end-page: 179
  ident: bib64
  article-title: Differential replication of satellite DNA in polyploid tissues of Drosophila virilis
  publication-title: Chromosoma
– volume: 9
  start-page: 294
  year: 2011
  end-page: 310
  ident: bib120
  article-title: An image-based, high-throughput screening assay for molecules that induce excess DNA replication in human cancer cells
  publication-title: Mol. Cancer Res.
– volume: 108
  start-page: 10004
  year: 2011
  end-page: 10009
  ident: bib155
  article-title: Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 369
  start-page: 2014
  year: 1650
  ident: bib100
  article-title: Causes and consequences of centrosome abnormalities in cancer
  publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci.
– volume: 27
  start-page: 1885
  year: 2016
  end-page: 1897
  ident: bib79
  article-title: Different cell cycle modifications repress apoptosis at different steps independent of developmental signaling in Drosophila
  publication-title: Mol. Biol. Cell
– volume: 10
  year: 2014
  ident: bib68
  article-title: Copy number variation is a fundamental aspect of the placental genome
  publication-title: PLoS Genet.
– volume: 29
  start-page: 1005
  year: 2005
  end-page: 1011
  ident: bib150
  article-title: Segregation of genomes in polyploid tumour cells following mitotic catastrophe
  publication-title: Cell Biol. Int.
– volume: 14
  start-page: 1181
  year: 2012
  end-page: 1191
  ident: bib25
  article-title: E2F8 is essential for polyploidization in mammalian cells
  publication-title: Nat. Cell Biol.
– volume: 206
  start-page: 37
  year: 2013
  end-page: 41
  ident: bib121
  article-title: Change in HER2 (ERBB2) gene status after taxane-based chemotherapy for breast cancer: polyploidization can lead to diagnostic pitfalls with potential impact for clinical management
  publication-title: Cancer Genet.
– volume: 10
  year: 2014
  ident: bib46
  article-title: Low Levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in drosophila endocycling cells
  publication-title: PLoS Genet
– volume: 3
  start-page: 1371
  year: 1997
  end-page: 1381
  ident: bib144
  article-title: Inhibition of radiation-induced G2 delay potentiates cell death by apoptosis and/or the induction of giant cells in colorectal tumor cells with disrupted p53 function
  publication-title: Clin. Cancer Res
– volume: 5
  year: 2013
  ident: bib12
  article-title: Endoreplication
  publication-title: Cold Spring Harb. Perspect. Biol.
– volume: 25
  start-page: 29
  year: 2004
  end-page: 36
  ident: bib52
  article-title: Differentiation of placental trophoblast giant cells requires downregulation of p53 and Rb
  publication-title: Placenta
– volume: 13
  year: 2018
  ident: bib58
  article-title: Role of p53 and transcription-independent p53-induced apoptosis in shear-stimulated megakaryocytic maturation, particle generation, and platelet biogenesis
  publication-title: PLoS One
– volume: 88
  start-page: 673
  year: 2003
  end-page: 683
  ident: bib82
  article-title: G1 tetraploidy checkpoint and the suppression of tumorigenesis
  publication-title: J. Cell Biochem.
– volume: 144
  start-page: 27
  year: 2011
  end-page: 40
  ident: bib105
  article-title: Massive genomic rearrangement acquired in a single catastrophic event during cancer development
  publication-title: Cell
– volume: 35
  start-page: 6
  year: 2019
  end-page: 14
  ident: bib74
  article-title: Solving the polyploid mystery in health and disease
  publication-title: Trends Genet
– volume: 381
  start-page: 713
  year: 1996
  end-page: 716
  ident: bib145
  article-title: Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
  publication-title: Nature
– volume: 101
  start-page: 1469
  year: 2016
  end-page: 1478
  ident: bib56
  article-title: Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint
  publication-title: Haematologica
– volume: 17
  start-page: 91
  year: 2008
  end-page: 101
  ident: bib60
  article-title: Genes and biological processes controlled by the Drosophila FOXA orthologue Fork head
  publication-title: Insect Mol. Biol.
– volume: 110
  start-page: 9368
  year: 2013
  end-page: 9373
  ident: bib67
  article-title: Fundamental differences in endoreplication in mammals and Drosophila revealed by analysis of endocycling and endomitotic cells
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 75
  start-page: 1177
  year: 2021
  end-page: 1191
  ident: bib70
  article-title: Polyploidy control in hepatic health and disease
  publication-title: J. Hepatol.
– volume: 21
  start-page: 44
  year: 2020
  end-page: 62
  ident: bib99
  article-title: Context is everything: aneuploidy in cancer
  publication-title: Nat. Rev. Genet.
– volume: 20
  start-page: 2687
  year: 2006
  end-page: 2700
  ident: bib131
  article-title: A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization
  publication-title: Genes Dev.
– volume: 24
  start-page: 635
  year: 2000
  end-page: 648
  ident: bib151
  article-title: Release of mitotic descendants by giant cells from irradiated Burkitt's lymphoma cell line
  publication-title: Cell Biol. Int.
– volume: 36
  start-page: 843
  year: 2022
  end-page: 856
  ident: bib95
  article-title: Centriole signaling restricts hepatocyte ploidy to maintain liver integrity
  publication-title: Genes Dev.
– volume: 10
  start-page: 2514
  year: 1996
  end-page: 2526
  ident: bib20
  article-title: The Drosophila endocycle is controlled by Cyclin E and lacks a checkpoint ensuring S-phase completion
  publication-title: Genes Dev.
– volume: 22
  start-page: 3158
  year: 2008
  end-page: 3171
  ident: bib45
  article-title: Endocycling cells do not apoptose in response to DNA rereplication genotoxic stress
  publication-title: Genes Dev.
– volume: 32
  start-page: 155
  year: 2015
  end-page: 167
  ident: bib55
  article-title: Functional reprogramming of polyploidization in megakaryocytes
  publication-title: Dev. Cell
– volume: 154
  start-page: 82
  year: 2018
  end-page: 90
  ident: bib39
  article-title: Regulation and function of p53: a perspective from Drosophila studies
  publication-title: Mech. Dev.
– volume: 5
  start-page: 315
  year: 2011
  end-page: 323
  ident: bib125
  article-title: p53: guardian of ploidy
  publication-title: Mol. Oncol.
– volume: 8
  start-page: 3172
  year: 2009
  end-page: 3181
  ident: bib134
  article-title: The aurora B kinase inhibitor AZD1152 sensitizes cancer cells to fractionated irradiation and induces mitotic catastrophe
  publication-title: Cell Cycle
– volume: 45
  start-page: 1134
  year: 2013
  end-page: 1140
  ident: bib97
  article-title: Pan-cancer patterns of somatic copy number alteration
  publication-title: Nat. Genet.
– volume: 23
  start-page: 621
  year: 1993
  end-page: 629
  ident: bib122
  article-title: Antimicrotubule agents induce polyploidization of human leukaemic cell lines with megakaryocytic features
  publication-title: Eur. J. Clin. Invest.
– volume: 28
  start-page: 149
  year: 2017
  end-page: 156
  ident: bib129
  article-title: Cyclin D mediates tolerance of genome-doubling in cancers with functional p53
  publication-title: Ann. Oncol.
– volume: 146
  year: 2019
  ident: bib80
  article-title: Wound-induced polyploidization is driven by Myc and supports tissue repair in the presence of DNA damage
  publication-title: Development
– volume: 437
  start-page: 1043
  year: 2005
  end-page: 1047
  ident: bib98
  article-title: Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
  publication-title: Nature
– volume: 8
  start-page: 1501
  year: 2009
  end-page: 1509
  ident: bib8
  article-title: Developmentally programmed endoreduplication in animals
  publication-title: Cell Cycle
– volume: 11
  year: 2016
  ident: bib29
  article-title: Wound-induced polyploidization: regulation by hippo and jnk signaling and conservation in mammals
  publication-title: PLoS One
– volume: 30
  start-page: 639
  year: 2016
  end-page: 644
  ident: bib31
  article-title: Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in Fan1 nuclease-defective knock-in mice
  publication-title: Genes Dev.
– volume: 101
  start-page: 91
  year: 2000
  end-page: 101
  ident: bib40
  article-title: Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
  publication-title: Cell
– volume: 604
  start-page: 146
  year: 2022
  end-page: 151
  ident: bib136
  article-title: Genetic instability from a single S phase after whole-genome duplication
  publication-title: Nature
– volume: 81
  start-page: 106
  year: 2022
  end-page: 118
  ident: bib109
  article-title: Polyploidy in development and tumor models in Drosophila
  publication-title: Semin Cancer Biol.
– volume: 33
  start-page: 124
  year: 2011
  end-page: 134
  ident: bib14
  article-title: At the crossroads of differentiation and proliferation: precise control of cell-cycle changes by multiple signaling pathways in Drosophila follicle cells
  publication-title: Bioessays
– volume: 97
  start-page: 7301
  year: 2000
  end-page: 7306
  ident: bib41
  article-title: Identification and characterization of a p53 homologue in Drosophila melanogaster
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 14
  start-page: 1
  year: 1953
  end-page: 43
  ident: bib33
  article-title: Endomitotic reduplication mechanisms in ascites tumors of the mouse
  publication-title: J. Natl. Cancer Inst.
– volume: 131
  start-page: 275
  year: 2004
  end-page: 284
  ident: bib61
  article-title: Caspases function in autophagic programmed cell death in Drosophila
  publication-title: Development
– volume: 175
  start-page: 200
  year: 2018
  end-page: 211
  ident: bib73
  article-title: Chromosome segregation fidelity in epithelia requires tissue architecture
  publication-title: Cell
– volume: 2015
  year: 2015
  ident: bib85
  article-title: Targeting the mitotic catastrophe signaling pathway in cancer
  publication-title: Mediat. Inflamm.
– volume: 56
  start-page: 1976
  year: 2021
  end-page: 1988
  ident: bib112
  article-title: Polyploid mitosis and depolyploidization promote chromosomal instability and tumor progression in a Notch-induced tumor model
  publication-title: Dev. Cell
– volume: 111
  start-page: 13409
  year: 2014
  end-page: 13414
  ident: bib72
  article-title: Single cell sequencing reveals low levels of aneuploidy across mammalian tissues
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 209
  start-page: 485
  year: 2015
  end-page: 491
  ident: bib26
  article-title: The expanding implications of polyploidy
  publication-title: J. Cell Biol.
– volume: 29
  start-page: 245
  year: 2021
  end-page: 260
  ident: bib11
  article-title: Communal living: the role of polyploidy and syncytia in tissue biology
  publication-title: Chromosome Res.
– volume: 6
  issue: 1
  year: 2017
  ident: 10.1016/j.semcdb.2023.05.009_bib128
  article-title: The consequences of chromosome segregation errors in mitosis and meiosis
  publication-title: Biology (Basel)
– volume: 81
  start-page: 145
  year: 2022
  ident: 10.1016/j.semcdb.2023.05.009_bib37
  article-title: Cancer cells employ an evolutionarily conserved polyploidization program to resist therapy
  publication-title: Semin Cancer Biol.
  doi: 10.1016/j.semcancer.2020.11.016
– volume: 23
  start-page: 2825
  issue: 16
  year: 2004
  ident: 10.1016/j.semcdb.2023.05.009_bib86
  article-title: Cell death by mitotic catastrophe: a molecular definition
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1207528
– volume: 130
  start-page: 2495
  issue: 11
  year: 2012
  ident: 10.1016/j.semcdb.2023.05.009_bib118
  article-title: Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells
  publication-title: Int J. Cancer
  doi: 10.1002/ijc.26309
– volume: 11
  start-page: 342
  issue: 1
  year: 2020
  ident: 10.1016/j.semcdb.2023.05.009_bib22
  article-title: Transcriptomic analysis reveals differential gene expression, alternative splicing, and novel exons during mouse trophoblast stem cell differentiation
  publication-title: Stem Cell Res. Ther.
  doi: 10.1186/s13287-020-01848-8
– volume: 257
  start-page: 65
  issue: 1
  year: 2007
  ident: 10.1016/j.semcdb.2023.05.009_bib117
  article-title: Suppression of polyploidy by the BRCA2 protein
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2007.07.003
– volume: 590
  start-page: 492
  issue: 7846
  year: 2021
  ident: 10.1016/j.semcdb.2023.05.009_bib139
  article-title: Whole-genome doubling confers unique genetic vulnerabilities on tumour cells
  publication-title: Nature
  doi: 10.1038/s41586-020-03133-3
– volume: 7
  start-page: 968
  issue: 12
  year: 2007
  ident: 10.1016/j.semcdb.2023.05.009_bib110
  article-title: Cell-to-cell fusion as a link between viruses and cancer
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc2272
– volume: 20
  start-page: 2687
  issue: 19
  year: 2006
  ident: 10.1016/j.semcdb.2023.05.009_bib131
  article-title: A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization
  publication-title: Genes Dev.
  doi: 10.1101/gad.1447006
– volume: 122
  start-page: 1051
  issue: 4
  year: 1996
  ident: 10.1016/j.semcdb.2023.05.009_bib78
  article-title: dependent checkpoint maintains diploidy in Drosophila
  publication-title: Development
  doi: 10.1242/dev.122.4.1051
– volume: 1
  start-page: 1
  issue: 1
  year: 2001
  ident: 10.1016/j.semcdb.2023.05.009_bib142
  article-title: Mitotic death: a mechanism of survival? A review
  publication-title: Cancer Cell Int
  doi: 10.1186/1475-2867-1-1
– volume: 36
  start-page: 843
  issue: 13–14
  year: 2022
  ident: 10.1016/j.semcdb.2023.05.009_bib95
  article-title: Centriole signaling restricts hepatocyte ploidy to maintain liver integrity
  publication-title: Genes Dev.
  doi: 10.1101/gad.349727.122
– volume: 23
  issue: 16
  year: 2022
  ident: 10.1016/j.semcdb.2023.05.009_bib10
  article-title: Implications of polyploidy and ploidy alterations in hepatocytes in liver injuries and cancers
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms23169409
– volume: 8
  start-page: 235
  issue: 4
  year: 1998
  ident: 10.1016/j.semcdb.2023.05.009_bib17
  article-title: Fluctuations in cyclin E levels are required for multiple rounds of endocycle S phase in Drosophila
  publication-title: Curr. Biol.
  doi: 10.1016/S0960-9822(98)70089-2
– volume: 10
  start-page: 2514
  year: 1996
  ident: 10.1016/j.semcdb.2023.05.009_bib20
  article-title: The Drosophila endocycle is controlled by Cyclin E and lacks a checkpoint ensuring S-phase completion
  publication-title: Genes Dev.
  doi: 10.1101/gad.10.19.2514
– volume: 75
  start-page: 1177
  issue: 5
  year: 2021
  ident: 10.1016/j.semcdb.2023.05.009_bib70
  article-title: Polyploidy control in hepatic health and disease
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2021.06.030
– volume: 12
  start-page: 1039
  issue: 11
  year: 2021
  ident: 10.1016/j.semcdb.2023.05.009_bib94
  article-title: Paradoxical implication of BAX/BAK in the persistence of tetraploid cells
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-021-04321-3
– volume: 11
  issue: 3
  year: 2016
  ident: 10.1016/j.semcdb.2023.05.009_bib29
  article-title: Wound-induced polyploidization: regulation by hippo and jnk signaling and conservation in mammals
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0151251
– volume: 38
  start-page: 787
  issue: 8
  year: 2022
  ident: 10.1016/j.semcdb.2023.05.009_bib135
  article-title: Catastrophic DNA replication in unscheduled tetraploid cells
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2022.04.005
– volume: 175
  start-page: 200
  issue: 1
  year: 2018
  ident: 10.1016/j.semcdb.2023.05.009_bib73
  article-title: Chromosome segregation fidelity in epithelia requires tissue architecture
  publication-title: Cell
  doi: 10.1016/j.cell.2018.07.042
– volume: 110
  start-page: 9368
  issue: 23
  year: 2013
  ident: 10.1016/j.semcdb.2023.05.009_bib67
  article-title: Fundamental differences in endoreplication in mammals and Drosophila revealed by analysis of endocycling and endomitotic cells
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1304889110
– volume: 31
  start-page: 34
  issue: 1
  year: 2017
  ident: 10.1016/j.semcdb.2023.05.009_bib93
  article-title: The PIDDosome activates p53 in response to supernumerary centrosomes
  publication-title: Genes Dev.
  doi: 10.1101/gad.289728.116
– volume: 37
  start-page: 444
  issue: 5
  year: 2016
  ident: 10.1016/j.semcdb.2023.05.009_bib49
  article-title: Proliferation of double-strand break-resistant polyploid cells requires drosophila FANCD2
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2016.05.004
– volume: 12
  start-page: 829
  issue: 10
  year: 2002
  ident: 10.1016/j.semcdb.2023.05.009_bib76
  article-title: Sister chromatids fail to separate during an induced endoreplication cycle in Drosophila embryos
  publication-title: Curr. Biol.
  doi: 10.1016/S0960-9822(02)00845-X
– volume: 40
  issue: 18
  year: 2021
  ident: 10.1016/j.semcdb.2023.05.009_bib138
  article-title: Cancer evolution: Darwin and beyond
  publication-title: EMBO J.
  doi: 10.15252/embj.2021108389
– volume: 23
  start-page: 4362
  issue: 25
  year: 2004
  ident: 10.1016/j.semcdb.2023.05.009_bib92
  article-title: Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1207572
– volume: 81
  start-page: 106
  year: 2022
  ident: 10.1016/j.semcdb.2023.05.009_bib109
  article-title: Polyploidy in development and tumor models in Drosophila
  publication-title: Semin Cancer Biol.
  doi: 10.1016/j.semcancer.2021.09.011
– volume: 14
  start-page: 1192
  issue: 11
  year: 2012
  ident: 10.1016/j.semcdb.2023.05.009_bib24
  article-title: Canonical and atypical E2Fs regulate the mammalian endocycle
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2595
– volume: 29
  start-page: 1084
  issue: 12
  year: 2005
  ident: 10.1016/j.semcdb.2023.05.009_bib149
  article-title: Neosis--a paradigm of self-renewal in cancer
  publication-title: Cell Biol. Int.
  doi: 10.1016/j.cellbi.2005.10.003
– volume: 32
  start-page: 155
  issue: 2
  year: 2015
  ident: 10.1016/j.semcdb.2023.05.009_bib55
  article-title: Functional reprogramming of polyploidization in megakaryocytes
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2014.12.015
– volume: 123
  start-page: 4095
  issue: Pt 23
  year: 2010
  ident: 10.1016/j.semcdb.2023.05.009_bib23
  article-title: Dampened activity of E2F1-DP and Myb-MuvB transcription factors in Drosophila endocycling cells
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.064519
– volume: 141
  start-page: 3551
  issue: 18
  year: 2014
  ident: 10.1016/j.semcdb.2023.05.009_bib48
  article-title: Indispensable pre-mitotic endocycles promote aneuploidy in the Drosophila rectum
  publication-title: Development
  doi: 10.1242/dev.109850
– volume: 9
  start-page: 294
  issue: 3
  year: 2011
  ident: 10.1016/j.semcdb.2023.05.009_bib120
  article-title: An image-based, high-throughput screening assay for molecules that induce excess DNA replication in human cancer cells
  publication-title: Mol. Cancer Res.
  doi: 10.1158/1541-7786.MCR-10-0570
– volume: 88
  start-page: 673
  issue: 4
  year: 2003
  ident: 10.1016/j.semcdb.2023.05.009_bib82
  article-title: G1 tetraploidy checkpoint and the suppression of tumorigenesis
  publication-title: J. Cell Biochem.
  doi: 10.1002/jcb.10411
– volume: 24
  start-page: 621
  issue: 9
  year: 2000
  ident: 10.1016/j.semcdb.2023.05.009_bib141
  article-title: Polyploid giant cells provide a survival mechanism for p53 mutant cells after DNA damage
  publication-title: Cell Biol. Int.
  doi: 10.1006/cbir.2000.0557
– volume: 13
  year: 2022
  ident: 10.1016/j.semcdb.2023.05.009_bib154
  article-title: Impact of polyploidy on plant tolerance to abiotic and biotic stresses
  publication-title: Front Plant Sci.
  doi: 10.3389/fpls.2022.869423
– volume: 49
  start-page: 461
  issue: 3
  year: 2019
  ident: 10.1016/j.semcdb.2023.05.009_bib113
  article-title: Oncogenic notch triggers neoplastic tumorigenesis in a transition-zone-like tissue microenvironment
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2019.03.015
– volume: 44
  start-page: 638
  issue: 12
  year: 2012
  ident: 10.1016/j.semcdb.2023.05.009_bib57
  article-title: Proposed megakaryocytic regulon of p53: the genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation
  publication-title: Physiol. Genom.
  doi: 10.1152/physiolgenomics.00028.2012
– volume: 13
  issue: 10
  year: 2021
  ident: 10.1016/j.semcdb.2023.05.009_bib32
  article-title: Polyploidy in tissue repair and regeneration
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a040881
– volume: 60
  start-page: 151
  year: 1975
  ident: 10.1016/j.semcdb.2023.05.009_bib143
  article-title: DNA in human tumors: a cytophotometric study
  publication-title: Curr. Top. Pathol.
– volume: 14
  start-page: 111
  issue: 2
  year: 2008
  ident: 10.1016/j.semcdb.2023.05.009_bib88
  article-title: Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2008.07.002
– volume: 16
  start-page: 20
  issue: 1
  year: 2016
  ident: 10.1016/j.semcdb.2023.05.009_bib3
  article-title: DNA damage and the balance between survival and death in cancer biology
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc.2015.2
– volume: 8
  start-page: 1501
  issue: 10
  year: 2009
  ident: 10.1016/j.semcdb.2023.05.009_bib8
  article-title: Developmentally programmed endoreduplication in animals
  publication-title: Cell Cycle
  doi: 10.4161/cc.8.10.8325
– volume: 28
  start-page: 149
  issue: 1
  year: 2017
  ident: 10.1016/j.semcdb.2023.05.009_bib129
  article-title: Cyclin D mediates tolerance of genome-doubling in cancers with functional p53
  publication-title: Ann. Oncol.
  doi: 10.1093/annonc/mdw612
– volume: 25
  start-page: 2584
  issue: 11
  year: 2006
  ident: 10.1016/j.semcdb.2023.05.009_bib91
  article-title: Apoptosis regulation in tetraploid cancer cells
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7601127
– volume: 50
  start-page: 1189
  issue: 8
  year: 2018
  ident: 10.1016/j.semcdb.2023.05.009_bib96
  article-title: Genome doubling shapes the evolution and prognosis of advanced cancers
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0165-1
– volume: 141
  start-page: 81
  issue: 1
  year: 2010
  ident: 10.1016/j.semcdb.2023.05.009_bib114
  article-title: Persistent telomere damage induces bypass of mitosis and tetraploidy
  publication-title: Cell
  doi: 10.1016/j.cell.2010.01.031
– volume: 110
  start-page: 9621
  issue: 24
  year: 2013
  ident: 10.1016/j.semcdb.2023.05.009_bib6
  article-title: Making big cells: one size does not fit all
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1306908110
– volume: 90
  start-page: 671
  issue: 4
  year: 1997
  ident: 10.1016/j.semcdb.2023.05.009_bib13
  article-title: Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80528-0
– volume: 145
  issue: 14
  year: 2018
  ident: 10.1016/j.semcdb.2023.05.009_bib15
  article-title: Polyploidy in tissue homeostasis and regeneration
  publication-title: Development
  doi: 10.1242/dev.156034
– volume: 207
  start-page: 29
  issue: 1
  year: 2017
  ident: 10.1016/j.semcdb.2023.05.009_bib65
  article-title: DNA Replication Control During Drosophila Development: Insights Into The Onset Of S Phase, Replication Initiation, And Fork Progression
  publication-title: Genetics
  doi: 10.1534/genetics.115.186627
– volume: 27
  start-page: 585
  year: 2011
  ident: 10.1016/j.semcdb.2023.05.009_bib108
  article-title: The causes and consequences of polyploidy in normal development and cancer
  publication-title: Annu Rev. Cell Dev. Biol.
  doi: 10.1146/annurev-cellbio-092910-154234
– volume: 7
  year: 2018
  ident: 10.1016/j.semcdb.2023.05.009_bib30
  article-title: Fizzy-related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut
  publication-title: Elife
  doi: 10.7554/eLife.38327
– volume: 14
  start-page: 1
  issue: 1
  year: 1953
  ident: 10.1016/j.semcdb.2023.05.009_bib33
  article-title: Endomitotic reduplication mechanisms in ascites tumors of the mouse
  publication-title: J. Natl. Cancer Inst.
– volume: 1167
  start-page: 105
  year: 2019
  ident: 10.1016/j.semcdb.2023.05.009_bib42
  article-title: P53 and apoptosis in the drosophila model
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-3-030-23629-8_6
– volume: 27
  start-page: 2911
  issue: 19
  year: 2016
  ident: 10.1016/j.semcdb.2023.05.009_bib102
  article-title: Transient endoreplication down-regulates the kinesin-14 HSET and contributes to genomic instability
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.E16-03-0159
– volume: 144
  start-page: 27
  issue: 1
  year: 2011
  ident: 10.1016/j.semcdb.2023.05.009_bib105
  article-title: Massive genomic rearrangement acquired in a single catastrophic event during cancer development
  publication-title: Cell
  doi: 10.1016/j.cell.2010.11.055
– volume: 131
  start-page: 275
  issue: 2
  year: 2004
  ident: 10.1016/j.semcdb.2023.05.009_bib61
  article-title: Caspases function in autophagic programmed cell death in Drosophila
  publication-title: Development
  doi: 10.1242/dev.00933
– volume: 5
  year: 2016
  ident: 10.1016/j.semcdb.2023.05.009_bib140
  article-title: Distinct responses to reduplicated chromosomes require distinct Mad2 responses
  publication-title: Elife
  doi: 10.7554/eLife.15204
– volume: 3
  start-page: 1371
  issue: 8
  year: 1997
  ident: 10.1016/j.semcdb.2023.05.009_bib144
  article-title: Inhibition of radiation-induced G2 delay potentiates cell death by apoptosis and/or the induction of giant cells in colorectal tumor cells with disrupted p53 function
  publication-title: Clin. Cancer Res
– volume: 604
  start-page: 146
  issue: 7904
  year: 2022
  ident: 10.1016/j.semcdb.2023.05.009_bib136
  article-title: Genetic instability from a single S phase after whole-genome duplication
  publication-title: Nature
  doi: 10.1038/s41586-022-04578-4
– volume: 135
  start-page: 1451
  issue: 8
  year: 2008
  ident: 10.1016/j.semcdb.2023.05.009_bib19
  article-title: APC/CFzr/Cdh1 promotes cell cycle progression during the Drosophila endocycle
  publication-title: Development
  doi: 10.1242/dev.016295
– volume: 45
  start-page: 1134
  issue: 10
  year: 2013
  ident: 10.1016/j.semcdb.2023.05.009_bib97
  article-title: Pan-cancer patterns of somatic copy number alteration
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2760
– volume: 12
  start-page: 1315
  issue: 5
  year: 2001
  ident: 10.1016/j.semcdb.2023.05.009_bib83
  article-title: Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.12.5.1315
– volume: 35
  start-page: 6
  issue: 1
  year: 2019
  ident: 10.1016/j.semcdb.2023.05.009_bib74
  article-title: Solving the polyploid mystery in health and disease
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2018.10.005
– volume: 3
  start-page: 815
  year: 2012
  ident: 10.1016/j.semcdb.2023.05.009_bib153
  article-title: Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms1825
– volume: 430
  start-page: 757
  issue: 2
  year: 2013
  ident: 10.1016/j.semcdb.2023.05.009_bib21
  article-title: The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells
  publication-title: Biochem Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2012.11.075
– volume: 176
  start-page: 183
  issue: 2
  year: 2007
  ident: 10.1016/j.semcdb.2023.05.009_bib133
  article-title: Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200610099
– volume: 81
  start-page: 1
  year: 2022
  ident: 10.1016/j.semcdb.2023.05.009_bib38
  article-title: Polyploid giant cancer cells: an emerging new field of cancer biology
  publication-title: Semin Cancer Biol.
  doi: 10.1016/j.semcancer.2021.10.006
– volume: 148
  issue: 14
  year: 2021
  ident: 10.1016/j.semcdb.2023.05.009_bib9
  article-title: Polyploid cardiomyocytes: implications for heart regeneration
  publication-title: Development
  doi: 10.1242/dev.199401
– volume: 42
  start-page: 600
  issue: 6
  year: 2017
  ident: 10.1016/j.semcdb.2023.05.009_bib27
  article-title: Tension creates an endoreplication wavefront that leads regeneration of epicardial tissue
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2017.08.024
– volume: 29
  start-page: 3937
  issue: 22
  year: 2019
  ident: 10.1016/j.semcdb.2023.05.009_bib137
  article-title: Cell-cycle asynchrony generates DNA damage at mitotic entry in polyploid cells
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2019.09.041
– volume: 29
  start-page: 1005
  issue: 12
  year: 2005
  ident: 10.1016/j.semcdb.2023.05.009_bib150
  article-title: Segregation of genomes in polyploid tumour cells following mitotic catastrophe
  publication-title: Cell Biol. Int.
  doi: 10.1016/j.cellbi.2005.10.008
– volume: 62
  start-page: 7316
  issue: 24
  year: 2002
  ident: 10.1016/j.semcdb.2023.05.009_bib50
  article-title: Tissue-specific induction of p53 targets in vivo
  publication-title: Cancer Res.
– volume: 101
  start-page: 1469
  issue: 12
  year: 2016
  ident: 10.1016/j.semcdb.2023.05.009_bib56
  article-title: Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint
  publication-title: Haematologica
  doi: 10.3324/haematol.2016.149914
– volume: 52
  start-page: 68
  year: 2020
  ident: 10.1016/j.semcdb.2023.05.009_bib147
  article-title: Senescence in polyploid giant cancer cells: a road that leads to chemoresistance
  publication-title: Cytokine Growth Factor Rev.
  doi: 10.1016/j.cytogfr.2019.11.002
– volume: 44
  start-page: 433
  issue: 4
  year: 2018
  ident: 10.1016/j.semcdb.2023.05.009_bib36
  article-title: Myocardial polyploidization creates a barrier to heart regeneration in zebrafish
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2018.01.021
– volume: 4
  start-page: 175
  issue: 2
  year: 2014
  ident: 10.1016/j.semcdb.2023.05.009_bib107
  article-title: Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-13-0285
– volume: 27
  start-page: 1885
  issue: 12
  year: 2016
  ident: 10.1016/j.semcdb.2023.05.009_bib79
  article-title: Different cell cycle modifications repress apoptosis at different steps independent of developmental signaling in Drosophila
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e16-03-0139
– volume: 23
  start-page: 621
  issue: 10
  year: 1993
  ident: 10.1016/j.semcdb.2023.05.009_bib122
  article-title: Antimicrotubule agents induce polyploidization of human leukaemic cell lines with megakaryocytic features
  publication-title: Eur. J. Clin. Invest.
  doi: 10.1111/j.1365-2362.1993.tb00723.x
– volume: 482
  start-page: 53
  issue: 7383
  year: 2012
  ident: 10.1016/j.semcdb.2023.05.009_bib104
  article-title: DNA breaks and chromosome pulverization from errors in mitosis
  publication-title: Nature
  doi: 10.1038/nature10802
– volume: 31
  start-page: 707
  issue: 6
  year: 2020
  ident: 10.1016/j.semcdb.2023.05.009_bib54
  article-title: Megakaryocyte polyploidization: role in platelet production
  publication-title: Platelets
  doi: 10.1080/09537104.2019.1667497
– volume: 97
  start-page: 7301
  issue: 13
  year: 2000
  ident: 10.1016/j.semcdb.2023.05.009_bib41
  article-title: Identification and characterization of a p53 homologue in Drosophila melanogaster
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.97.13.7301
– volume: 9
  issue: 5
  year: 2014
  ident: 10.1016/j.semcdb.2023.05.009_bib53
  article-title: Cytoplasmic localization of p21 protects trophoblast giant cells from DNA damage induced apoptosis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0097434
– volume: 209
  start-page: 485
  issue: 4
  year: 2015
  ident: 10.1016/j.semcdb.2023.05.009_bib26
  article-title: The expanding implications of polyploidy
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201502016
– volume: 50
  start-page: 175
  issue: 2
  year: 1975
  ident: 10.1016/j.semcdb.2023.05.009_bib64
  article-title: Differential replication of satellite DNA in polyploid tissues of Drosophila virilis
  publication-title: Chromosoma
  doi: 10.1007/BF00283238
– volume: 2015
  year: 2015
  ident: 10.1016/j.semcdb.2023.05.009_bib85
  article-title: Targeting the mitotic catastrophe signaling pathway in cancer
  publication-title: Mediat. Inflamm.
  doi: 10.1155/2015/146282
– volume: 10
  issue: 5
  year: 2014
  ident: 10.1016/j.semcdb.2023.05.009_bib68
  article-title: Copy number variation is a fundamental aspect of the placental genome
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1004290
– volume: 158
  start-page: 833
  issue: 4
  year: 2014
  ident: 10.1016/j.semcdb.2023.05.009_bib90
  article-title: Cytokinesis failure triggers hippo tumor suppressor pathway activation
  publication-title: Cell
  doi: 10.1016/j.cell.2014.06.029
– volume: 24
  start-page: 2420
  issue: 21
  year: 2010
  ident: 10.1016/j.semcdb.2023.05.009_bib130
  article-title: The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1
  publication-title: Genes Dev.
  doi: 10.1101/gad.1954410
– volume: 18
  start-page: 1403
  issue: 9
  year: 2011
  ident: 10.1016/j.semcdb.2023.05.009_bib84
  article-title: Illicit survival of cancer cells during polyploidization and depolyploidization
  publication-title: Cell Death Differ.
  doi: 10.1038/cdd.2010.145
– volume: 56
  start-page: 1976
  issue: 13
  year: 2021
  ident: 10.1016/j.semcdb.2023.05.009_bib112
  article-title: Polyploid mitosis and depolyploidization promote chromosomal instability and tumor progression in a Notch-induced tumor model
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2021.05.017
– volume: 154
  start-page: 82
  year: 2018
  ident: 10.1016/j.semcdb.2023.05.009_bib39
  article-title: Regulation and function of p53: a perspective from Drosophila studies
  publication-title: Mech. Dev.
  doi: 10.1016/j.mod.2018.05.007
– volume: 178
  start-page: 85
  issue: 1
  year: 2007
  ident: 10.1016/j.semcdb.2023.05.009_bib59
  article-title: Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200703206
– volume: 41
  start-page: 42
  issue: 1
  year: 2021
  ident: 10.1016/j.semcdb.2023.05.009_bib69
  article-title: Differential roles for diploid and polyploid hepatocytes in acute and chronic liver injury
  publication-title: Semin Liver Dis.
  doi: 10.1055/s-0040-1719175
– volume: 460
  start-page: 278
  issue: 7252
  year: 2009
  ident: 10.1016/j.semcdb.2023.05.009_bib101
  article-title: A mechanism linking extra centrosomes to chromosomal instability
  publication-title: Nature
  doi: 10.1038/nature08136
– volume: 134
  start-page: 508
  issue: 3
  year: 2014
  ident: 10.1016/j.semcdb.2023.05.009_bib146
  article-title: Tumor stroma and differentiated cancer cells can be originated directly from polyploid giant cancer cells induced by paclitaxel
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.28319
– volume: 21
  start-page: 175
  issue: 2
  year: 2011
  ident: 10.1016/j.semcdb.2023.05.009_bib66
  article-title: Developmental control of the DNA replication and transcription programs
  publication-title: Genome Res
  doi: 10.1101/gr.114611.110
– volume: 124
  start-page: 3555
  issue: 18
  year: 1997
  ident: 10.1016/j.semcdb.2023.05.009_bib77
  article-title: Cell cycle progression, growth and patterning in imaginal discs despite inhibition of cell division after inactivation of Drosophila Cdc2 kinase
  publication-title: Development
  doi: 10.1242/dev.124.18.3555
– volume: 369
  start-page: 2014
  year: 1650
  ident: 10.1016/j.semcdb.2023.05.009_bib100
  article-title: Causes and consequences of centrosome abnormalities in cancer
  publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci.
– volume: 108
  start-page: 10004
  issue: 24
  year: 2011
  ident: 10.1016/j.semcdb.2023.05.009_bib155
  article-title: Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1103584108
– volume: 39
  start-page: 12
  year: 2015
  ident: 10.1016/j.semcdb.2023.05.009_bib4
  article-title: Cell death in development: Signaling pathways and core mechanisms
  publication-title: Semin Cell Dev. Biol.
  doi: 10.1016/j.semcdb.2015.02.001
– volume: 9
  year: 2020
  ident: 10.1016/j.semcdb.2023.05.009_bib81
  article-title: Polyploidy in the adult Drosophila brain
  publication-title: Elife
  doi: 10.7554/eLife.54385
– volume: 117
  start-page: 411
  issue: 5
  year: 2008
  ident: 10.1016/j.semcdb.2023.05.009_bib62
  article-title: Intercalary heterochromatin in polytene chromosomes of Drosophila melanogaster
  publication-title: Chromosoma
  doi: 10.1007/s00412-008-0163-7
– volume: 21
  start-page: 44
  issue: 1
  year: 2020
  ident: 10.1016/j.semcdb.2023.05.009_bib99
  article-title: Context is everything: aneuploidy in cancer
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/s41576-019-0171-x
– volume: 26
  start-page: 2971
  issue: 17
  year: 2015
  ident: 10.1016/j.semcdb.2023.05.009_bib119
  article-title: Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.E15-01-0003
– volume: 30
  start-page: 688
  issue: 9
  year: 2020
  ident: 10.1016/j.semcdb.2023.05.009_bib7
  article-title: Polyploidy: a biological force from cells to ecosystems
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2020.06.006
– volume: 206
  start-page: 37
  issue: 1–2
  year: 2013
  ident: 10.1016/j.semcdb.2023.05.009_bib121
  article-title: Change in HER2 (ERBB2) gene status after taxane-based chemotherapy for breast cancer: polyploidization can lead to diagnostic pitfalls with potential impact for clinical management
  publication-title: Cancer Genet.
  doi: 10.1016/j.cancergen.2012.12.001
– volume: 17
  start-page: 431
  issue: 5
  year: 2007
  ident: 10.1016/j.semcdb.2023.05.009_bib111
  article-title: A virus causes cancer by inducing massive chromosomal instability through cell fusion
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2007.01.049
– volume: 140
  start-page: 3
  issue: 1
  year: 2013
  ident: 10.1016/j.semcdb.2023.05.009_bib5
  article-title: Endoreplication and polyploidy: insights into development and disease
  publication-title: Development
  doi: 10.1242/dev.080531
– volume: 23
  start-page: 2224
  issue: 22
  year: 2013
  ident: 10.1016/j.semcdb.2023.05.009_bib28
  article-title: Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2013.09.029
– volume: 5
  start-page: 8907
  year: 2015
  ident: 10.1016/j.semcdb.2023.05.009_bib124
  article-title: p53 suppresses tetraploid development in mice
  publication-title: Sci. Rep.
  doi: 10.1038/srep08907
– volume: 26
  start-page: 239
  issue: 4
  year: 1972
  ident: 10.1016/j.semcdb.2023.05.009_bib1
  article-title: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.1972.33
– volume: 5
  issue: 1
  year: 2013
  ident: 10.1016/j.semcdb.2023.05.009_bib12
  article-title: Endoreplication
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a012948
– volume: 22
  start-page: 1690
  issue: 12
  year: 2008
  ident: 10.1016/j.semcdb.2023.05.009_bib18
  article-title: The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles
  publication-title: Genes Dev.
  doi: 10.1101/gad.469108
– volume: 8
  start-page: 3172
  issue: 19
  year: 2009
  ident: 10.1016/j.semcdb.2023.05.009_bib134
  article-title: The aurora B kinase inhibitor AZD1152 sensitizes cancer cells to fractionated irradiation and induces mitotic catastrophe
  publication-title: Cell Cycle
  doi: 10.4161/cc.8.19.9729
– volume: 437
  start-page: 1043
  issue: 7061
  year: 2005
  ident: 10.1016/j.semcdb.2023.05.009_bib98
  article-title: Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
  publication-title: Nature
  doi: 10.1038/nature04217
– volume: 27
  start-page: 4411
  issue: 32
  year: 2008
  ident: 10.1016/j.semcdb.2023.05.009_bib132
  article-title: Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug-induced polyploidy
  publication-title: Oncogene
  doi: 10.1038/onc.2008.77
– volume: 5
  start-page: 315
  issue: 4
  year: 2011
  ident: 10.1016/j.semcdb.2023.05.009_bib125
  article-title: p53: guardian of ploidy
  publication-title: Mol. Oncol.
  doi: 10.1016/j.molonc.2011.07.007
– volume: 21
  start-page: 765
  issue: 6
  year: 2012
  ident: 10.1016/j.semcdb.2023.05.009_bib103
  article-title: Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.03.044
– volume: 141
  start-page: 112
  issue: 1
  year: 2014
  ident: 10.1016/j.semcdb.2023.05.009_bib75
  article-title: Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability
  publication-title: Development
  doi: 10.1242/dev.098871
– volume: 30
  start-page: 639
  issue: 6
  year: 2016
  ident: 10.1016/j.semcdb.2023.05.009_bib31
  article-title: Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in Fan1 nuclease-defective knock-in mice
  publication-title: Genes Dev.
  doi: 10.1101/gad.276287.115
– volume: 608
  start-page: 795
  issue: 7924
  year: 2022
  ident: 10.1016/j.semcdb.2023.05.009_bib126
  article-title: Ordered and deterministic cancer genome evolution after p53 loss
  publication-title: Nature
  doi: 10.1038/s41586-022-05082-5
– volume: 24
  start-page: 635
  issue: 9
  year: 2000
  ident: 10.1016/j.semcdb.2023.05.009_bib151
  article-title: Release of mitotic descendants by giant cells from irradiated Burkitt's lymphoma cell line
  publication-title: Cell Biol. Int.
  doi: 10.1006/cbir.2000.0558
– volume: 17
  start-page: 91
  issue: 2
  year: 2008
  ident: 10.1016/j.semcdb.2023.05.009_bib60
  article-title: Genes and biological processes controlled by the Drosophila FOXA orthologue Fork head
  publication-title: Insect Mol. Biol.
  doi: 10.1111/j.1365-2583.2007.00785.x
– volume: 144
  start-page: 9
  issue: 1
  year: 2011
  ident: 10.1016/j.semcdb.2023.05.009_bib106
  article-title: Cancer genomes evolve by pulverizing single chromosomes
  publication-title: Cell
  doi: 10.1016/j.cell.2010.12.025
– volume: 69
  start-page: 2296
  issue: 6
  year: 2009
  ident: 10.1016/j.semcdb.2023.05.009_bib148
  article-title: Activation of meiosis-specific genes is associated with depolyploidization of human tumor cells following radiation-induced mitotic catastrophe
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-08-3364
– volume: 10
  start-page: 478
  issue: 7
  year: 2009
  ident: 10.1016/j.semcdb.2023.05.009_bib35
  article-title: Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm2718
– volume: 22
  start-page: 3158
  issue: 22
  year: 2008
  ident: 10.1016/j.semcdb.2023.05.009_bib45
  article-title: Endocycling cells do not apoptose in response to DNA rereplication genotoxic stress
  publication-title: Genes Dev.
  doi: 10.1101/gad.1710208
– volume: 25
  start-page: 486
  issue: 3
  year: 2018
  ident: 10.1016/j.semcdb.2023.05.009_bib2
  article-title: Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-017-0012-4
– volume: 33
  start-page: 124
  issue: 2
  year: 2011
  ident: 10.1016/j.semcdb.2023.05.009_bib14
  article-title: At the crossroads of differentiation and proliferation: precise control of cell-cycle changes by multiple signaling pathways in Drosophila follicle cells
  publication-title: Bioessays
  doi: 10.1002/bies.201000089
– volume: 122
  start-page: 2579
  issue: Pt 15
  year: 2009
  ident: 10.1016/j.semcdb.2023.05.009_bib89
  article-title: How do anti-mitotic drugs kill cancer cells?
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.039719
– volume: 50
  start-page: 710
  issue: 3
  year: 1990
  ident: 10.1016/j.semcdb.2023.05.009_bib123
  article-title: Development of polyploidization in taxol-resistant human leukemia cells in vitro
  publication-title: Cancer Res.
– volume: 32
  start-page: 1031
  issue: 9
  year: 2008
  ident: 10.1016/j.semcdb.2023.05.009_bib116
  article-title: Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy
  publication-title: Cell Biol. Int.
  doi: 10.1016/j.cellbi.2008.04.021
– volume: 28
  start-page: 1840
  issue: 16
  year: 2014
  ident: 10.1016/j.semcdb.2023.05.009_bib63
  article-title: Incomplete replication generates somatic DNA alterations within Drosophila polytene salivary gland cells
  publication-title: Genes Dev.
  doi: 10.1101/gad.245811.114
– volume: 182
  start-page: 423
  issue: 2
  year: 2009
  ident: 10.1016/j.semcdb.2023.05.009_bib44
  article-title: p53-independent apoptosis limits DNA damage-induced aneuploidy
  publication-title: Genetics
  doi: 10.1534/genetics.109.102327
– volume: 118
  issue: 7
  year: 2021
  ident: 10.1016/j.semcdb.2023.05.009_bib115
  article-title: Cancer recurrence and lethality are enabled by enhanced survival and reversible cell cycle arrest of polyaneuploid cells
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.2020838118
– volume: 121
  start-page: 1
  issue: Suppl 1
  year: 2008
  ident: 10.1016/j.semcdb.2023.05.009_bib34
  article-title: Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.025742
– volume: 25
  start-page: 29
  issue: 1
  year: 2004
  ident: 10.1016/j.semcdb.2023.05.009_bib52
  article-title: Differentiation of placental trophoblast giant cells requires downregulation of p53 and Rb
  publication-title: Placenta
  doi: 10.1016/S0143-4004(03)00215-7
– volume: 13
  issue: 9
  year: 2018
  ident: 10.1016/j.semcdb.2023.05.009_bib58
  article-title: Role of p53 and transcription-independent p53-induced apoptosis in shear-stimulated megakaryocytic maturation, particle generation, and platelet biogenesis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0203991
– volume: 381
  start-page: 713
  issue: 6584
  year: 1996
  ident: 10.1016/j.semcdb.2023.05.009_bib145
  article-title: Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
  publication-title: Nature
  doi: 10.1038/381713a0
– volume: 29
  start-page: 245
  issue: 3–4
  year: 2021
  ident: 10.1016/j.semcdb.2023.05.009_bib11
  article-title: Communal living: the role of polyploidy and syncytia in tissue biology
  publication-title: Chromosome Res.
  doi: 10.1007/s10577-021-09664-3
– volume: 24
  start-page: 2294
  issue: 20
  year: 2010
  ident: 10.1016/j.semcdb.2023.05.009_bib47
  article-title: Error-prone polyploid mitosis during normal Drosophila development
  publication-title: Genes Dev.
  doi: 10.1101/gad.1952710
– volume: 15
  issue: 7
  year: 2019
  ident: 10.1016/j.semcdb.2023.05.009_bib16
  article-title: A-Myb-MuvB-Aurora B network regulates the choice between mitotic cycles and polyploid endoreplication cycles
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1008253
– volume: 14
  start-page: 1181
  issue: 11
  year: 2012
  ident: 10.1016/j.semcdb.2023.05.009_bib25
  article-title: E2F8 is essential for polyploidization in mammalian cells
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2585
– volume: 186
  start-page: 528
  issue: 3
  year: 2023
  ident: 10.1016/j.semcdb.2023.05.009_bib127
  article-title: Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication
  publication-title: Cell
  doi: 10.1016/j.cell.2022.12.036
– volume: 22
  start-page: 3024
  issue: 21
  year: 2008
  ident: 10.1016/j.semcdb.2023.05.009_bib51
  article-title: Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity
  publication-title: Genes Dev.
  doi: 10.1101/gad.1718108
– volume: 33
  start-page: 116
  issue: 1
  year: 2014
  ident: 10.1016/j.semcdb.2023.05.009_bib152
  article-title: Generation of cancer stem-like cells through the formation of polyploid giant cancer cells
  publication-title: Oncogene
  doi: 10.1038/onc.2013.96
– volume: 101
  start-page: 91
  issue: 1
  year: 2000
  ident: 10.1016/j.semcdb.2023.05.009_bib40
  article-title: Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80626-1
– volume: 10
  issue: 9
  year: 2014
  ident: 10.1016/j.semcdb.2023.05.009_bib46
  article-title: Low Levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in drosophila endocycling cells
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1004581
– volume: 111
  start-page: 13409
  issue: 37
  year: 2014
  ident: 10.1016/j.semcdb.2023.05.009_bib72
  article-title: Single cell sequencing reveals low levels of aneuploidy across mammalian tissues
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1415287111
– volume: 26
  start-page: 34
  issue: 1
  year: 2020
  ident: 10.1016/j.semcdb.2023.05.009_bib71
  article-title: In vivo lineage tracing of polyploid hepatocytes reveals extensive proliferation during liver regeneration
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2019.11.014
– volume: 146
  issue: 15
  year: 2019
  ident: 10.1016/j.semcdb.2023.05.009_bib80
  article-title: Wound-induced polyploidization is driven by Myc and supports tissue repair in the presence of DNA damage
  publication-title: Development
  doi: 10.1242/dev.173005
– volume: 103
  start-page: 9952
  issue: 26
  year: 2006
  ident: 10.1016/j.semcdb.2023.05.009_bib43
  article-title: Ionizing radiation induces caspase-dependent but Chk2- and p53-independent cell death in Drosophila melanogaster
  publication-title: Proc. Natl. Acad. Sci. U. S. A
  doi: 10.1073/pnas.0510528103
– volume: 4
  issue: 3
  year: 2017
  ident: 10.1016/j.semcdb.2023.05.009_bib87
  article-title: Caspase 2 in mitotic catastrophe: The terminator of aneuploid and tetraploid cells
  publication-title: Mol. Cell Oncol.
SSID ssj0004926
Score 2.4813173
SecondaryResourceType review_article
Snippet One of the important functions of regulated cell death is to prevent cells from inappropriately acquiring extra copies of their genome, a state known as...
SourceID pubmedcentral
proquest
pubmed
crossref
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 35
SubjectTerms Aneuploidy
Apoptosis
Apoptosis - genetics
Chromosome Segregation
Endoreplication
Genomic Instability
Humans
Neoplasms - genetics
Polyploidy
Regulated cell death
Tetraploid
Title The antagonistic relationship between apoptosis and polyploidy in development and cancer
URI https://dx.doi.org/10.1016/j.semcdb.2023.05.009
https://www.ncbi.nlm.nih.gov/pubmed/37331841
https://www.proquest.com/docview/2827666381
https://pubmed.ncbi.nlm.nih.gov/PMC10724375
Volume 156
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9tAEF5MSqGX0nfdpGYLvSpeaV_KMZgG92VK24Bvy-5qVSs4kvDj4Et-e2b0cOq2EOhJSDOCZWY0D_TNDCHv81hbK20aKeE0FCjMR86zEOVcJ155l7ddaV9nanopPs3lfEAmfS8Mwio739_69MZbd0_GnTTHdVGMf8QsheweXS_GbDXHDnah0cpPb-5gHjgQrwXZiwi5-_a5BuO1Dtc-c6e4QryZ34mwxH-Hp7_Tzz9RlL-FpYsn5HGXT9Lz9shPySCUz8jDdsPk7jmZgxlQEJ79VZXNSGa66tFvi6KmHUqL2rqqN9W6WANvRutquauXVZHtaFHS7A5W1FA92snqBbm8-PBzMo26ZQqRF6nYRHnuOHPKQfwJiulE-Fjg1irLEptpFnudubOUq9TpXCqgBKGl48Jxbl1sGX9JjsqqDK8JdTJjXiWJ9WdSOMeshJowlZlOeLAhD0PCexka300ax4UXS9NDyq5MK3mDkjdMGpD8kET7t-p20sY9_LpXjzmwGAPB4J433_XaNPAx4R8SW4ZquzZQf2qo5yCLGZJXrXb3Z-G43TIVQEkP9L5nwEHdh5SyWDQDu2OUN9fyzX8f-Zg8gjuB4LdYnpCjzWob3kI2tHGjxtxH5MH55PuXb3j9-Hk6uwVN8A23
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VIgQXxJstLyPBMV0nfqUHDgiotvRxoZX2ZmzHaYO2SbTZCu2FP8UfZJzHlgWkSki9ZuzI-mYyD-XzDMCbPFbGCJNGkluFBQp1kXXURzlTiZPO5t2ttMMjOTnhn6diugE_h7swgVbZ-_7Op7feun8y7tEc10Ux_hLTFLP74HpDzJbTnlm575ffsW5r3u19RCW_TZLdT8cfJlE_WiByPOWLKM8to1Za9MZeUpVwF_Mww8nQxGSKxk5ldidlMrUqFxIlnithGbeMGRsbyvC9N-AmR3cRxiZs_7jklYQOfB2rn0fheMN9vZZU1vhzl9ntMLO8bRgaeJD_jod_57t_0jZ_i4O79-Bun8CS9x1G92HDlw_gVjfScvkQpmh3BLVlTquy7QFN5gPd7qyoSU8LI6au6kXVFA2uzUhdzZb1rCqyJSlKkl3ymFqpC4Y5fwQn1wLxY9gsq9I_BWJFRp1MEuN2BLeWGoFFaCoylTBvfO5HwAYMtetbm4cJGzM9cNi-6Q55HZDXVGhEfgTRalfdtfa4Yr0a1KPXTFRj9Lli5-tBmxq_3vBLxpS-umg0FrwKC0hMm0bwpNPu6iwsjNNMOUrSNb2vFoTO4OuSsjhrO4THAW-mxNZ_H_kV3J4cHx7og72j_WdwByU8MO9i8Rw2F_ML_wJTsYV92Zo-ga_X_a39AquyRkA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+antagonistic+relationship+between+apoptosis+and+polyploidy+in+development+and+cancer&rft.jtitle=Seminars+in+cell+%26+developmental+biology&rft.au=Herriage%2C+Hunter+C.&rft.au=Huang%2C+Yi-Ting&rft.au=Calvi%2C+Brian+R.&rft.date=2024-03-15&rft.issn=1084-9521&rft.eissn=1096-3634&rft.volume=156&rft.spage=35&rft.epage=43&rft_id=info:doi/10.1016%2Fj.semcdb.2023.05.009&rft_id=info%3Apmid%2F37331841&rft.externalDocID=PMC10724375
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1084-9521&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1084-9521&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1084-9521&client=summon