"Leaky Gut" as a Keystone of the Connection between Depression and Obstructive Sleep Apnea Syndrome? A Rationale and Study Design

• Published in: Metabolites Vol. 12; no. 2; p. 152
• Main Authors: Gawlik-Kotelnicka, Oliwia, Margulska, Aleksandra, Gabryelska, Agata, Sochal, Marcin, Białasiewicz, Piotr, Strzelecki, Dominik
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.02.2022; MDPI
• Subjects: Antioxidants; Apnea; Biomarkers; Body mass index; Comorbidity; depression; Enzyme-linked immunosorbent assay; Fatty acids; Inflammation; Interleukin 6; intestinal permeability; Intestine; Malondialdehyde; Mental depression; Microbiota; Obesity; obstructive sleep apnea; Oxidative stress; Patients; Permeability; Population studies; Probiotics; Sleep; Sleep apnea; Sleep disorders; Study Protocol; Therapeutic applications; Transplantation; Tumor necrosis factor; Tumors; obstructive sleep apnea; intestinal permeability; depression; inflammation; oxidative stress

Obstructive sleep apnea (OSA) and depression are highly comorbid. Immune alterations, oxidative stress or microbiota dysfunction have been proposed as some mechanisms underlying this association. The aim of the proposed study is to assess the severity and profile of OSA and depressive symptoms in th...