Stearic, Oleic, and Linoleic Acids Have Comparable Effects on Markers of Thrombotic Tendency in Healthy Human Subjects

• Published in: The Journal of nutrition Vol. 135; no. 12; pp. 2805 - 2811
• Main Authors: Thijssen, Myriam A.M.A, Hornstra, Gerard, Mensink, Ronald P
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Nutritional Sciences 01.12.2005
• Subjects: Adenosine Diphosphate; Adenosine Diphosphate - pharmacology; Adult; adults; Aged; alpha-Linolenic Acid; alpha-Linolenic Acid - blood; Biological and medical sciences; biomarkers; Biomarkers - blood; blood; blood chemistry; blood coagulation; classification; Collagen; Collagen - pharmacology; Cross-Over Studies; diet; Disease Susceptibility; drug effects; epidemiology; Fatty Acids; Fatty Acids - blood; Feeding. Feeding behavior; Female; fibrinolysis; Fundamental and applied biological sciences. Psychology; hematology; Humans; linoleic acid; Male; men; Middle Aged; oleic acid; Oleic Acid - blood; pharmacology; Phospholipids; Phospholipids - blood; physiology; platelet aggregation; Platelet Aggregation - drug effects; Platelet Aggregation - physiology; Reference Values; Sex Characteristics; stearic acid; Stearic Acids; Stearic Acids - blood; thrombosis; Thrombosis - classification; Thrombosis - epidemiology; Vertebrates: anatomy and physiology, studies on body, several organs or systems; women; Human; Healthy subject; Nutrition; Coagulation; Polyunsaturated fatty acid; Cardiovascular disease; Lipids; fatty acids •thrombotic tendency •platelet aggregation •coagulation•fibrinolysis; Fatty acids; Fibrinolysis; Thrombosis; Linoleic acid; Vascular disease; Aggregation; n-6 fatty acid; Unsaturated fatty acid

Because human studies concerning the effects of stearic acid on thrombotic tendency are inconsistent, we compared the effects of stearic acid with those of its unsaturated derivatives, oleic acid and linoleic acid. In this randomized, crossover study, 45 subjects (27 women and 18 men) consumed, in r...