Hepatic heat shock and acute-phase gene expression are induced simultaneously after celiotomy in the anesthetized pig

• Published in: Anesthesiology (Philadelphia) Vol. 83; no. 4; pp. 850 - 859
• Main Authors: PANNEN, B. H. J, MAEDA, K, AYUSE, T, BRIENZA, N, REVELLY, J.-P, ROBOTHAM, J. L, BUCHMAN, T. G
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01.10.1995
• Subjects: Abdomen - surgery; Acute-Phase Proteins - genetics; Alpha-Globulins - genetics; Anesthesia; Anesthesia, General; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Biological and medical sciences; Female; Gene Expression Regulation; General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation; Heat-Shock Proteins - analysis; Heat-Shock Proteins - genetics; HSP72 Heat-Shock Proteins; Liver - metabolism; Medical sciences; RNA, Messenger - analysis; Swine; Trypsin Inhibitors - genetics; Liver; General anesthesia; Gene expression; Stress; Pig; Vertebrata; Mammalia; Animal; Surgery; Heat shock protein; Complication; Artiodactyla; Ungulata

The liver plays a central role in the whole organism's response to injury. Expression of hepatic acute-phase and heat-shock genes likely contributes to the restoration of homeostasis after stressful events. However, after prolonged ischemia, hepatic transcription of heat-shock genes can exclude...