Neurons Regulate Extracellular Levels of Amyloid beta -Protein via Proteolysis by Insulin-Degrading Enzyme

• Published in: The Journal of neuroscience Vol. 20; no. 5; pp. 1657 - 1665
• Main Authors: Vekrellis, Konstantinos, Ye, Zhen, Qiu, Wei Qiao, Walsh, Dominic, Hartley, Dean, Chesneau, Valerie, Rosner, Marsha Rich, Selkoe, Dennis J
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 01.03.2000; Society for Neuroscience
• Subjects: Alzheimer Disease - metabolism; Amyloid beta-Peptides - metabolism; Amyloid beta-Peptides - secretion; Animals; Biotin; Cerebral Cortex - cytology; Cytosol - metabolism; Extracellular Space - metabolism; Gene Expression Regulation, Enzymologic; Glucagon - pharmacology; Hypoglycemic Agents - pharmacology; Insulin - pharmacology; insulin-degrading enzyme; Insulysin - genetics; Insulysin - metabolism; Membrane Proteins - metabolism; Neurons - cytology; Neurons - drug effects; Neurons - enzymology; PC12 Cells; Protein Synthesis Inhibitors - pharmacology; Rats

Progressive cerebral accumulation of amyloid β-protein (Aβ) is an early and invariant feature of Alzheimer's disease. Little is known about how Aβ, after being secreted, is degraded and cleared from the extracellular space of the brain. Defective Aβ degradation could be a risk factor for the de...