Antcins from Antrodia cinnamomea and Antrodia salmonea Inhibit Angiotensin-Converting Enzyme 2 (ACE2) in Epithelial Cells: Can Be Potential Candidates for the Development of SARS-CoV-2 Prophylactic Agents
Antcins are newly identified steroid-like compounds from Taiwan's endemic medicinal mushrooms and . Scientific studies of the past two decades confirmed that antcins have various pharmacological activities, including potent anti-oxidant and anti-inflammatory effects. The severe acute respirator...
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Published in | Plants (Basel) Vol. 10; no. 8; p. 1736 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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23.08.2021
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Abstract | Antcins are newly identified steroid-like compounds from Taiwan's endemic medicinal mushrooms
and
. Scientific studies of the past two decades confirmed that antcins have various pharmacological activities, including potent anti-oxidant and anti-inflammatory effects. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the coronavirus disease-2019 (COVID-19) pandemic and is characterized as a significant threat to global public health. It was recently identified that SARS-CoV-2 required angiotensin converting enzyme 2 (ACE2), a receptor which supports host cell entry and disease onset. Here, we report a novel function of antcins, in which antcins exhibit inhibitory effects on ACE2. Compared to the untreated control group, treatment with various antcins (antcin-A, antcin-B, antcin-C, antcin-H, antcin-I, and antcin-M) significantly inhibited ACE2 activity in cultured human epithelial cells. Indeed, among the investigated antcins, antcin-A, antcin-B, antcin-C, and antcin-I showed a pronounceable inhibition against ACE2. These findings suggest that antcins could be novel anti-ACE2 agents to prevent SARS-CoV-2 host cell entry and the following disease onset. |
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AbstractList | Antcins are newly identified steroid-like compounds from Taiwan’s endemic medicinal mushrooms Antrodia cinnamomea and Antrodia salmonea. Scientific studies of the past two decades confirmed that antcins have various pharmacological activities, including potent anti-oxidant and anti-inflammatory effects. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the coronavirus disease-2019 (COVID-19) pandemic and is characterized as a significant threat to global public health. It was recently identified that SARS-CoV-2 required angiotensin converting enzyme 2 (ACE2), a receptor which supports host cell entry and disease onset. Here, we report a novel function of antcins, in which antcins exhibit inhibitory effects on ACE2. Compared to the untreated control group, treatment with various antcins (antcin-A, antcin-B, antcin-C, antcin-H, antcin-I, and antcin-M) significantly inhibited ACE2 activity in cultured human epithelial cells. Indeed, among the investigated antcins, antcin-A, antcin-B, antcin-C, and antcin-I showed a pronounceable inhibition against ACE2. These findings suggest that antcins could be novel anti-ACE2 agents to prevent SARS-CoV-2 host cell entry and the following disease onset. Antcins are newly identified steroid-like compounds from Taiwan’s endemic medicinal mushrooms Antrodia cinnamomea and Antrodia salmonea . Scientific studies of the past two decades confirmed that antcins have various pharmacological activities, including potent anti-oxidant and anti-inflammatory effects. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the coronavirus disease-2019 (COVID-19) pandemic and is characterized as a significant threat to global public health. It was recently identified that SARS-CoV-2 required angiotensin converting enzyme 2 (ACE2), a receptor which supports host cell entry and disease onset. Here, we report a novel function of antcins, in which antcins exhibit inhibitory effects on ACE2. Compared to the untreated control group, treatment with various antcins (antcin-A, antcin-B, antcin-C, antcin-H, antcin-I, and antcin-M) significantly inhibited ACE2 activity in cultured human epithelial cells. Indeed, among the investigated antcins, antcin-A, antcin-B, antcin-C, and antcin-I showed a pronounceable inhibition against ACE2. These findings suggest that antcins could be novel anti-ACE2 agents to prevent SARS-CoV-2 host cell entry and the following disease onset. Antcins are newly identified steroid-like compounds from Taiwan's endemic medicinal mushrooms and . Scientific studies of the past two decades confirmed that antcins have various pharmacological activities, including potent anti-oxidant and anti-inflammatory effects. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the coronavirus disease-2019 (COVID-19) pandemic and is characterized as a significant threat to global public health. It was recently identified that SARS-CoV-2 required angiotensin converting enzyme 2 (ACE2), a receptor which supports host cell entry and disease onset. Here, we report a novel function of antcins, in which antcins exhibit inhibitory effects on ACE2. Compared to the untreated control group, treatment with various antcins (antcin-A, antcin-B, antcin-C, antcin-H, antcin-I, and antcin-M) significantly inhibited ACE2 activity in cultured human epithelial cells. Indeed, among the investigated antcins, antcin-A, antcin-B, antcin-C, and antcin-I showed a pronounceable inhibition against ACE2. These findings suggest that antcins could be novel anti-ACE2 agents to prevent SARS-CoV-2 host cell entry and the following disease onset. |
Author | Gokila Vani, M Lin, Chin-Chung Wang, Sheng-Yang Hsieh, Han-Wen Senthil Kumar, K J |
AuthorAffiliation | 1 Bachelor Program of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan; zenkumar@dragon.nchu.edu.tw 2 Department of Forestry, National Chung Hsing University, Taichung 402, Taiwan; mgvani2009@gmail.com 3 Taiwan Leader Biotech Company, Taipei 103, Taiwan; ck_hsieh@twleaderlife.com (H.-W.H.); johnson@twleaderlifw.com (C.-C.L.) 4 Agricultural Biotechnology Research Center, Academia Sinica, Taipei 11529, Taiwan |
AuthorAffiliation_xml | – name: 4 Agricultural Biotechnology Research Center, Academia Sinica, Taipei 11529, Taiwan – name: 1 Bachelor Program of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan; zenkumar@dragon.nchu.edu.tw – name: 3 Taiwan Leader Biotech Company, Taipei 103, Taiwan; ck_hsieh@twleaderlife.com (H.-W.H.); johnson@twleaderlifw.com (C.-C.L.) – name: 2 Department of Forestry, National Chung Hsing University, Taichung 402, Taiwan; mgvani2009@gmail.com |
Author_xml | – sequence: 1 givenname: K J orcidid: 0000-0002-8310-0546 surname: Senthil Kumar fullname: Senthil Kumar, K J organization: Bachelor Program of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan – sequence: 2 givenname: M surname: Gokila Vani fullname: Gokila Vani, M organization: Department of Forestry, National Chung Hsing University, Taichung 402, Taiwan – sequence: 3 givenname: Han-Wen surname: Hsieh fullname: Hsieh, Han-Wen organization: Taiwan Leader Biotech Company, Taipei 103, Taiwan – sequence: 4 givenname: Chin-Chung surname: Lin fullname: Lin, Chin-Chung organization: Taiwan Leader Biotech Company, Taipei 103, Taiwan – sequence: 5 givenname: Sheng-Yang orcidid: 0000-0002-8579-3569 surname: Wang fullname: Wang, Sheng-Yang organization: Agricultural Biotechnology Research Center, Academia Sinica, Taipei 11529, Taiwan |
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Keywords | COVID-19 ACE2 SARS-CoV-2 antcin Antrodia cinnamomea Antrodia salmonea |
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Snippet | Antcins are newly identified steroid-like compounds from Taiwan's endemic medicinal mushrooms
and
. Scientific studies of the past two decades confirmed that... Antcins are newly identified steroid-like compounds from Taiwan’s endemic medicinal mushrooms Antrodia cinnamomea and Antrodia salmonea. Scientific studies of... Antcins are newly identified steroid-like compounds from Taiwan's endemic medicinal mushrooms Antrodia cinnamomea and Antrodia salmonea. Scientific studies of... Antcins are newly identified steroid-like compounds from Taiwan’s endemic medicinal mushrooms Antrodia cinnamomea and Antrodia salmonea . Scientific studies of... |
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StartPage | 1736 |
SubjectTerms | ACE2 Angiotensin Angiotensin-converting enzyme 2 antcin Antioxidants Antrodia cinnamomea Antrodia salmonea Brief Report Colon Conversion Coronaviruses COVID-19 COVID-19 vaccines Cytotoxicity Diabetes Disease prevention Disease transmission Drug dosages Enzymes Epithelial cells Epithelium Glycoproteins Infections Inflammation Investigations Oxidants Oxidizing agents Pandemics Peptidyl-dipeptidase A Proteins Public health Respiratory diseases RNA polymerase SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Steroids Viral diseases Viral infections |
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Title | Antcins from Antrodia cinnamomea and Antrodia salmonea Inhibit Angiotensin-Converting Enzyme 2 (ACE2) in Epithelial Cells: Can Be Potential Candidates for the Development of SARS-CoV-2 Prophylactic Agents |
URI | https://www.ncbi.nlm.nih.gov/pubmed/34451782 https://www.proquest.com/docview/2565518910/abstract/ https://search.proquest.com/docview/2566045661 https://pubmed.ncbi.nlm.nih.gov/PMC8399673 https://doaj.org/article/302ee522506449fc8fc773b5c2e78468 |
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