Towards Reference Values for Malondialdehyde on Exhaled Breath Condensate: A Systematic Literature Review and Meta-Analysis
Many pathological conditions and certain airway exposures are associated with oxidative stress (OS). Malondialdehyde (MDA) is an end-product of the oxidation of lipids in our cells and is present in all biological matrices including exhaled breath condensate (EBC). To use MDA as a biomarker of OS in...
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| Published in | Toxics (Basel) Vol. 10; no. 5; p. 258 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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18.05.2022
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| Abstract | Many pathological conditions and certain airway exposures are associated with oxidative stress (OS). Malondialdehyde (MDA) is an end-product of the oxidation of lipids in our cells and is present in all biological matrices including exhaled breath condensate (EBC). To use MDA as a biomarker of OS in EBC, a reference interval should be defined. Thus, we sought to summarize reference values reported in healthy adult populations by performing a systematic review and meta-analysis using a standardized protocol registered in PROSPERO (CRD42020146623). Articles were retrieved from four major databases and 25 studies with 28 subgroups were included. Defining the distribution of MDA measured in reference populations with a detection combined with a separation technique still represents a challenge due to the low number of studies available, different analytical methods used, and questionable methodological qualities of many studies. The most salient methodological drawbacks have been in data collection and reporting of methods and study results by the researchers. The lack of compliance with the recommendations of the European Respiratory Society and American Thoracic Society was the major limitation in the current research involving EBC. Consequently, we were unable to establish a reference interval for MDA in EBC. |
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| AbstractList | Many pathological conditions and certain airway exposures are associated with oxidative stress (OS). Malondialdehyde (MDA) is an end-product of the oxidation of lipids in our cells and is present in all biological matrices including exhaled breath condensate (EBC). To use MDA as a biomarker of OS in EBC, a reference interval should be defined. Thus, we sought to summarize reference values reported in healthy adult populations by performing a systematic review and meta-analysis using a standardized protocol registered in PROSPERO (CRD42020146623). Articles were retrieved from four major databases and 25 studies with 28 subgroups were included. Defining the distribution of MDA measured in reference populations with a detection combined with a separation technique still represents a challenge due to the low number of studies available, different analytical methods used, and questionable methodological qualities of many studies. The most salient methodological drawbacks have been in data collection and reporting of methods and study results by the researchers. The lack of compliance with the recommendations of the European Respiratory Society and American Thoracic Society was the major limitation in the current research involving EBC. Consequently, we were unable to establish a reference interval for MDA in EBC. Many pathological conditions and certain airway exposures are associated with oxidative stress (OS). Malondialdehyde (MDA) is an end-product of the oxidation of lipids in our cells and is present in all biological matrices including exhaled breath condensate (EBC). To use MDA as a biomarker of OS in EBC, a reference interval should be defined. Thus, we sought to summarize reference values reported in healthy adult populations by performing a systematic review and meta-analysis using a standardized protocol registered in PROSPERO (CRD42020146623). Articles were retrieved from four major databases and 25 studies with 28 subgroups were included. Defining the distribution of MDA measured in reference populations with a detection combined with a separation technique still represents a challenge due to the low number of studies available, different analytical methods used, and questionable methodological qualities of many studies. The most salient methodological drawbacks have been in data collection and reporting of methods and study results by the researchers. The lack of compliance with the recommendations of the European Respiratory Society and American Thoracic Society was the major limitation in the current research involving EBC. Consequently, we were unable to establish a reference interval for MDA in EBC.Many pathological conditions and certain airway exposures are associated with oxidative stress (OS). Malondialdehyde (MDA) is an end-product of the oxidation of lipids in our cells and is present in all biological matrices including exhaled breath condensate (EBC). To use MDA as a biomarker of OS in EBC, a reference interval should be defined. Thus, we sought to summarize reference values reported in healthy adult populations by performing a systematic review and meta-analysis using a standardized protocol registered in PROSPERO (CRD42020146623). Articles were retrieved from four major databases and 25 studies with 28 subgroups were included. Defining the distribution of MDA measured in reference populations with a detection combined with a separation technique still represents a challenge due to the low number of studies available, different analytical methods used, and questionable methodological qualities of many studies. The most salient methodological drawbacks have been in data collection and reporting of methods and study results by the researchers. The lack of compliance with the recommendations of the European Respiratory Society and American Thoracic Society was the major limitation in the current research involving EBC. Consequently, we were unable to establish a reference interval for MDA in EBC. |
| Author | Turcu, Veronica Hopf, Nancy B. Wild, Pascal Bergamaschi, Enrico Sauvain, Jean-Jacques Hemmendinger, Maud Canu, Irina Guseva |
| AuthorAffiliation | 2 Department of Public Health and Pediatrics, University of Turin, Via Zuretti 29, 10125 Turin, Italy; enrico.bergamaschi@unito.it 1 Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Epalinges, Switzerland; veronica.turcu@unisante.ch (V.T.); pascal.wild@unisante.ch (P.W.); maud.hemmindinger@unisante.ch (M.H.); jean-jacques.sauvain@unisante.ch (J.-J.S.); nancy.hopf@unisante.ch (N.B.H.) |
| AuthorAffiliation_xml | – name: 1 Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Epalinges, Switzerland; veronica.turcu@unisante.ch (V.T.); pascal.wild@unisante.ch (P.W.); maud.hemmindinger@unisante.ch (M.H.); jean-jacques.sauvain@unisante.ch (J.-J.S.); nancy.hopf@unisante.ch (N.B.H.) – name: 2 Department of Public Health and Pediatrics, University of Turin, Via Zuretti 29, 10125 Turin, Italy; enrico.bergamaschi@unito.it |
| Author_xml | – sequence: 1 givenname: Veronica surname: Turcu fullname: Turcu, Veronica – sequence: 2 givenname: Pascal surname: Wild fullname: Wild, Pascal – sequence: 3 givenname: Maud orcidid: 0000-0002-3702-1054 surname: Hemmendinger fullname: Hemmendinger, Maud – sequence: 4 givenname: Jean-Jacques surname: Sauvain fullname: Sauvain, Jean-Jacques – sequence: 5 givenname: Enrico surname: Bergamaschi fullname: Bergamaschi, Enrico – sequence: 6 givenname: Nancy B. orcidid: 0000-0002-4490-6109 surname: Hopf fullname: Hopf, Nancy B. – sequence: 7 givenname: Irina Guseva orcidid: 0000-0001-7059-8421 surname: Canu fullname: Canu, Irina Guseva |
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