CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates

• Published in: Journal of neurovirology Vol. 17; no. 1; pp. 82 - 91
• Main Authors: Gray, Lachlan R., Gabuzda, Dana, Cowley, Daniel, Ellett, Anne, Chiavaroli, Lisa, Wesselingh, Steven L., Churchill, Melissa J., Gorry, Paul R.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.02.2011
• Subjects: AIDS Dementia Complex - genetics; AIDS Dementia Complex - metabolism; AIDS Dementia Complex - virology; Alleles; Amino Acid Sequence; Biomedical and Life Sciences; Biomedicine; Brain - metabolism; Brain - virology; CD4 Antigens - metabolism; Cell Line; Central Nervous System - metabolism; Central Nervous System - virology; Down-Regulation; Genes, MHC Class I; Genes, nef; HIV Infections - genetics; HIV Infections - metabolism; HIV Infections - virology; HIV-1 - genetics; HIV-1 - pathogenicity; Human immunodeficiency virus 1; Humans; Immunology; Infectious Diseases; Lymphoid Tissue - metabolism; Lymphoid Tissue - virology; Male; Molecular Sequence Data; nef Gene Products, Human Immunodeficiency Virus - genetics; nef Gene Products, Human Immunodeficiency Virus - metabolism; nef Gene Products, Human Immunodeficiency Virus - physiology; Neurology; Neurosciences; Phylogeny; Virology; Virus Replication; HIV-1; CD4; MHC-1; Lymphoid; CNS; Neurotropism; Nef; Dementia

Human immunodeficiency virus type 1 (HIV-1) nef undergoes adaptive evolution in the central nervous system (CNS), reflecting altered requirements for HIV-1 replication in macrophages/microglia and brain-specific immune selection pressures. The role of Nef in HIV-1 neurotropism and pathogenesis of HI...