Neutralizing Concentrations of Anti-Botulinum Toxin Antibodies Positively Correlate with Mouse Neutralization Assay Results in a Guinea Pig Model

• Published in: Toxins Vol. 13; no. 9; p. 671
• Main Authors: Tomic, Milan T, Farr-Jones, Shauna, Syar, Emily S, Niemuth, Nancy, Kobs, Dean, Hackett, Michael J, Espinoza, Yero, Martinez, Zacchary, Pham, Khanh, Snow, Doris M, Marks, James D, Cobb, Ronald R
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.09.2021; MDPI
• Subjects: aerosol; Animals; Antibodies; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - therapeutic use; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - therapeutic use; Antitoxins; Antitoxins - immunology; Antitoxins - therapeutic use; botulinum neurotoxin; Botulinum toxin; Botulinum toxin type A; Botulinum toxin type B; Botulinum Toxins - toxicity; Botulism; Botulism - drug therapy; Clostridium botulinum - genetics; Disease Models, Animal; Drug Combinations; Estimates; Exposure; Food contamination; guinea pig inhalation model; Guinea Pigs; Inhalation; Injection; Intravenous administration; Mice; Monoclonal antibodies; monoclonal antibody (mAb); Neurotoxins; Neutralization; Neutralizing; oligoclonal antibody; Pharmacokinetics; Prophylaxis; Respiration; Respiratory failure; Serogroup; Swine; Toxins; United States > US; guinea pig inhalation model; botulism; botulinum neurotoxin; monoclonal antibody (mAb); mouse neutralization assay (MNA); oligoclonal antibody; aerosol; neutralizing antibody concentration (NAC)

Botulinum neurotoxins (BoNT) are some of the most toxic proteins known and can induce respiratory failure requiring long-term intensive care. Treatment of botulism includes the administration of antitoxins. Monoclonal antibodies (mAbs) hold considerable promise as BoNT therapeutics and prophylactics...