Postprandial Mineral Metabolism and Secondary Hyperparathyroidism in Early CKD

• Published in: Journal of the American Society of Nephrology Vol. 19; no. 3; pp. 615 - 623
• Main Authors: Isakova, Tamara, Gutierrez, Orlando, Shah, Anand, Castaldo, Lorraine, Holmes, Julie, Lee, Hang, Wolf, Myles
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.03.2008; American Society of Nephrology
• Subjects: Adult; Aged; Biological and medical sciences; Calcium - blood; Case-Control Studies; Clinical Research; Endocrinopathies; Female; Fibroblast Growth Factors - blood; Humans; Hyperparathyroidism, Secondary - blood; Hyperparathyroidism, Secondary - etiology; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - complications; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Parathyroid Hormone - blood; Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases); Phosphorus - blood; Postprandial Period - physiology; Endocrinopathy; Nephrology; Parathyroid diseases; Postprandial; Early; Minerals; Secondary metabolism; Hyperparathyroidism; Urology

Normophosphatemia and normocalcemia are maintained in chronic kidney disease (CKD) by increased levels of fibroblast growth factor-23 (FGF-23) and parathyroid hormone (PTH), but the stimuli for secretion of these hormones in early CKD are incompletely understood. Most human physiologic studies have...