Mitochondrial Fission Governed by Drp1 Regulates Exogenous Fatty Acid Usage and Storage in Hela Cells

• Published in: Metabolites Vol. 11; no. 5; p. 322
• Main Authors: Song, Jae-Eun, Alves, Tiago C., Stutz, Bernardo, Šestan-Peša, Matija, Kilian, Nicole, Jin, Sungho, Diano, Sabrina, Kibbey, Richard G., Horvath, Tamas L.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.05.2021; MDPI
• Subjects: Bioenergetics; Carnitine palmitoyltransferase; Cell cycle; Cytology; Dynamin; fatty acid oxidation; Fatty acids; Glucose; Homeostasis; Kinases; lipid homeostasis; Lipids; Metabolism; Mitochondria; mitochondrial dynamics; Morphology; Oxidation; Palmitoyltransferase; Proteins; Respiration; lipid homeostasis; fatty acid oxidation; mitochondrial dynamics

In the presence of high abundance of exogenous fatty acids, cells either store fatty acids in lipid droplets or oxidize them in mitochondria. In this study, we aimed to explore a novel and direct role of mitochondrial fission in lipid homeostasis in HeLa cells. We observed the association between mi...