Some polybrominated diphenyl ether (PBDE) flame retardants with wide environmental distribution inhibit TCDD-induced EROD activity in primary cultured carp ( Cyprinus carpio) hepatocytes

• Published in: Aquatic toxicology Vol. 68; no. 2; pp. 129 - 139
• Main Authors: Kuiper, R.V, Bergman, Å, Vos, J.G, van den Berg, M
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 10.06.2004; Elsevier Science
• Subjects: Agnatha. Pisces; Analysis of Variance; Animal, plant and microbial ecology; Animals; Applied ecology; BFRs; Biological and medical sciences; Biomarkers; Carp hep; Carps - metabolism; Cyprinus carpio; Cytochrome P-450 CYP1A1 - biosynthesis; Ecotoxicology, biological effects of pollution; Effects of pollution and side effects of pesticides on vertebrates; Enzyme Induction - drug effects; EROD; EROD inhibition; Flame Retardants - toxicity; Freshwater; Fundamental and applied biological sciences. Psychology; Halogenated Diphenyl Ethers; Hepatocytes - metabolism; Hydrocarbons, Brominated - toxicity; In vitro; Male; PBDE; Phenyl Ethers - toxicity; Polybrominated Biphenyls; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Time Factors; Carp hep; EROD; BFRs; EROD inhibition; In vitro; PBDE; Ecotoxicology; Ether; Digestive system; Toxicity; Liver; Enzyme inhibitor; Flame retardant; Freshwater environment; Aquatic environment; Vertebrata; Hepatocyte; Pisces; Bromine Organic compounds; Cyprinus carpio; Cyprinidae; Organic compounds

Ethoxyresorufin- O-deethylase (EROD) activity, a catalytic function of the cytochrome P450 1A (CYP1A) microsomal oxygenase subfamily, is a popular biomarker for exposure to xenobiotics, polyhalogenated aromatic hydrocarbons (PHAHs) in particular. It has found wide use in aquatic pollution assessment...