EPA and DHA differentially modulate monocyte inflammatory response in subjects with chronic inflammation in part via plasma specialized pro-resolving lipid mediators: A randomized, double-blind, crossover study

• Published in: Atherosclerosis Vol. 316; pp. 90 - 98
• Main Authors: So, Jisun, Wu, Dayong, Lichtenstein, Alice H., Tai, Albert K., Matthan, Nirupa R., Maddipati, Krishna Rao, Lamon-Fava, Stefania
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.01.2021
• Subjects: atherosclerosis; Cross-Over Studies; DHA; Dietary Supplements; docosahexaenoic acid; Docosahexaenoic Acids; Double-Blind Method; Eicosapentaenoic Acid; EPA; Fatty Acids, Omega-3; Female; Humans; Inflammation; interleukin-10; interleukin-6; Male; Monocytes; postmenopause; Randomized crossover trial; Specialized pro-resolving lipid mediators; Randomized crossover trial; Monocytes; Inflammation; DHA; Specialized pro-resolving lipid mediators; EPA

The independent effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on chronic inflammation through their downstream lipid mediators, including the specialized pro-resolving lipid mediators (SPM), remain unstudied. Therefore, we compared the effects of EPA and DHA supplementation o...