A Computational Understanding of Inter-Individual Variability in CYP2D6 Activity to Investigate the Impact of Missense Mutations on Ochratoxin A Metabolism

• Published in: Toxins Vol. 14; no. 3; p. 207
• Main Authors: Dorne, Jean Lou C M, Cirlini, Martina, Louisse, Jochem, Pedroni, Lorenzo, Galaverna, Gianni, Dellafiora, Luca
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.03.2022; MDPI
• Subjects: Binding sites; Computer applications; CYP2D6; CYP2D6 protein; Cytochrome P-450 CYP2D6 - genetics; Cytochrome P-450 CYP2D6 - metabolism; Cytochrome P-450 Enzyme System - genetics; Cytochrome P450; Cytochromes; Enzymes; Food; Food safety; Haplotypes; Hazard assessment; Ligands; Metabolism; Metabolites; Missense mutation; Molecular modelling; Mutation; Mutation, Missense; Mycotoxins; Ochratoxin A; Ochratoxins - toxicity; Oxidation; Parameter identification; polymorphism metabolism; Polymorphism, Genetic; Proteins; Substrates; toxicokinetics; Xenobiotics; Xenobiotics - metabolism; food safety; hazard assessment; polymorphism metabolism; toxicokinetics; ochratoxin A; CYP2D6

Cytochrome P-450 (CYP) enzymes have a key role in the metabolism of xenobiotics of food origin, and their highly polymorphic nature concurs with the diverse inter-individual variability in the toxicokinetics (TK) and toxicodynamics (TD) of food chemicals. Ochratoxin A is a well-known mycotoxin which...