Diet Complexity and Estrogen Receptor β Status Affect the Composition of the Murine Intestinal Microbiota

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Published inApplied and Environmental Microbiology Vol. 79; no. 18; pp. 5763 - 5773
Main Authors MENON, Rani, WATSON, Sara E, THOMAS, Laura N, ALLRED, Clinton D, DABNEY, Alan, AZCARATE-PERIL, M. Andrea, STURINO, Joseph M
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.09.2013
Subjects
Animals
Bacteria - classification
Bacteria - genetics
Biological and medical sciences
Biota
Cluster Analysis
Diet - methods
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
DNA, Ribosomal - chemistry
DNA, Ribosomal - genetics
Estrogen Receptor beta - deficiency
Estrogen Receptor beta - metabolism
Fundamental and applied biological sciences. Psychology
Gastrointestinal Tract - microbiology
Isoflavones - administration & dosage
Mice
Mice, Inbred C57BL
Mice, Knockout
Microbial Ecology
Microbiology
Phylogeny
RNA, Ribosomal, 16S - genetics
Sequence Analysis, DNA
Estrogen receptor
Vertebrata
Mammalia
Diet
Mouse
Rodentia
Gut
Microflora
Hormonal receptor
Online AccessGet full text

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Abstract Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue AEM About AEM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AEM RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0099-2240 Online ISSN: 1098-5336 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AEM .asm.org, visit: AEM       
AbstractList Intestinal microbial dysbiosis contributes to the dysmetabolism of luminal factors, including steroid hormones (sterones) that affect the development of chronic gastrointestinal inflammation and the incidence of sterone-responsive cancers of the breast, prostate, and colon. Little is known, however, about the role of specific host sterone nucleoreceptors, including estrogen receptor β (ERβ), in microbiota maintenance. Herein, we test the hypothesis that ERβ status affects microbiota composition and determine if such compositionally distinct microbiota respond differently to changes in diet complexity that favor Proteobacteria enrichment. To this end, conventionally raised female ERβ +/+ and ERβ −/− C57BL/6J mice (mean age of 27 weeks) were initially reared on 8604, a complex diet containing estrogenic isoflavones, and then fed AIN-76, an isoflavone-free semisynthetic diet, for 2 weeks. 16S rRNA gene surveys revealed that the fecal microbiota of 8604-fed mice and AIN-76-fed mice differed, as expected. The relative diversity of Proteobacteria , especially the Alphaproteobacteria and Gammaproteobacteria , increased significantly following the transition to AIN-76. Distinct patterns for beneficial Lactobacillales were exclusive to and highly abundant among 8604-fed mice, whereas several Proteobacteria were exclusive to AIN-76-fed mice. Interestingly, representative orders of the phyla Proteobacteria , Bacteroidetes , and Firmicutes , including the Lactobacillales , also differed as a function of murine ERβ status. Overall, these interactions suggest that sterone nucleoreceptor status and diet complexity may play important roles in microbiota maintenance. Furthermore, we envision that this model for gastrointestinal dysbiosis may be used to identify novel probiotics, prebiotics, nutritional strategies, and pharmaceuticals for the prevention and resolution of Proteobacteria -rich dysbiosis.
ABSTRACT Intestinal microbial dysbiosis contributes to the dysmetabolism of luminal factors, including steroid hormones (sterones) that affect the development of chronic gastrointestinal inflammation and the incidence of sterone-responsive cancers of the breast, prostate, and colon. Little is known, however, about the role of specific host sterone nucleoreceptors, including estrogen receptor β (ERβ), in microbiota maintenance. Herein, we test the hypothesis that ERβ status affects microbiota composition and determine if such compositionally distinct microbiota respond differently to changes in diet complexity that favor Proteobacteria enrichment. To this end, conventionally raised female ERβ +/+ and ERβ −/− C57BL/6J mice (mean age of 27 weeks) were initially reared on 8604, a complex diet containing estrogenic isoflavones, and then fed AIN-76, an isoflavone-free semisynthetic diet, for 2 weeks. 16S rRNA gene surveys revealed that the fecal microbiota of 8604-fed mice and AIN-76-fed mice differed, as expected. The relative diversity of Proteobacteria , especially the Alphaproteobacteria and Gammaproteobacteria , increased significantly following the transition to AIN-76. Distinct patterns for beneficial Lactobacillales were exclusive to and highly abundant among 8604-fed mice, whereas several Proteobacteria were exclusive to AIN-76-fed mice. Interestingly, representative orders of the phyla Proteobacteria , Bacteroidetes , and Firmicutes , including the Lactobacillales , also differed as a function of murine ERβ status. Overall, these interactions suggest that sterone nucleoreceptor status and diet complexity may play important roles in microbiota maintenance. Furthermore, we envision that this model for gastrointestinal dysbiosis may be used to identify novel probiotics, prebiotics, nutritional strategies, and pharmaceuticals for the prevention and resolution of Proteobacteria -rich dysbiosis.
Intestinal microbial dysbiosis contributes to the dysmetabolism of luminal factors, including steroid hormones (sterones) that affect the development of chronic gastrointestinal inflammation and the incidence of sterone-responsive cancers of the breast, prostate, and colon. Little is known, however, about the role of specific host sterone nucleoreceptors, including estrogen receptor β (ERβ), in microbiota maintenance. Herein, we test the hypothesis that ERβ status affects microbiota composition and determine if such compositionally distinct microbiota respond differently to changes in diet complexity that favor Proteobacteria enrichment. To this end, conventionally raised female ERβ(+/+) and ERβ(-/-) C57BL/6J mice (mean age of 27 weeks) were initially reared on 8604, a complex diet containing estrogenic isoflavones, and then fed AIN-76, an isoflavone-free semisynthetic diet, for 2 weeks. 16S rRNA gene surveys revealed that the fecal microbiota of 8604-fed mice and AIN-76-fed mice differed, as expected. The relative diversity of Proteobacteria, especially the Alphaproteobacteria and Gammaproteobacteria, increased significantly following the transition to AIN-76. Distinct patterns for beneficial Lactobacillales were exclusive to and highly abundant among 8604-fed mice, whereas several Proteobacteria were exclusive to AIN-76-fed mice. Interestingly, representative orders of the phyla Proteobacteria, Bacteroidetes, and Firmicutes, including the Lactobacillales, also differed as a function of murine ERβ status. Overall, these interactions suggest that sterone nucleoreceptor status and diet complexity may play important roles in microbiota maintenance. Furthermore, we envision that this model for gastrointestinal dysbiosis may be used to identify novel probiotics, prebiotics, nutritional strategies, and pharmaceuticals for the prevention and resolution of Proteobacteria-rich dysbiosis.
Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue AEM About AEM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AEM RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0099-2240 Online ISSN: 1098-5336 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AEM .asm.org, visit: AEM       
Author Rani Menon
Clinton D. Allred
M. Andrea Azcarate-Peril
Alan Dabney
Joseph M. Sturino
Sara E. Watson
Laura N. Thomas
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  surname: MENON
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  organization: Nutrition and Food Science Department, Texas A&M University, College Station, Texas, United States
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  surname: WATSON
  fullname: WATSON, Sara E
  organization: Nutrition and Food Science Department, Texas A&M University, College Station, Texas, United States
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  givenname: Laura N
  surname: THOMAS
  fullname: THOMAS, Laura N
  organization: Nutrition and Food Science Department, Texas A&M University, College Station, Texas, United States
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  givenname: Clinton D
  surname: ALLRED
  fullname: ALLRED, Clinton D
  organization: Nutrition and Food Science Department, Texas A&M University, College Station, Texas, United States
– sequence: 5
  givenname: Alan
  surname: DABNEY
  fullname: DABNEY, Alan
  organization: Statistics Department, Texas A&M University, College Station, Texas, United States
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  surname: STURINO
  fullname: STURINO, Joseph M
  organization: Nutrition and Food Science Department, Texas A&M University, College Station, Texas, United States
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Keywords Estrogen receptor
Vertebrata
Mammalia
Diet
Mouse
Rodentia
Gut
Microflora
Hormonal receptor
Language English
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SSID ssj0004068
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Snippet Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit...
Intestinal microbial dysbiosis contributes to the dysmetabolism of luminal factors, including steroid hormones (sterones) that affect the development of...
ABSTRACT Intestinal microbial dysbiosis contributes to the dysmetabolism of luminal factors, including steroid hormones (sterones) that affect the development...
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StartPage 5763
SubjectTerms Animals
Bacteria - classification
Bacteria - genetics
Biological and medical sciences
Biota
Cluster Analysis
Diet - methods
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
DNA, Ribosomal - chemistry
DNA, Ribosomal - genetics
Estrogen Receptor beta - deficiency
Estrogen Receptor beta - metabolism
Fundamental and applied biological sciences. Psychology
Gastrointestinal Tract - microbiology
Isoflavones - administration & dosage
Mice
Mice, Inbred C57BL
Mice, Knockout
Microbial Ecology
Microbiology
Phylogeny
RNA, Ribosomal, 16S - genetics
Sequence Analysis, DNA
Title Diet Complexity and Estrogen Receptor β Status Affect the Composition of the Murine Intestinal Microbiota
URI http://aem.asm.org/content/79/18/5763.abstract
https://www.ncbi.nlm.nih.gov/pubmed/23872567
https://search.proquest.com/docview/1427746657
https://pubmed.ncbi.nlm.nih.gov/PMC3754184
Volume 79
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