In vitro effects of nonesterified fatty acids and β-hydroxybutyric acid on inflammatory cytokine expression in bovine peripheral blood leukocytes

• Published in: Italian journal of animal science Vol. 20; no. 1; pp. 2197 - 2210
• Main Authors: Li, Cheng-Yan, Liao, Yu-Wen, Liu, Chia-So, Cheng, Chuen-Yu, Chan, Jacky Peng-Wen, Wang, Chien-Kai
• Format: Journal Article
• Language: English
• Published: Bologna Taylor & Francis 01.01.2021; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: animal science; Blood levels; bovine peripheral blood leukocytes; Cytokines; Dairy cattle; Energy balance; Fatty acids; Holstein; IL-1β; Immunoregulation; inflammatory cytokines; Inflammatory diseases; Interleukin 10; Interleukin 6; Interleukin 8; Leukocytes (mononuclear); Leukocytes (polymorphonuclear); Lipopolysaccharides; Negative energy balance; nonesterified fatty acids; Peripheral blood mononuclear cells; Risk factors; risk reduction; Tumor necrosis factor-α; β-hydroxybutyric acid

Negative energy balance (NEB) occurs in dairy cows during the transition period, during which time the blood concentrations of nonesterified fatty acids (NEFA) and metabolic ketones such as β-hydroxybutyric acid (BHBA) are elevated. These increased levels may disrupt immune functions and are regarde...