Hypoxia Inducible Factor-1–Independent Pathways in Tumor Angiogenesis

• Published in: Clinical cancer research Vol. 13; no. 19; pp. 5670 - 5674
• Main Authors: Mizukami, Yusuke, Kohgo, Yutaka, Chung, Daniel C.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.10.2007
• Subjects: Angiogenesis; Angiogenesis and Microcirculation; Angiogenesis Inhibitors - therapeutic use; Antineoplastic agents; Antineoplastic Agents - therapeutic use; Biological and medical sciences; Gene Expression Regulation, Neoplastic; HIF; Humans; Hypoxia; Hypoxia-Inducible Factor 1 - metabolism; Hypoxia-Inducible Factor 1 - physiology; Medical sciences; Models, Biological; Neoplasm Transplantation; Neoplasms - blood supply; Neoplasms - metabolism; Neoplasms - pathology; Neovascularization, Pathologic; Pharmacology. Drug treatments; Signal Transduction; Vascular Endothelial Growth Factor A - antagonists & inhibitors; Vascular Endothelial Growth Factor A - metabolism; VEGF; Angiogenesis; Transcription factor HIF1; Neovascularization; Malignant tumor

Among the factors that can stimulate angiogenesis, vascular endothelial growth factor has emerged as one of the most important, and inhibition of vascular endothelial growth factor has recently shown efficacy in the treatment of advanced colorectal cancer. Hypoxia develops within solid tumors and is...