Hypoxia Inducible Factor-1–Independent Pathways in Tumor Angiogenesis
Among the factors that can stimulate angiogenesis, vascular endothelial growth factor has emerged as one of the most important, and inhibition of vascular endothelial growth factor has recently shown efficacy in the treatment of advanced colorectal cancer. Hypoxia develops within solid tumors and is...
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| Published in | Clinical cancer research Vol. 13; no. 19; pp. 5670 - 5674 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Philadelphia, PA
American Association for Cancer Research
01.10.2007
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Among the factors that can stimulate angiogenesis, vascular endothelial growth factor has emerged as one of the most important,
and inhibition of vascular endothelial growth factor has recently shown efficacy in the treatment of advanced colorectal cancer.
Hypoxia develops within solid tumors and is one of the most potent stimuli of vascular endothelial growth factor expression.
This effect is mediated primarily by hypoxia inducible factor-1 (HIF-1), often considered a master regulator of angiogenesis
in hypoxia. Consequently, inhibition of HIF-1 has been proposed as a strategy to block tumor angiogenesis therapeutically.
However, accumulating evidence indicates that HIF-independent pathways can also control angiogenesis. This review highlights
some of the key signaling pathways independent of HIF-1 that can stimulate angiogenesis in hypoxia. Understanding the full
spectrum of molecular pathways that control tumor angiogenesis is critical for the optimal design of targeted therapies. |
|---|---|
| AbstractList | Among the factors that can stimulate angiogenesis, vascular endothelial growth factor has emerged as one of the most important, and inhibition of vascular endothelial growth factor has recently shown efficacy in the treatment of advanced colorectal cancer. Hypoxia develops within solid tumors and is one of the most potent stimuli of vascular endothelial growth factor expression. This effect is mediated primarily by hypoxia inducible factor-1 (HIF-1), often considered a master regulator of angiogenesis in hypoxia. Consequently, inhibition of HIF-1 has been proposed as a strategy to block tumor angiogenesis therapeutically. However, accumulating evidence indicates that HIF-independent pathways can also control angiogenesis. This review highlights some of the key signaling pathways independent of HIF-1 that can stimulate angiogenesis in hypoxia. Understanding the full spectrum of molecular pathways that control tumor angiogenesis is critical for the optimal design of targeted therapies. Among the factors that can stimulate angiogenesis, vascular endothelial growth factor has emerged as one of the most important, and inhibition of vascular endothelial growth factor has recently shown efficacy in the treatment of advanced colorectal cancer. Hypoxia develops within solid tumors and is one of the most potent stimuli of vascular endothelial growth factor expression. This effect is mediated primarily by hypoxia inducible factor-1 (HIF-1), often considered a master regulator of angiogenesis in hypoxia. Consequently, inhibition of HIF-1 has been proposed as a strategy to block tumor angiogenesis therapeutically. However, accumulating evidence indicates that HIF-independent pathways can also control angiogenesis. This review highlights some of the key signaling pathways independent of HIF-1 that can stimulate angiogenesis in hypoxia. Understanding the full spectrum of molecular pathways that control tumor angiogenesis is critical for the optimal design of targeted therapies. Among the factors that can stimulate angiogenesis, vascular endothelial growth factor has emerged as one of the most important, and inhibition of vascular endothelial growth factor has recently shown efficacy in the treatment of advanced colorectal cancer. Hypoxia develops within solid tumors and is one of the most potent stimuli of vascular endothelial growth factor expression. This effect is mediated primarily by hypoxia inducible factor-1 (HIF-1), often considered a master regulator of angiogenesis in hypoxia. Consequently, inhibition of HIF-1 has been proposed as a strategy to block tumor angiogenesis therapeutically. However, accumulating evidence indicates that HIF-independent pathways can also control angiogenesis. This review highlights some of the key signaling pathways independent of HIF-1 that can stimulate angiogenesis in hypoxia. Understanding the full spectrum of molecular pathways that control tumor angiogenesis is critical for the optimal design of targeted therapies.Among the factors that can stimulate angiogenesis, vascular endothelial growth factor has emerged as one of the most important, and inhibition of vascular endothelial growth factor has recently shown efficacy in the treatment of advanced colorectal cancer. Hypoxia develops within solid tumors and is one of the most potent stimuli of vascular endothelial growth factor expression. This effect is mediated primarily by hypoxia inducible factor-1 (HIF-1), often considered a master regulator of angiogenesis in hypoxia. Consequently, inhibition of HIF-1 has been proposed as a strategy to block tumor angiogenesis therapeutically. However, accumulating evidence indicates that HIF-independent pathways can also control angiogenesis. This review highlights some of the key signaling pathways independent of HIF-1 that can stimulate angiogenesis in hypoxia. Understanding the full spectrum of molecular pathways that control tumor angiogenesis is critical for the optimal design of targeted therapies. |
| Author | Yutaka Kohgo Daniel C. Chung Yusuke Mizukami |
| Author_xml | – sequence: 1 givenname: Yusuke surname: Mizukami fullname: Mizukami, Yusuke – sequence: 2 givenname: Yutaka surname: Kohgo fullname: Kohgo, Yutaka – sequence: 3 givenname: Daniel C. surname: Chung fullname: Chung, Daniel C. |
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| Cites_doi | 10.1016/S1535-6108(03)00077-1 10.1038/nm1294 10.1128/MCB.16.10.5221 10.1016/j.neulet.2006.08.038 10.1016/S1535-6108(03)00030-8 10.1074/jbc.272.1.601 10.1002/jcb.20568 10.1074/jbc.M001914200 10.1096/fj.03-0329fje 10.1074/jbc.M511763200 10.1016/j.ccr.2005.09.005 10.1074/jbc.M111415200 10.1126/science.1066373 10.1101/gad.1024602 10.1056/NEJMoa032691 10.1016/S0021-9258(18)99049-6 10.1038/nature04695 10.1074/jbc.M512546200 10.1016/j.ceb.2006.10.005 10.1073/pnas.0407617101 10.1091/mbc.e04-05-0374 10.1084/jem.20052124 10.1242/jcs.00286 10.1158/0008-5472.CAN-03-3017 10.1016/j.ccr.2004.08.011 10.1093/emboj/17.11.3005 10.1016/j.ccr.2004.06.009 10.1038/35036374 10.1128/MCB.24.17.7806-7819.2004 10.1016/j.ccr.2004.09.028 10.1158/1541-7786.MCR-06-0235 10.1038/43466 10.1101/gad.1455706 10.1073/pnas.0602235103 10.1158/0008-5472.CAN-06-0425 10.1074/jbc.M305146200 10.1126/science.1068592 10.1515/BC.2005.101 10.1128/MCB.22.6.1734-1741.2002 10.1200/JCO.2005.02.5635 10.4049/jimmunol.165.2.1013 10.1038/sj.onc.1206323 10.1161/01.ATV.0000258979.92828.bc 10.1158/0008-5472.CAN-04-3671 10.1158/1078-0432.CCR-0953-03 10.1073/pnas.92.12.5510 10.1158/0008-5472.CAN-03-3176 10.1128/MCB.21.10.3436-3444.2001 |
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and inhibition of vascular... Among the factors that can stimulate angiogenesis, vascular endothelial growth factor has emerged as one of the most important, and inhibition of vascular... |
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| SubjectTerms | Angiogenesis Angiogenesis and Microcirculation Angiogenesis Inhibitors - therapeutic use Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences Gene Expression Regulation, Neoplastic HIF Humans Hypoxia Hypoxia-Inducible Factor 1 - metabolism Hypoxia-Inducible Factor 1 - physiology Medical sciences Models, Biological Neoplasm Transplantation Neoplasms - blood supply Neoplasms - metabolism Neoplasms - pathology Neovascularization, Pathologic Pharmacology. Drug treatments Signal Transduction Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - metabolism VEGF |
| Title | Hypoxia Inducible Factor-1–Independent Pathways in Tumor Angiogenesis |
| URI | http://clincancerres.aacrjournals.org/content/13/19/5670.abstract https://www.ncbi.nlm.nih.gov/pubmed/17908955 https://www.proquest.com/docview/68331017 |
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