Gene Sequencing for Routine Verification of Pyrazinamide Resistance in Mycobacterium tuberculosis: a Role for pncA but Not rpsA

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Published inJournal of Clinical Microbiology Vol. 50; no. 11; pp. 3726 - 3728
Main Authors ALEXANDER, David C, MA, Jennifer H, GUTHRIE, Jennifer L, BLAIR, Joanne, CHEDORE, Pam, JAMIESON, Frances B
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.11.2012
Subjects
Amidohydrolases - genetics
Antitubercular Agents - pharmacology
Bacteriology
Biological and medical sciences
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
Drug Resistance, Bacterial
Fundamental and applied biological sciences. Psychology
Humans
Microbial Sensitivity Tests - methods
Microbiology
Miscellaneous
Mycobacteriology and Aerobic Actinomycetes
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Pyrazinamide - pharmacology
Sequence Analysis, DNA - methods
Tuberculosis - microbiology
Resistance
Gene
Mycobacterium tuberculosis
Mycobacteriales
Mycobacteriaceae
Bacteria
Actinomycetes
Antituberculous agent
Antibacterial agent
Pyrazinamide
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Abstract Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JCM About JCM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JCM RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0095-1137 Online ISSN: 1098-660X Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JCM .asm.org, visit: JCM       
AbstractList Pyrazinamide (PZA) is an important component of first-line therapy for the treatment of tuberculosis. Here, we evaluate targeted gene sequencing as a supplement to phenotypic PZA susceptibility testing of Mycobacterium tuberculosis. Routine sequencing of pncA, but not rpsA, is effective for verification of PZA susceptibility results.
ABSTRACT Pyrazinamide (PZA) is an important component of first-line therapy for the treatment of tuberculosis. Here, we evaluate targeted gene sequencing as a supplement to phenotypic PZA susceptibility testing of Mycobacterium tuberculosis . Routine sequencing of pncA , but not rpsA , is effective for verification of PZA susceptibility results.
Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JCM About JCM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JCM RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0095-1137 Online ISSN: 1098-660X Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JCM .asm.org, visit: JCM       
Pyrazinamide (PZA) is an important component of first-line therapy for the treatment of tuberculosis. Here, we evaluate targeted gene sequencing as a supplement to phenotypic PZA susceptibility testing of Mycobacterium tuberculosis . Routine sequencing of pncA , but not rpsA , is effective for verification of PZA susceptibility results.
Author Frances B. Jamieson
David C. Alexander
Joanne Blair
Jennifer L. Guthrie
Jennifer H. Ma
Pam Chedore
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Keywords Resistance
Gene
Mycobacterium tuberculosis
Mycobacteriales
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Bacteria
Actinomycetes
Antituberculous agent
Antibacterial agent
Pyrazinamide
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Pyrazinamide (PZA) is an important component of first-line therapy for the treatment of tuberculosis. Here, we evaluate targeted gene sequencing as a...
ABSTRACT Pyrazinamide (PZA) is an important component of first-line therapy for the treatment of tuberculosis. Here, we evaluate targeted gene sequencing as a...
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SubjectTerms Amidohydrolases - genetics
Antitubercular Agents - pharmacology
Bacteriology
Biological and medical sciences
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
Drug Resistance, Bacterial
Fundamental and applied biological sciences. Psychology
Humans
Microbial Sensitivity Tests - methods
Microbiology
Miscellaneous
Mycobacteriology and Aerobic Actinomycetes
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Pyrazinamide - pharmacology
Sequence Analysis, DNA - methods
Tuberculosis - microbiology
Title Gene Sequencing for Routine Verification of Pyrazinamide Resistance in Mycobacterium tuberculosis: a Role for pncA but Not rpsA
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