Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines

The in vitro evaluation of thieno[3,2-d]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer cell lines. A structure activity relationship study indicated the necessity of the chlorine at the C4-position for biological activity. The two...

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Published inBioorganic & medicinal chemistry Vol. 22; no. 7; pp. 2113 - 2122
Main Authors Temburnikar, Kartik W., Zimmermann, Sarah C., Kim, Nathaniel T., Ross, Christina R., Gelbmann, Christopher, Salomon, Christine E., Wilson, Gerald M., Balzarini, Jan, Seley-Radtke, Katherine L.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.04.2014
Elsevier
Subjects
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antifungal
Antifungal Agents - chemical synthesis
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Apoptosis
Apoptosis - drug effects
Bacillus subtilis - drug effects
Biochemistry & Molecular Biology
Cell Cycle - drug effects
Cell Proliferation - drug effects
Chemistry
Chemistry, Medicinal
Chemistry, Organic
Cytostatic
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Fungi - drug effects
Heterocyclic chemistry
Humans
Life Sciences & Biomedicine
Microbial Sensitivity Tests
Molecular Structure
Pharmacology & Pharmacy
Physical Sciences
Pyrimidines - chemical synthesis
Pyrimidines - chemistry
Pyrimidines - pharmacology
Science & Technology
Structure-Activity Relationship
Thieno[3,2-d]pyrimidine
Tumor Cells, Cultured
Thieno[3,2-d]pyrimidine
Heterocyclic chemistry
Antifungal
Cytostatic
Apoptosis
DESIGN
SERIES
KINASE INHIBITOR
CANCER
DISCOVERY
POTENT
PI3 KINASE
BIOLOGICAL EVALUATION
C-NUCLEOSIDE ISOSTERE
DERIVATIVES
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Abstract The in vitro evaluation of thieno[3,2-d]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer cell lines. A structure activity relationship study indicated the necessity of the chlorine at the C4-position for biological activity. The two most active compounds 1 and 2 were found to induce apoptosis in the leukemia L1210 cell line. Additionally, the compounds were screened against a variety of other microbial targets and as a result, selective activity against several fungi was also observed. The synthesis and preliminary biological results are reported herein.
AbstractList The in vitro evaluation of thieno[3,2-d]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer cell lines. A structure activity relationship study indicated the necessity of the chlorine at the C4-position for biological activity. The two most active compounds 1 and 2 were found to induce apoptosis in the leukemia L1210 cell line. Additionally, the compounds were screened against a variety of other microbial targets and as a result, selective activity against several fungi was also observed. The synthesis and preliminary biological results are reported herein.
The in vitro evaluation of thieno[3,2-d]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer cell lines. A structure activity relationship study indicated the necessity of the chlorine at the C4-position for biological activity. The two most active compounds 1 and 2 were found to induce apoptosis in the leukemia L1210 cell line. Additionally, the compounds were screened against a variety of other microbial targets and as a result, selective activity against several fungi was also observed. The synthesis and preliminary biological results are reported herein. (C) 2014 Elsevier Ltd. All rights reserved.
The in vitro evaluation of thieno[3,2- d ]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer cell lines. A structure activity relationship study indicated the necessity of the chlorine at the C4-position for biological activity. The two most active compounds 1 and 2 were found to induce apoptosis in the leukemia L1210 cell line. Additionally, the compounds were screened against a variety of other microbial targets and as a result, selective activity against several fungi was also observed. The synthesis and preliminary biological results are reported herein.
Author Gelbmann, Christopher
Wilson, Gerald M.
Temburnikar, Kartik W.
Seley-Radtke, Katherine L.
Salomon, Christine E.
Zimmermann, Sarah C.
Ross, Christina R.
Kim, Nathaniel T.
Balzarini, Jan
AuthorAffiliation d Center for Drug Design, University of Minnesota, 516 Delaware St. SE, Minneapolis, MN 55455, USA
a Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
b Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene Street, Baltimore, MD 21201, USA
c Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium
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  givenname: Nathaniel T.
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  surname: Salomon
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  organization: Center for Drug Design, University of Minnesota, 516 Delaware St. SE, Minneapolis, MN 55455, USA
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  givenname: Gerald M.
  surname: Wilson
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  organization: Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene Street, Baltimore, MD 21201, USA
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  givenname: Jan
  surname: Balzarini
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  givenname: Katherine L.
  surname: Seley-Radtke
  fullname: Seley-Radtke, Katherine L.
  email: kseley@umbc.edu
  organization: Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
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Cites_doi 10.1021/jo0155613
10.1016/j.cell.2011.02.013
10.1021/jm0601809
10.1021/ol101482h
10.1021/jm2009327
10.1158/1535-7163.MCT-11-0446
10.1038/cdd.2008.131
10.1016/j.canlet.2010.12.012
10.1021/jm901284w
10.1021/ja9064359
10.1186/1476-4598-10-35
10.1016/j.bmc.2004.12.011
10.1016/j.tet.2007.01.075
10.1021/jo400913k
10.1080/15257770.2012.656212
10.1038/nrc1587
10.1081/NCN-200027660
10.1021/jm3003747
10.1016/j.bmc.2006.06.046
10.1016/j.bmcl.2003.10.030
10.1021/ml200198x
10.1021/jm000326i
10.2144/000113089
10.1021/ml100230n
10.1021/jm300016v
10.1016/j.canlet.2010.09.012
10.1021/jm800295d
10.1084/jem.97.5.695
10.1002/jhet.5570240354
10.1046/j.1359-4117.2002.01002.x
10.1021/jo00154a005
10.1016/S0040-4039(00)78826-5
10.1002/jhet.5570230631
10.1016/0040-4039(81)80031-7
10.1021/jm9903949
10.2174/1874467210801030244
10.1016/0022-1759(95)00072-I
10.1021/jm00117a019
10.1080/15257779408011862
10.1002/1097-0142(196504)18:4<522::AID-CNCR2820180418>3.0.CO;2-J
10.1021/jo00155a026
10.1021/jm981012m
10.1021/jo00145a005
10.1021/jm00014a027
10.1055/s-1974-23448
10.1016/j.tet.2008.09.011
10.1093/nass/nrn321
10.1080/15257779408011866
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Issue 7
Keywords Thieno[3,2-d]pyrimidine
Heterocyclic chemistry
Antifungal
Cytostatic
Apoptosis
DESIGN
SERIES
KINASE INHIBITOR
CANCER
DISCOVERY
POTENT
PI3 KINASE
BIOLOGICAL EVALUATION
C-NUCLEOSIDE ISOSTERE
DERIVATIVES
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References Fossey, Landelle, Laduree, Robba (b0110) 1994; 13
Munchhof, Beebe, Casavant, Cooper, Doty, Higdon, Hillerman, Soderstrom, Knauth, Marx, Rossi, Sobolov, Sun (b0060) 2004; 14
Sutherlin, Sampath, Berry, Castanedo, Chang, Chuckowree, Dotson, Folkes, Friedman, Goldsmith, Heffron, Lee, Lesnick, Lewis, Mathieu, Nonomiya, Olivero, Pang, Prior, Salphati, Sideris, Tian, Tsui, Wan, Wang, Wiesmann, Wong, Zhu (b0080) 2010; 53
Mathieu, Gradl, Ren, Wen, Aliagas, Gunzner-Toste, Lee, Pulk, Zhao, Alicke, Boggs, Buckmelter, Choo, Dinkel, Gloor, Gould, Hansen, Hastings, Hatzivassiliou, Laird, Moreno, Ran, Voegtli, Wenglowsky, Grina, Rudolph (b0095) 2012; 55
Wallace, Candlish, Hagos, Seley, De Koning (b0135) 2004; 23
Fossey, Laduree, Robba (b0105) 1994; 13
Guimaraes, Kopecky, Mihalic, Shen, Jeffries, Thibault, Chen, Walker, Cardozo (b0180) 2009; 131
Lemke, T. L.; Williams, D. A.; Editors Foye’s Principles of Medicinal Chemistry: Fifth edition, 2002.
Seley, Januszczyk, Hagos, Zhang, Dransfield (b0055) 2000; 43
Shi, Du, Ma, Pankiewicz, Patterson, Tharnish, McBrayer, Stuyver, Otto, Chu, Schinazi, Watanabe (b0160) 2005; 13
Foley, Lazarus, Farber, Uzman, Boone, McCarthy (b0195) 1965; 18
Lim, Klein, Fox (b0010) 1980; 21
Lim, Ren, Otter, Klein (b0025) 1983; 48
Joule, J. A.; Mills, K. Heterocyclic Chemistry: Fourth Edition, 2000.
Cory, Chen, Cory (b0240) 2006; 26
Ren, Rao, Klein (b0030) 1986; 23
Showalter, Bridges, Zhou, Sercel, McMichael, Fry (b0050) 1999; 42
‘Performance Standards for Antimicrobial Susceptibility Testing: 14th Informational Supplement’, National Committee for Clinical Laboratory Standards, 2004.
Eisele, Weller (b0260) 2013; 332
Ren, Lim, Otter, Klein (b0015) 1982; 47
Mollard, Warner, Call, Wade, Bearss, Verma, Sharma, Vankayalapati, Bearss (b0210) 2011; 2
Sutherlin, Bao, Berry, Castanedo, Chuckowree, Dotson, Folks, Friedman, Goldsmith, Gunzner, Heffron, Lesnick, Lewis, Mathieu, Murray, Nonomiya, Pang, Pegg, Prior, Rouge, Salphati, Sampath, Tian, Tsui, Wan, Wang, Wei, Wiesmann, Wu, Zhu, Olivero (b0085) 2011; 54
Pore, Hiltermann, Kruyt (b0265) 2013; 332
Vermes, Haanen, Steffens-Nakken, Reutelingsperger (b0275) 1995; 184
Neidle, Thurston (b0225) 2005; 5
Safina, Baker, Baumgardner, Blaney, Chan, Chen, Cartwright, Castanedo, Chabot, Cheguillaume, Goldsmith, Goldstein, Goyal, Hancox, Handa, Iyer, Kaur, Kondru, Kenny, Krintel, Li, Lesnick, Lucas, Lewis, Mukadam, Murray, Nadin, Nonomiya, Padilla, Palmer, Pang, Pegg, Price, Reif, Salphati, Savy, Seward, Shuttleworth, Sohal, Sweeney, Tay, Tivitmahaisoon, Waszkowycz, Wei, Yue, Zhang, Sutherlin (b0100) 2012; 55
Girgis, Cottam, Larson, Robins (b0185) 1987; 24
Bourke, Burns, Cuzzupe, Feutrill, Kling, Nero (b0150) 2009
Ife, Brown, Blurton, Keeling, Leach, Meeson, Parsons, Theobald (b0040) 1995; 38
Tor, Del Valle, Jaramillo, Srivatsan, Rios, Weizman (b0115) 2007; 63
Temburnikar, Zhang, Seley-Radtke (b0145) 2012; 31
Evans, Furneaux, Hutchison, Kezar, Morris, Schramm, Tyler (b0175) 2001; 66
Kikuchi, Yamamoto, Horoiwa, Hirai, Kasahara, Hariguchi, Matsumoto, Oshima (b0065) 2006; 49
Seley-Radtke, Zhang, Wauchope, Zimmermann, Ivanov, Korba (b0120) 2008; 52
Hayakawa, Kaizawa, Moritomo, Koizumi, Ohishi, Okada, Ohta, Tsukamoto, Parker, Workman, Waterfield (b0070) 2006; 14
Kelly, Lopez-Chavez, Citrin, Janik, Morris (b0255) 2011; 10
Cupps, Wise, Townsend (b0170) 1983; 48
Hanahan, Weinberg Robert (b0250) 2011; 144
Bravo-Altamirano, George, Frantz, LaValle, Tandon, Leimgruber, Sharlow, Lazo, Wang, Wipf (b0155) 2011; 2
Lim, Klein (b0020) 1981; 22
Wade, L. G. Organic Chemistry, 4th Edition, 1998.
Wallin, Edgar, Guan, Berry, Prior, Lee, Lesnick, Lewis, Nonomiya, Pang, Salphati, Olivero, Sutherlin, O’Brien, Spoerke, Patel, Lensun, Kassees, Ross, Lackner, Sampath, Belvin, Friedman (b0090) 2011; 10
Rahbari, R.; Sheahan, T.; Modes, V.; Collier, P.; Macfarlane, C.; Badge, R. M. BioTechniques 2009, 46, 277–278, 280, 282, 284.
Zhang, Wauchope, Seley-Radtke (b0125) 2008; 64
Law, Dunn (b0190) 1949; 10
Temburnikar, Brace, Seley-Radtke (b0140) 2013; 78
Maiuri, Tasdemir, Criollo, Morselli, Vicencio, Carnuccio, Kroemer (b0235) 2009; 16
Scherer, Syverton, Gey (b0200) 1953; 97
Russell, Press, Rampulla, McNally, Falotico, Keiser, Bright, Tobia (b0035) 1988; 31
Wauchope, Tomney, Pepper, Korba, Seley-Radtke (b0130) 2010; 12
Sullivan, Garcia-Welch, White, Lutzker, Hait (b0245) 2002; 2
Richardson, Kaye (b0270) 2008; 1
Crespo, Pages, Vega, Segarra, Lopez, Domenech, Miralpeix, Beleta, Ryder, Palacios (b0045) 1998; 41
Folkes, Ahmadi, Alderton, Alix, Baker, Box, Chuckowree, Clarke, Depledge, Eccles, Friedman, Hayes, Hancox, Kugendradas, Lensun, Moore, Olivero, Pang, Patel, Pergl-Wilson, Raynaud, Robson, Saghir, Salphati, Sohal, Ultsch, Valenti, Wallweber, Wan, Wiesmann, Workman, Zhyvoloup, Zvelebil, Shuttleworth (b0075) 2008; 51
Amarnath, Madhav (b0005) 1974
(b0230) 2002
Kelly, RJ (WOS:000289941600001) 2011; 10
(000334337800011.40) 1000
LIM, MI (WOS:A1983QH60600005) 1983; 48
Seley, KL (WOS:000165866100017) 2000; 43
FOLEY, GE (WOS:A19656307400016) 1965; 18
Sutherlin, DP (WOS:000296408100014) 2011; 54
Rahbari, R (WOS:000266095900005) 2009; 46
LAW, LW (WOS:A1949UF24900018) 1949; 10
Hayakawa, M (WOS:000241227400006) 2006; 14
Joule, J. A. (000334337800011.19) 2000; Fourth
REN, WY (WOS:A1982PR58400005) 1982; 47
(000334337800011.4) 2002
Richardson, Alan (MEDLINE:20021437) 2008; 1
(000334337800011.23) 1000
Neidle, S (WOS:000228091000014) 2005; 5
LIM, MI (WOS:A1981KX03600007) 1981; 22
Folkes, AJ (WOS:000259342700007) 2008; 51
(000334337800011.1) 1000
Pore, MM (WOS:000318378200027) 2013; 332
Mathieu, S (WOS:000301767000029) 2012; 55
Shi, JX (WOS:000227251300024) 2005; 13
Bravo-Altamirano, K (WOS:000287297200012) 2011; 2
Wallace, LJM (WOS:000225113700069) 2004; 23
Wallin, JJ (WOS:000298344400021) 2011; 10
LIM, MI (WOS:A1980JH42000007) 1980; 21
Maiuri, MC (WOS:000261693600011) 2009; 16
CUPPS, TL (WOS:A1983QK09500026) 1983; 48
Mollard, A (WOS:000297947000007) 2011; 2
Temburnikar, K (WOS:000322210700051) 2013; 78
Sutherlin, DP (WOS:000274270900016) 2010; 53
Eisele, G (WOS:000318378200025) 2013; 332
Wauchope, OR (WOS:000282604700009) 2010; 12
Safina, BS (WOS:000305769600018) 2012; 55
FOSSEY, C (WOS:A1994NL49000005) 1994; 13
REN, WY (WOS:A1986F587500031) 1986; 23
Temburnikar, K (WOS:000303579100004) 2012; 31
GIRGIS, NS (WOS:A1987H627300054) 1987; 24
Crespo, MI (WOS:000076374300013) 1998; 41
Kikuchi, H (WOS:000239141500029) 2006; 49
AMARNATH, V (WOS:A1974V163200001) 1974
(000334337800011.51) 1000
FOSSEY, C (WOS:A1994NL49000001) 1994; 13
Sullivan, Gregory F (MEDLINE:12415616); 2
Tor, Y (WOS:000248294800021) 2007; 63
Guimaraes, CRW (WOS:000273615400037) 2009; 131
Zhang, ZB (WOS:000260703200002) 2008; 64
Evans, GB (WOS:000170598900011) 2001; 66
SCHERER, WF (WOS:A1953UD35500008) 1953; 97
Showalter, HDH (WOS:000084640000015) 1999; 42
Cory, AH (WOS:000236674800063) 2006; 26
VERMES, I (WOS:A1995RL33700005) 1995; 184
RUSSELL, RK (WOS:A1988P883100019) 1988; 31
IFE, RJ (WOS:A1995RJ01400027) 1995; 38
Munchhof, MJ (WOS:000187862000001) 2004; 14
Hanahan, D (WOS:000288007100007) 2011; 144
Mollard (10.1016/j.bmc.2014.02.033_b0210) 2011; 2
Shi (10.1016/j.bmc.2014.02.033_b0160) 2005; 13
Ren (10.1016/j.bmc.2014.02.033_b0015) 1982; 47
Zhang (10.1016/j.bmc.2014.02.033_b0125) 2008; 64
Sutherlin (10.1016/j.bmc.2014.02.033_b0080) 2010; 53
Crespo (10.1016/j.bmc.2014.02.033_b0045) 1998; 41
Wallace (10.1016/j.bmc.2014.02.033_b0135) 2004; 23
Scherer (10.1016/j.bmc.2014.02.033_b0200) 1953; 97
Ren (10.1016/j.bmc.2014.02.033_b0030) 1986; 23
(10.1016/j.bmc.2014.02.033_b0230) 2002
Seley-Radtke (10.1016/j.bmc.2014.02.033_b0120) 2008; 52
10.1016/j.bmc.2014.02.033_b0215
Mathieu (10.1016/j.bmc.2014.02.033_b0095) 2012; 55
Amarnath (10.1016/j.bmc.2014.02.033_b0005) 1974
Showalter (10.1016/j.bmc.2014.02.033_b0050) 1999; 42
Guimaraes (10.1016/j.bmc.2014.02.033_b0180) 2009; 131
Fossey (10.1016/j.bmc.2014.02.033_b0110) 1994; 13
Neidle (10.1016/j.bmc.2014.02.033_b0225) 2005; 5
Kelly (10.1016/j.bmc.2014.02.033_b0255) 2011; 10
10.1016/j.bmc.2014.02.033_b0220
Tor (10.1016/j.bmc.2014.02.033_b0115) 2007; 63
Temburnikar (10.1016/j.bmc.2014.02.033_b0140) 2013; 78
Safina (10.1016/j.bmc.2014.02.033_b0100) 2012; 55
Vermes (10.1016/j.bmc.2014.02.033_b0275) 1995; 184
Lim (10.1016/j.bmc.2014.02.033_b0020) 1981; 22
Foley (10.1016/j.bmc.2014.02.033_b0195) 1965; 18
10.1016/j.bmc.2014.02.033_b0205
Law (10.1016/j.bmc.2014.02.033_b0190) 1949; 10
Folkes (10.1016/j.bmc.2014.02.033_b0075) 2008; 51
Seley (10.1016/j.bmc.2014.02.033_b0055) 2000; 43
Maiuri (10.1016/j.bmc.2014.02.033_b0235) 2009; 16
Ife (10.1016/j.bmc.2014.02.033_b0040) 1995; 38
Temburnikar (10.1016/j.bmc.2014.02.033_b0145) 2012; 31
Bravo-Altamirano (10.1016/j.bmc.2014.02.033_b0155) 2011; 2
Wallin (10.1016/j.bmc.2014.02.033_b0090) 2011; 10
Hayakawa (10.1016/j.bmc.2014.02.033_b0070) 2006; 14
Lim (10.1016/j.bmc.2014.02.033_b0025) 1983; 48
Lim (10.1016/j.bmc.2014.02.033_b0010) 1980; 21
Hanahan (10.1016/j.bmc.2014.02.033_b0250) 2011; 144
Richardson (10.1016/j.bmc.2014.02.033_b0270) 2008; 1
Cupps (10.1016/j.bmc.2014.02.033_b0170) 1983; 48
Pore (10.1016/j.bmc.2014.02.033_b0265) 2013; 332
Kikuchi (10.1016/j.bmc.2014.02.033_b0065) 2006; 49
Evans (10.1016/j.bmc.2014.02.033_b0175) 2001; 66
Munchhof (10.1016/j.bmc.2014.02.033_b0060) 2004; 14
Bourke (10.1016/j.bmc.2014.02.033_b0150) 2009
Girgis (10.1016/j.bmc.2014.02.033_b0185) 1987; 24
Sullivan (10.1016/j.bmc.2014.02.033_b0245) 2002; 2
Russell (10.1016/j.bmc.2014.02.033_b0035) 1988; 31
Fossey (10.1016/j.bmc.2014.02.033_b0105) 1994; 13
10.1016/j.bmc.2014.02.033_b0165
Cory (10.1016/j.bmc.2014.02.033_b0240) 2006; 26
Eisele (10.1016/j.bmc.2014.02.033_b0260) 2013; 332
Sutherlin (10.1016/j.bmc.2014.02.033_b0085) 2011; 54
10.1016/j.bmc.2014.02.033_b0280
Wauchope (10.1016/j.bmc.2014.02.033_b0130) 2010; 12
References_xml – volume: 144
  start-page: 646
  year: 2011
  ident: b0250
  publication-title: Cell
  contributor:
    fullname: Weinberg Robert
– volume: 64
  start-page: 10791
  year: 2008
  ident: b0125
  publication-title: Tetrahedron
  contributor:
    fullname: Seley-Radtke
– volume: 24
  start-page: 821
  year: 1987
  ident: b0185
  publication-title: J. Heterocycl. Chem.
  contributor:
    fullname: Robins
– volume: 13
  start-page: 925
  year: 1994
  ident: b0110
  article-title: Nucleosides
  publication-title: Nucleotides Nucleic Acids
  contributor:
    fullname: Robba
– volume: 41
  start-page: 4021
  year: 1998
  ident: b0045
  publication-title: J. Med. Chem.
  contributor:
    fullname: Palacios
– volume: 49
  start-page: 4698
  year: 2006
  ident: b0065
  publication-title: J. Med. Chem.
  contributor:
    fullname: Oshima
– volume: 52
  start-page: 635
  year: 2008
  ident: b0120
  publication-title: Nucleic Acids Symp. Ser.
  contributor:
    fullname: Korba
– year: 2002
  ident: b0230
  publication-title: The Molecular Basis of Human Cancer
– volume: 47
  start-page: 4633
  year: 1982
  ident: b0015
  publication-title: J. Org. Chem.
  contributor:
    fullname: Klein
– volume: 23
  start-page: 1441
  year: 2004
  ident: b0135
  article-title: Nucleosides
  publication-title: Nucleotides Nucleic Acids
  contributor:
    fullname: De Koning
– volume: 184
  start-page: 39
  year: 1995
  ident: b0275
  publication-title: J. Immunol. Methods
  contributor:
    fullname: Reutelingsperger
– volume: 23
  start-page: 1757
  year: 1986
  ident: b0030
  publication-title: J. Heterocycl. Chem.
  contributor:
    fullname: Klein
– volume: 10
  start-page: 2426
  year: 2011
  ident: b0090
  publication-title: Mol. Cancer Ther.
  contributor:
    fullname: Friedman
– volume: 78
  start-page: 7305
  year: 2013
  ident: b0140
  publication-title: J. Org. Chem.
  contributor:
    fullname: Seley-Radtke
– volume: 55
  start-page: 2869
  year: 2012
  ident: b0095
  publication-title: J. Med. Chem.
  contributor:
    fullname: Rudolph
– volume: 13
  start-page: 1641
  year: 2005
  ident: b0160
  publication-title: Bioorg. Med. Chem.
  contributor:
    fullname: Watanabe
– volume: 10
  start-page: 179
  year: 1949
  ident: b0190
  publication-title: J. Natl. Cancer. Inst.
  contributor:
    fullname: Dunn
– volume: 48
  start-page: 1060
  year: 1983
  ident: b0170
  publication-title: J. Org. Chem.
  contributor:
    fullname: Townsend
– volume: 1
  start-page: 244
  year: 2008
  ident: b0270
  publication-title: Curr. Mol. Pharmacol.
  contributor:
    fullname: Kaye
– year: 2009
  ident: b0150
  article-title: Cytopia Research Pty Ltd, Australia
  contributor:
    fullname: Nero
– volume: 63
  start-page: 3608
  year: 2007
  ident: b0115
  publication-title: Tetrahedron
  contributor:
    fullname: Weizman
– volume: 26
  start-page: 1289
  year: 2006
  ident: b0240
  publication-title: Anticancer Res.
  contributor:
    fullname: Cory
– volume: 53
  start-page: 1086
  year: 2010
  ident: b0080
  publication-title: J. Med. Chem.
  contributor:
    fullname: Zhu
– volume: 55
  start-page: 5887
  year: 2012
  ident: b0100
  publication-title: J. Med. Chem.
  contributor:
    fullname: Sutherlin
– volume: 18
  start-page: 522
  year: 1965
  ident: b0195
  publication-title: Cancer
  contributor:
    fullname: McCarthy
– volume: 2
  start-page: 19
  year: 2002
  ident: b0245
  publication-title: J. Exp. Ther. Oncol.
  contributor:
    fullname: Hait
– volume: 2
  start-page: 154
  year: 2011
  ident: b0155
  publication-title: ACS Med. Chem. Lett.
  contributor:
    fullname: Wipf
– volume: 97
  start-page: 695
  year: 1953
  ident: b0200
  publication-title: J. Exp. Med.
  contributor:
    fullname: Gey
– volume: 21
  start-page: 1013
  year: 1980
  ident: b0010
  publication-title: Tetrahedron Lett.
  contributor:
    fullname: Fox
– volume: 66
  start-page: 5723
  year: 2001
  ident: b0175
  publication-title: J. Org. Chem.
  contributor:
    fullname: Tyler
– volume: 38
  start-page: 2763
  year: 1995
  ident: b0040
  publication-title: J. Med. Chem.
  contributor:
    fullname: Theobald
– volume: 43
  start-page: 4877
  year: 2000
  ident: b0055
  publication-title: J. Med. Chem.
  contributor:
    fullname: Dransfield
– volume: 14
  start-page: 6847
  year: 2006
  ident: b0070
  publication-title: Bioorg. Med. Chem.
  contributor:
    fullname: Waterfield
– volume: 22
  start-page: 25
  year: 1981
  ident: b0020
  publication-title: Tetrahedron Lett.
  contributor:
    fullname: Klein
– volume: 2
  start-page: 907
  year: 2011
  ident: b0210
  publication-title: ACS Med. Chem. Lett.
  contributor:
    fullname: Bearss
– volume: 5
  start-page: 285
  year: 2005
  ident: b0225
  publication-title: Nat. Rev. Cancer
  contributor:
    fullname: Thurston
– volume: 54
  start-page: 7579
  year: 2011
  ident: b0085
  publication-title: J. Med. Chem.
  contributor:
    fullname: Olivero
– volume: 10
  start-page: 35
  year: 2011
  ident: b0255
  publication-title: Mol. Cancer
  contributor:
    fullname: Morris
– volume: 13
  start-page: 883
  year: 1994
  ident: b0105
  article-title: Nucleosides
  publication-title: Nucleotides Nucleic Acids
  contributor:
    fullname: Robba
– volume: 332
  start-page: 359
  year: 2013
  ident: b0265
  publication-title: Cancer Lett.
  contributor:
    fullname: Kruyt
– volume: 12
  start-page: 4466
  year: 2010
  ident: b0130
  publication-title: Org. Lett.
  contributor:
    fullname: Seley-Radtke
– start-page: 837
  year: 1974
  ident: b0005
  publication-title: Synthesis
  contributor:
    fullname: Madhav
– volume: 31
  start-page: 319
  year: 2012
  ident: b0145
  publication-title: Nucleosides, Nucleotides, Nucleic Acids
  contributor:
    fullname: Seley-Radtke
– volume: 42
  start-page: 5464
  year: 1999
  ident: b0050
  publication-title: J. Med. Chem.
  contributor:
    fullname: Fry
– volume: 131
  start-page: 18139
  year: 2009
  ident: b0180
  publication-title: J. Am. Chem. Soc.
  contributor:
    fullname: Cardozo
– volume: 16
  start-page: 87
  year: 2009
  ident: b0235
  publication-title: Cell Death Differ.
  contributor:
    fullname: Kroemer
– volume: 332
  start-page: 335
  year: 2013
  ident: b0260
  publication-title: Cancer Lett.
  contributor:
    fullname: Weller
– volume: 51
  start-page: 5522
  year: 2008
  ident: b0075
  publication-title: J. Med. Chem.
  contributor:
    fullname: Shuttleworth
– volume: 14
  start-page: 21
  year: 2004
  ident: b0060
  publication-title: Bioorg. Med. Chem. Lett.
  contributor:
    fullname: Sun
– volume: 48
  start-page: 780
  year: 1983
  ident: b0025
  publication-title: J. Org. Chem.
  contributor:
    fullname: Klein
– volume: 31
  start-page: 1786
  year: 1988
  ident: b0035
  publication-title: J. Med. Chem.
  contributor:
    fullname: Tobia
– volume: 66
  start-page: 5723
  year: 2001
  ident: WOS:000170598900011
  article-title: Addition of lithiated 9-deazapurine derivatives to a carbohydrate cyclic imine: Convergent synthesis of the aza-C-nucleoside immucillins
  publication-title: JOURNAL OF ORGANIC CHEMISTRY
  doi: 10.1021/jo0155613
  contributor:
    fullname: Evans, GB
– volume: 144
  start-page: 646
  year: 2011
  ident: WOS:000288007100007
  article-title: Hallmarks of Cancer: The Next Generation
  publication-title: CELL
  doi: 10.1016/j.cell.2011.02.013
  contributor:
    fullname: Hanahan, D
– year: 1000
  ident: 000334337800011.40
  publication-title: NUCL ACIDS S SER
– volume: 49
  start-page: 4698
  year: 2006
  ident: WOS:000239141500029
  article-title: Exploration of a new type of antimalarial compounds based on febrifugine
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  doi: 10.1021/jm0601809
  contributor:
    fullname: Kikuchi, H
– volume: 24
  start-page: 821
  year: 1987
  ident: WOS:A1987H627300054
  article-title: 9-DEAZAPURINE NUCLEOSIDES - THE SYNTHESIS OF CERTAIN N-5-2'-DEOXY-BETA-D-ERYTHROPENTOFURANOSYL AND N-5-BETA-D-ARABINOFURANOSYLPYRROLO[3,2-D]PYRIMIDINES
  publication-title: JOURNAL OF HETEROCYCLIC CHEMISTRY
  contributor:
    fullname: GIRGIS, NS
– volume: 64
  start-page: 10791
  year: 2008
  ident: WOS:000260703200002
  article-title: Mechanistic studies in the synthesis of a series of thieno-expanded xanthosine and guanosine nucleosides
  publication-title: TETRAHEDRON
  contributor:
    fullname: Zhang, ZB
– volume: 97
  start-page: 695
  year: 1953
  ident: WOS:A1953UD35500008
  article-title: STUDIES ON THE PROPAGATION INVITRO OF POLIOMYELITIS VIRUSES .4. VIRAL MULTIPLICATION IN A STABLE STRAIN OF HUMAN MALIGNANT EPITHELIAL CELLS (STRAIN HELA) DERIVED FROM AN EPIDERMOID CARCINOMA OF THE CERVIX
  publication-title: JOURNAL OF EXPERIMENTAL MEDICINE
  contributor:
    fullname: SCHERER, WF
– volume: 13
  start-page: 883
  year: 1994
  ident: WOS:A1994NL49000001
  article-title: SYNTHESIS OF ACYCLIC THIENO[3,2-D]PYRIMIDINE NUCLEOSIDES AND AZIDO DERIVATIVES AS POTENTIAL ANTI-HIV AGENTS
  publication-title: NUCLEOSIDES & NUCLEOTIDES
  contributor:
    fullname: FOSSEY, C
– start-page: 837
  year: 1974
  ident: WOS:A1974V163200001
  article-title: SURVEY OF METHODS FOR PREPARATION OF PYRROLOPYRIMIDINES
  publication-title: SYNTHESIS-STUTTGART
  contributor:
    fullname: AMARNATH, V
– volume: 22
  start-page: 25
  year: 1981
  ident: WOS:A1981KX03600007
  article-title: SYNTHESIS OF 9-DEAZAADENOSINE - A NEW CYTO-TOXIC C-NUCLEOSIDE ISOSTERE OF ADENOSINE
  publication-title: TETRAHEDRON LETTERS
  contributor:
    fullname: LIM, MI
– volume: 12
  start-page: 4466
  year: 2010
  ident: WOS:000282604700009
  article-title: Tricyclic 2 '-C-Modified Nucleosides as Potential Anti-HCV Therapeutics
  publication-title: ORGANIC LETTERS
  doi: 10.1021/ol101482h
  contributor:
    fullname: Wauchope, OR
– volume: 54
  start-page: 7579
  year: 2011
  ident: WOS:000296408100014
  article-title: Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  doi: 10.1021/jm2009327
  contributor:
    fullname: Sutherlin, DP
– volume: 41
  start-page: 4021
  year: 1998
  ident: WOS:000076374300013
  article-title: Design, synthesis, and biological activities of new thieno[3,2-d]pyrimidines as selective type 4 phosphodiesterase inhibitors
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  contributor:
    fullname: Crespo, MI
– volume: 10
  start-page: 2426
  year: 2011
  ident: WOS:000298344400021
  article-title: GDC-0980 Is a Novel Class I PI3K/mTOR Kinase Inhibitor with Robust Activity in Cancer Models Driven by the PI3K Pathway
  publication-title: MOLECULAR CANCER THERAPEUTICS
  doi: 10.1158/1535-7163.MCT-11-0446
  contributor:
    fullname: Wallin, JJ
– volume: 31
  start-page: 1786
  year: 1988
  ident: WOS:A1988P883100019
  article-title: THIOPHENE SYSTEMS .9. THIENOPYRIMIDINEDIONE DERIVATIVES AS POTENTIAL ANTIHYPERTENSIVE AGENTS
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  contributor:
    fullname: RUSSELL, RK
– volume: 16
  start-page: 87
  year: 2009
  ident: WOS:000261693600011
  article-title: Control of autophagy by oncogenes and tumor suppressor genes
  publication-title: CELL DEATH AND DIFFERENTIATION
  doi: 10.1038/cdd.2008.131
  contributor:
    fullname: Maiuri, MC
– volume: 1
  start-page: 244
  year: 2008
  ident: MEDLINE:20021437
  article-title: Pharmacological inhibition of the Bcl-2 family of apoptosis regulators as cancer therapy.
  publication-title: Current molecular pharmacology
  contributor:
    fullname: Richardson, Alan
– volume: 332
  start-page: 335
  year: 2013
  ident: WOS:000318378200025
  article-title: Targeting apoptosis pathways in glioblastoma
  publication-title: CANCER LETTERS
  doi: 10.1016/j.canlet.2010.12.012
  contributor:
    fullname: Eisele, G
– volume: 184
  start-page: 39
  year: 1995
  ident: WOS:A1995RL33700005
  article-title: A NOVEL ASSAY FOR APOPTOSIS - FLOW CYTOMETRIC DETECTION OF PHOSPHATIDYLSERINE EXPRESSION ON EARLY APOPTOTIC CELLS USING FLUORESCEIN-LABELED ANNEXIN-V
  publication-title: JOURNAL OF IMMUNOLOGICAL METHODS
  contributor:
    fullname: VERMES, I
– volume: 53
  start-page: 1086
  year: 2010
  ident: WOS:000274270900016
  article-title: Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  doi: 10.1021/jm901284w
  contributor:
    fullname: Sutherlin, DP
– volume: 131
  start-page: 18139
  year: 2009
  ident: WOS:000273615400037
  article-title: Thermodynamic Analysis of mRNA Cap Binding by the Human Initiation Factor eIF4E via Free Energy Perturbations
  publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
  doi: 10.1021/ja9064359
  contributor:
    fullname: Guimaraes, CRW
– volume: 10
  start-page: ARTN 35
  year: 2011
  ident: WOS:000289941600001
  article-title: Impacting tumor cell-fate by targeting the inhibitor of apoptosis protein survivin
  publication-title: MOLECULAR CANCER
  doi: 10.1186/1476-4598-10-35
  contributor:
    fullname: Kelly, RJ
– volume: 10
  start-page: 179
  year: 1949
  ident: WOS:A1949UF24900018
  article-title: OBSERVATIONS ON THE EFFECT OF A FOLIC-ACID ANTAGONIST ON TRANSPLANTABLE LYMPHOID LEUKEMIAS IN MICE
  publication-title: JOURNAL OF THE NATIONAL CANCER INSTITUTE
  contributor:
    fullname: LAW, LW
– volume: 38
  start-page: 2763
  year: 1995
  ident: WOS:A1995RJ01400027
  article-title: REVERSIBLE INHIBITORS OF THE GASTRIC (H+/K+)-ATPASE .5. SUBSTITUTED 2,4-DIAMINOQUINAZOLINES AND THIENOPYRIMIDINES
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  contributor:
    fullname: IFE, RJ
– year: 1000
  ident: 000334337800011.1
  publication-title: PERF STAND ANT SUSC
– volume: 13
  start-page: 1641
  year: 2005
  ident: WOS:000227251300024
  article-title: Synthesis and anti-viral activity of a series of D- and L-2 '-deoxy-2 '-fluororibonucleosides in the subgenomic HCV replicon system
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY
  doi: 10.1016/j.bmc.2004.12.011
  contributor:
    fullname: Shi, JX
– volume: 63
  start-page: 3608
  year: 2007
  ident: WOS:000248294800021
  article-title: Designing new isomorphic fluorescent nucleobase analogues: the thieno[3,2-d]pyrimidine core
  publication-title: TETRAHEDRON
  doi: 10.1016/j.tet.2007.01.075
  contributor:
    fullname: Tor, Y
– volume: 78
  start-page: 7305
  year: 2013
  ident: WOS:000322210700051
  article-title: Synthesis of 2 '-Deoxy-9-deaza Nucleosides Using Heck Methodology
  publication-title: JOURNAL OF ORGANIC CHEMISTRY
  doi: 10.1021/jo400913k
  contributor:
    fullname: Temburnikar, K
– volume: 31
  start-page: 319
  year: 2012
  ident: WOS:000303579100004
  article-title: MODIFIED SYNTHESIS OF 3 '-OTBDPS-PROTECTED FURANOID GLYCAL
  publication-title: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
  doi: 10.1080/15257770.2012.656212
  contributor:
    fullname: Temburnikar, K
– year: 1000
  ident: 000334337800011.51
  publication-title: ORGANIC CHEM
– volume: 23
  start-page: 1757
  year: 1986
  ident: WOS:A1986F587500031
  article-title: CONVENIENT SYNTHESIS OF SUBSTITUTED 3-AMINOTHIOPHENE-2-CARBONITRILES FROM ALPHA-ACETYLENIC NITRILES AND THEIR CONVERSION TO THIENO[3,2-D]PYRIMIDINES
  publication-title: JOURNAL OF HETEROCYCLIC CHEMISTRY
  contributor:
    fullname: REN, WY
– volume: 42
  start-page: 5464
  year: 1999
  ident: WOS:000084640000015
  article-title: Tyrosine kinase inhibitors. 16. 6,5,6-tricyclic benzothieno[3,2-d]pyrimidines and pyrimido[5,4-b]- and -[4,5-b]indoles as potent inhibitors of the epidermal growth factor receptor tyrosine kinase
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  contributor:
    fullname: Showalter, HDH
– volume: Fourth
  year: 2000
  ident: 000334337800011.19
  publication-title: Heterocyclic Chemistry
  contributor:
    fullname: Joule, J. A.
– volume: 5
  start-page: 285
  year: 2005
  ident: WOS:000228091000014
  article-title: Chemical approaches to the discovery and development of cancer therapies
  publication-title: NATURE REVIEWS CANCER
  doi: 10.1038/nrc1587
  contributor:
    fullname: Neidle, S
– year: 2002
  ident: 000334337800011.4
  publication-title: MOL BASIS HUMAN CANC
– volume: 21
  start-page: 1013
  year: 1980
  ident: WOS:A1980JH42000007
  article-title: SYNTHESIS OF THE PYRROLO[3,2-D]PYRIMIDINE C-NUCLEOSIDE ISOSTERE OF INOSINE
  publication-title: TETRAHEDRON LETTERS
  contributor:
    fullname: LIM, MI
– volume: 18
  start-page: 522
  year: 1965
  ident: WOS:A19656307400016
  article-title: CONTINUOUS CULTURE OF HUMAN LYMPHOBLASTS FROM PERIPHERAL BLOOD OF A CHILD WITH ACUTE LEUKEMIA
  publication-title: CANCER
  contributor:
    fullname: FOLEY, GE
– volume: 23
  start-page: 1441
  year: 2004
  ident: WOS:000225113700069
  article-title: Selective transport of a new class of purine antimetabolites by the protozoan parasite Trypanosoma brucei
  publication-title: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
  doi: 10.1081/NCN-200027660
  contributor:
    fullname: Wallace, LJM
– volume: 55
  start-page: 5887
  year: 2012
  ident: WOS:000305769600018
  article-title: Discovery of Novel PI3-Kinase delta Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  doi: 10.1021/jm3003747
  contributor:
    fullname: Safina, BS
– volume: 14
  start-page: 6847
  year: 2006
  ident: WOS:000241227400006
  article-title: Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110 alpha inhibitors
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY
  doi: 10.1016/j.bmc.2006.06.046
  contributor:
    fullname: Hayakawa, M
– volume: 26
  start-page: 1289
  year: 2006
  ident: WOS:000236674800063
  article-title: Effects of PRIMA-1 on wild-type L1210 cells expressing mutant p53 and drug-resistant L1210 cells lacking expression of p53: Necrosis vs. apoptosis
  publication-title: ANTICANCER RESEARCH
  contributor:
    fullname: Cory, AH
– volume: 14
  start-page: 21
  year: 2004
  ident: WOS:000187862000001
  article-title: Design and SAR of thienopyrimidine and thienopyridine inhibitors of VEGFR-2 kinase activity
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  doi: 10.1016/j.bmcl.2003.10.030
  contributor:
    fullname: Munchhof, MJ
– volume: 2
  start-page: 907
  year: 2011
  ident: WOS:000297947000007
  article-title: Design, Synthesis, and Biological Evaluation of a Series of Novel AXL Kinase Inhibitors
  publication-title: ACS MEDICINAL CHEMISTRY LETTERS
  doi: 10.1021/ml200198x
  contributor:
    fullname: Mollard, A
– volume: 43
  start-page: 4877
  year: 2000
  ident: WOS:000165866100017
  article-title: Synthesis and antitumor activity of thieno-separated tricyclic purines
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  doi: 10.1021/jm000326i
  contributor:
    fullname: Seley, KL
– volume: 46
  start-page: 277
  year: 2009
  ident: WOS:000266095900005
  article-title: A novel L1 retrotransposon marker for HeLa cell line identification
  publication-title: BIOTECHNIQUES
  doi: 10.2144/000113089
  contributor:
    fullname: Rahbari, R
– volume: 2
  start-page: 19
  ident: MEDLINE:12415616
  article-title: Augmentation of apoptosis by the combination of bleomycin with trifluoperazine in the presence of mutant p53.
  publication-title: Journal of experimental therapeutics & oncology
  contributor:
    fullname: Sullivan, Gregory F
– year: 1000
  ident: 000334337800011.23
  publication-title: FOYES PRINCIPLES MED
– volume: 13
  start-page: 925
  year: 1994
  ident: WOS:A1994NL49000005
  article-title: SYNTHESIS OF N-1-BETA-D-ARABINOFURANOSYL AND N-1-2'-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSYL THIENO[3,2-D]PYRIMIDINE NUCLEOSIDES
  publication-title: NUCLEOSIDES & NUCLEOTIDES
  contributor:
    fullname: FOSSEY, C
– volume: 48
  start-page: 1060
  year: 1983
  ident: WOS:A1983QK09500026
  article-title: SYNTHETIC STRATEGIES TOWARD THE SYNTHESIS OF 2,4-DIMETHOXYPYRROLO[3,2-D]PYRIMIDINE
  publication-title: JOURNAL OF ORGANIC CHEMISTRY
  contributor:
    fullname: CUPPS, TL
– volume: 48
  start-page: 780
  year: 1983
  ident: WOS:A1983QH60600005
  article-title: SYNTHESIS OF 9-DEAZAGUANOSINE AND OTHER NEW PYRROLO[3,2-D]PYRIMIDINE C-NUCLEOSIDES
  publication-title: JOURNAL OF ORGANIC CHEMISTRY
  contributor:
    fullname: LIM, MI
– volume: 47
  start-page: 4633
  year: 1982
  ident: WOS:A1982PR58400005
  article-title: SYNTHETIC STUDIES OF THE THIENO[3,2-D]PYRIMIDINE C-NUCLEOSIDE ISOSTERE OF INOSINE
  publication-title: JOURNAL OF ORGANIC CHEMISTRY
  contributor:
    fullname: REN, WY
– volume: 2
  start-page: 154
  year: 2011
  ident: WOS:000287297200012
  article-title: Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D
  publication-title: ACS MEDICINAL CHEMISTRY LETTERS
  doi: 10.1021/ml100230n
  contributor:
    fullname: Bravo-Altamirano, K
– volume: 55
  start-page: 2869
  year: 2012
  ident: WOS:000301767000029
  article-title: Potent and Selective Aminopyrimidine-Based B-Raf Inhibitors with Favorable Physicochemical and Pharmacokinetic Properties
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  doi: 10.1021/jm300016v
  contributor:
    fullname: Mathieu, S
– volume: 332
  start-page: 359
  year: 2013
  ident: WOS:000318378200027
  article-title: Targeting apoptosis pathways in lung cancer
  publication-title: CANCER LETTERS
  doi: 10.1016/j.canlet.2010.09.012
  contributor:
    fullname: Pore, MM
– volume: 51
  start-page: 5522
  year: 2008
  ident: WOS:000259342700007
  article-title: The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  doi: 10.1021/jm800295d
  contributor:
    fullname: Folkes, AJ
– volume: 332
  start-page: 359
  year: 2013
  ident: 10.1016/j.bmc.2014.02.033_b0265
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2010.09.012
  contributor:
    fullname: Pore
– volume: 97
  start-page: 695
  year: 1953
  ident: 10.1016/j.bmc.2014.02.033_b0200
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.97.5.695
  contributor:
    fullname: Scherer
– volume: 5
  start-page: 285
  year: 2005
  ident: 10.1016/j.bmc.2014.02.033_b0225
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc1587
  contributor:
    fullname: Neidle
– volume: 24
  start-page: 821
  year: 1987
  ident: 10.1016/j.bmc.2014.02.033_b0185
  publication-title: J. Heterocycl. Chem.
  doi: 10.1002/jhet.5570240354
  contributor:
    fullname: Girgis
– volume: 2
  start-page: 19
  year: 2002
  ident: 10.1016/j.bmc.2014.02.033_b0245
  publication-title: J. Exp. Ther. Oncol.
  doi: 10.1046/j.1359-4117.2002.01002.x
  contributor:
    fullname: Sullivan
– volume: 48
  start-page: 780
  year: 1983
  ident: 10.1016/j.bmc.2014.02.033_b0025
  publication-title: J. Org. Chem.
  doi: 10.1021/jo00154a005
  contributor:
    fullname: Lim
– volume: 21
  start-page: 1013
  year: 1980
  ident: 10.1016/j.bmc.2014.02.033_b0010
  publication-title: Tetrahedron Lett.
  doi: 10.1016/S0040-4039(00)78826-5
  contributor:
    fullname: Lim
– ident: 10.1016/j.bmc.2014.02.033_b0280
– volume: 23
  start-page: 1757
  year: 1986
  ident: 10.1016/j.bmc.2014.02.033_b0030
  publication-title: J. Heterocycl. Chem.
  doi: 10.1002/jhet.5570230631
  contributor:
    fullname: Ren
– ident: 10.1016/j.bmc.2014.02.033_b0220
– volume: 26
  start-page: 1289
  year: 2006
  ident: 10.1016/j.bmc.2014.02.033_b0240
  publication-title: Anticancer Res.
  contributor:
    fullname: Cory
– volume: 31
  start-page: 319
  year: 2012
  ident: 10.1016/j.bmc.2014.02.033_b0145
  publication-title: Nucleosides, Nucleotides, Nucleic Acids
  doi: 10.1080/15257770.2012.656212
  contributor:
    fullname: Temburnikar
– volume: 22
  start-page: 25
  year: 1981
  ident: 10.1016/j.bmc.2014.02.033_b0020
  publication-title: Tetrahedron Lett.
  doi: 10.1016/0040-4039(81)80031-7
  contributor:
    fullname: Lim
– volume: 42
  start-page: 5464
  year: 1999
  ident: 10.1016/j.bmc.2014.02.033_b0050
  publication-title: J. Med. Chem.
  doi: 10.1021/jm9903949
  contributor:
    fullname: Showalter
– volume: 1
  start-page: 244
  year: 2008
  ident: 10.1016/j.bmc.2014.02.033_b0270
  publication-title: Curr. Mol. Pharmacol.
  doi: 10.2174/1874467210801030244
  contributor:
    fullname: Richardson
– volume: 16
  start-page: 87
  year: 2009
  ident: 10.1016/j.bmc.2014.02.033_b0235
  publication-title: Cell Death Differ.
  doi: 10.1038/cdd.2008.131
  contributor:
    fullname: Maiuri
– volume: 184
  start-page: 39
  year: 1995
  ident: 10.1016/j.bmc.2014.02.033_b0275
  publication-title: J. Immunol. Methods
  doi: 10.1016/0022-1759(95)00072-I
  contributor:
    fullname: Vermes
– volume: 31
  start-page: 1786
  year: 1988
  ident: 10.1016/j.bmc.2014.02.033_b0035
  publication-title: J. Med. Chem.
  doi: 10.1021/jm00117a019
  contributor:
    fullname: Russell
– volume: 63
  start-page: 3608
  year: 2007
  ident: 10.1016/j.bmc.2014.02.033_b0115
  publication-title: Tetrahedron
  doi: 10.1016/j.tet.2007.01.075
  contributor:
    fullname: Tor
– volume: 144
  start-page: 646
  year: 2011
  ident: 10.1016/j.bmc.2014.02.033_b0250
  publication-title: Cell
  doi: 10.1016/j.cell.2011.02.013
  contributor:
    fullname: Hanahan
– year: 2009
  ident: 10.1016/j.bmc.2014.02.033_b0150
  contributor:
    fullname: Bourke
– volume: 13
  start-page: 883
  year: 1994
  ident: 10.1016/j.bmc.2014.02.033_b0105
  article-title: Nucleosides
  publication-title: Nucleotides Nucleic Acids
  doi: 10.1080/15257779408011862
  contributor:
    fullname: Fossey
– volume: 14
  start-page: 6847
  year: 2006
  ident: 10.1016/j.bmc.2014.02.033_b0070
  publication-title: Bioorg. Med. Chem.
  doi: 10.1016/j.bmc.2006.06.046
  contributor:
    fullname: Hayakawa
– volume: 18
  start-page: 522
  year: 1965
  ident: 10.1016/j.bmc.2014.02.033_b0195
  publication-title: Cancer
  doi: 10.1002/1097-0142(196504)18:4<522::AID-CNCR2820180418>3.0.CO;2-J
  contributor:
    fullname: Foley
– volume: 43
  start-page: 4877
  year: 2000
  ident: 10.1016/j.bmc.2014.02.033_b0055
  publication-title: J. Med. Chem.
  doi: 10.1021/jm000326i
  contributor:
    fullname: Seley
– volume: 10
  start-page: 2426
  year: 2011
  ident: 10.1016/j.bmc.2014.02.033_b0090
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-11-0446
  contributor:
    fullname: Wallin
– volume: 48
  start-page: 1060
  year: 1983
  ident: 10.1016/j.bmc.2014.02.033_b0170
  publication-title: J. Org. Chem.
  doi: 10.1021/jo00155a026
  contributor:
    fullname: Cupps
– volume: 55
  start-page: 2869
  year: 2012
  ident: 10.1016/j.bmc.2014.02.033_b0095
  publication-title: J. Med. Chem.
  doi: 10.1021/jm300016v
  contributor:
    fullname: Mathieu
– volume: 10
  start-page: 35
  year: 2011
  ident: 10.1016/j.bmc.2014.02.033_b0255
  publication-title: Mol. Cancer
  doi: 10.1186/1476-4598-10-35
  contributor:
    fullname: Kelly
– volume: 41
  start-page: 4021
  year: 1998
  ident: 10.1016/j.bmc.2014.02.033_b0045
  publication-title: J. Med. Chem.
  doi: 10.1021/jm981012m
  contributor:
    fullname: Crespo
– volume: 78
  start-page: 7305
  year: 2013
  ident: 10.1016/j.bmc.2014.02.033_b0140
  publication-title: J. Org. Chem.
  doi: 10.1021/jo400913k
  contributor:
    fullname: Temburnikar
– volume: 131
  start-page: 18139
  year: 2009
  ident: 10.1016/j.bmc.2014.02.033_b0180
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja9064359
  contributor:
    fullname: Guimaraes
– volume: 47
  start-page: 4633
  year: 1982
  ident: 10.1016/j.bmc.2014.02.033_b0015
  publication-title: J. Org. Chem.
  doi: 10.1021/jo00145a005
  contributor:
    fullname: Ren
– volume: 12
  start-page: 4466
  year: 2010
  ident: 10.1016/j.bmc.2014.02.033_b0130
  publication-title: Org. Lett.
  doi: 10.1021/ol101482h
  contributor:
    fullname: Wauchope
– volume: 332
  start-page: 335
  year: 2013
  ident: 10.1016/j.bmc.2014.02.033_b0260
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2010.12.012
  contributor:
    fullname: Eisele
– volume: 38
  start-page: 2763
  year: 1995
  ident: 10.1016/j.bmc.2014.02.033_b0040
  publication-title: J. Med. Chem.
  doi: 10.1021/jm00014a027
  contributor:
    fullname: Ife
– volume: 53
  start-page: 1086
  year: 2010
  ident: 10.1016/j.bmc.2014.02.033_b0080
  publication-title: J. Med. Chem.
  doi: 10.1021/jm901284w
  contributor:
    fullname: Sutherlin
– volume: 10
  start-page: 179
  year: 1949
  ident: 10.1016/j.bmc.2014.02.033_b0190
  publication-title: J. Natl. Cancer. Inst.
  contributor:
    fullname: Law
– year: 2002
  ident: 10.1016/j.bmc.2014.02.033_b0230
– ident: 10.1016/j.bmc.2014.02.033_b0215
– volume: 55
  start-page: 5887
  year: 2012
  ident: 10.1016/j.bmc.2014.02.033_b0100
  publication-title: J. Med. Chem.
  doi: 10.1021/jm3003747
  contributor:
    fullname: Safina
– volume: 54
  start-page: 7579
  year: 2011
  ident: 10.1016/j.bmc.2014.02.033_b0085
  publication-title: J. Med. Chem.
  doi: 10.1021/jm2009327
  contributor:
    fullname: Sutherlin
– start-page: 837
  year: 1974
  ident: 10.1016/j.bmc.2014.02.033_b0005
  publication-title: Synthesis
  doi: 10.1055/s-1974-23448
  contributor:
    fullname: Amarnath
– volume: 51
  start-page: 5522
  year: 2008
  ident: 10.1016/j.bmc.2014.02.033_b0075
  publication-title: J. Med. Chem.
  doi: 10.1021/jm800295d
  contributor:
    fullname: Folkes
– volume: 66
  start-page: 5723
  year: 2001
  ident: 10.1016/j.bmc.2014.02.033_b0175
  publication-title: J. Org. Chem.
  doi: 10.1021/jo0155613
  contributor:
    fullname: Evans
– ident: 10.1016/j.bmc.2014.02.033_b0205
  doi: 10.2144/000113089
– volume: 64
  start-page: 10791
  year: 2008
  ident: 10.1016/j.bmc.2014.02.033_b0125
  publication-title: Tetrahedron
  doi: 10.1016/j.tet.2008.09.011
  contributor:
    fullname: Zhang
– volume: 2
  start-page: 907
  year: 2011
  ident: 10.1016/j.bmc.2014.02.033_b0210
  publication-title: ACS Med. Chem. Lett.
  doi: 10.1021/ml200198x
  contributor:
    fullname: Mollard
– volume: 2
  start-page: 154
  year: 2011
  ident: 10.1016/j.bmc.2014.02.033_b0155
  publication-title: ACS Med. Chem. Lett.
  doi: 10.1021/ml100230n
  contributor:
    fullname: Bravo-Altamirano
– ident: 10.1016/j.bmc.2014.02.033_b0165
– volume: 14
  start-page: 21
  year: 2004
  ident: 10.1016/j.bmc.2014.02.033_b0060
  publication-title: Bioorg. Med. Chem. Lett.
  doi: 10.1016/j.bmcl.2003.10.030
  contributor:
    fullname: Munchhof
– volume: 52
  start-page: 635
  year: 2008
  ident: 10.1016/j.bmc.2014.02.033_b0120
  publication-title: Nucleic Acids Symp. Ser.
  doi: 10.1093/nass/nrn321
  contributor:
    fullname: Seley-Radtke
– volume: 13
  start-page: 925
  year: 1994
  ident: 10.1016/j.bmc.2014.02.033_b0110
  article-title: Nucleosides
  publication-title: Nucleotides Nucleic Acids
  doi: 10.1080/15257779408011866
  contributor:
    fullname: Fossey
– volume: 49
  start-page: 4698
  year: 2006
  ident: 10.1016/j.bmc.2014.02.033_b0065
  publication-title: J. Med. Chem.
  doi: 10.1021/jm0601809
  contributor:
    fullname: Kikuchi
– volume: 23
  start-page: 1441
  year: 2004
  ident: 10.1016/j.bmc.2014.02.033_b0135
  article-title: Nucleosides
  publication-title: Nucleotides Nucleic Acids
  doi: 10.1081/NCN-200027660
  contributor:
    fullname: Wallace
– volume: 13
  start-page: 1641
  year: 2005
  ident: 10.1016/j.bmc.2014.02.033_b0160
  publication-title: Bioorg. Med. Chem.
  doi: 10.1016/j.bmc.2004.12.011
  contributor:
    fullname: Shi
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Snippet The in vitro evaluation of thieno[3,2-d]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer...
The in vitro evaluation of thieno[3,2- d ]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer...
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SubjectTerms Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antifungal
Antifungal Agents - chemical synthesis
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Apoptosis
Apoptosis - drug effects
Bacillus subtilis - drug effects
Biochemistry & Molecular Biology
Cell Cycle - drug effects
Cell Proliferation - drug effects
Chemistry
Chemistry, Medicinal
Chemistry, Organic
Cytostatic
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Fungi - drug effects
Heterocyclic chemistry
Humans
Life Sciences & Biomedicine
Microbial Sensitivity Tests
Molecular Structure
Pharmacology & Pharmacy
Physical Sciences
Pyrimidines - chemical synthesis
Pyrimidines - chemistry
Pyrimidines - pharmacology
Science & Technology
Structure-Activity Relationship
Thieno[3,2-d]pyrimidine
Tumor Cells, Cultured
Title Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines
URI https://dx.doi.org/10.1016/j.bmc.2014.02.033
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https://pubmed.ncbi.nlm.nih.gov/PMC4565497
Volume 22
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