Intracrine androgen biosynthesis, metabolism and action revisited

• Published in: Molecular and cellular endocrinology Vol. 465; pp. 4 - 26
• Main Authors: Schiffer, Lina, Arlt, Wiebke, Storbeck, Karl-Heinz
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 15.04.2018; North Holland Publishing
• Subjects: 11-oxygenated androgens; androgen receptors; Androgens; Androgens - biosynthesis; Androgens - metabolism; Animals; biosynthesis; Biosynthetic Pathways; excretion; homeostasis; Hormone-dependent cancer; Humans; Intracrinology; kidneys; liver; men; metabolites; Organ Specificity; Reproduction; Steroid biosynthesis; Steroids - biosynthesis; Testosterone; women; DHEA; PREG; UGT; E1S; 17αHP; 11-oxygenated androgens; E1; E2; SULT; DHT; PAPS; A4; DHEAS; STS; PORD; T; StAR; 3α-adiol; HSD; CYP; CHOL; 11KT; 11OHDHT; 5-diol; 17OHPROG; AST; Pdiol; AKR; OATP; 5α-dione; Steroid biosynthesis; Hormone-dependent cancer; Testosterone; AR; Androgens; 11OHT; PCOS; ETIO; Intracrinology; 11KDHT; 11KA4; EpiT; 11OHA4; SHBG; CRPC; EpiAST; PROG

Androgens play an important role in metabolic homeostasis and reproductive health in both men and women. Androgen signalling is dependent on androgen receptor activation, mostly by testosterone and 5α-dihydrotestosterone. However, the intracellular or intracrine activation of C19 androgen precursors...