Dietary predictors of the insulin-like growth factor system in adolescent females: results from the Dietary Intervention Study in Children (DISC)

• Published in: The American journal of clinical nutrition Vol. 91; no. 3; pp. 643 - 650
• Main Authors: Kerver, Jean M, Gardiner, Joseph C, Dorgan, Joanne F, Rosen, Cliff J, Velie, Ellen M
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Clinical Nutrition 01.03.2010; American Society for Nutrition; American Society for Clinical Nutrition, Inc
• Subjects: Adolescent; adolescents; Biological and medical sciences; Biomarkers; Biomarkers - blood; blood serum; Body Mass Index; Calcium; Calcium, Dietary - administration & dosage; Children & youth; chronic diseases; Diet; diet recall; Diet Records; Dietary Intervention Study in Children; Dietary Proteins - administration & dosage; Feeding. Feeding behavior; Female; food intake; Fundamental and applied biological sciences. Psychology; girls; Humans; Insulin-Like Growth Factor Binding Protein 1 - blood; Insulin-Like Growth Factor Binding Protein 3 - blood; insulin-like growth factor binding proteins; insulin-like growth factor I; Insulin-Like Growth Factor I - metabolism; Linear Models; Multivariate analysis; nutrient intake; Nutrition; Plant Proteins - administration & dosage; prediction; Proteins; radioimmunoassays; Vegetables; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Human; Female; Insulin like growth factor; Child; Adolescent
• ISSN: 0002-9165; 1938-3207
• DOI: 10.3945/ajcn.2009.28205

BACKGROUND: The insulin-like growth factor (IGF) system is associated with the adult diet and chronic disease. Childhood diet may influence chronic disease through its effect on the IGF system; however, there is limited information describing the dietary predictors of the IGF system in adolescents. OBJECTIVE: We examined associations between dietary food intake [fat, protein (animal and vegetable), carbohydrate, lactose, dietary fiber, calcium, zinc, and sodium] and serum IGF-I, IGF binding protein 1 (IGFBP-1), IGF binding protein 3 (IGFBP-3), and the IGF-I:IGFBP-3 molar ratio in adolescent females. DESIGN: One hundred fifty-nine adolescent females in the Dietary Intervention Study in Children (age range: 14-18 y; 0.2-6.3 y postmenarche) were included. The dietary intake was assessed via three 24-h dietary recalls. IGF-related biomarkers were determined by using radioimmunoassays. Associations between dietary intakes and biomarkers were assessed with Pearson's correlations and multivariable linear regression. Dietary intakes and biomarkers were logarithmically transformed; thus, β coefficients represented percentages. RESULTS: In analyses adjusted for energy, age, and time since menarche, significant correlations (P < 0.05) were as follows: IGF-I with total protein, lactose, calcium, and sodium; IGFBP-3 with total fat (inverse), lactose, fiber, and calcium; IGF-I/IGFBP-3 with lactose and calcium; and IGFBP-1 with vegetable protein. In multivariable analyses, significant predictors of IGF-I were energy (β = 0.14, P < 0.05) and calcium (β = 0.14, P < 0.01), the significant predictor of IGFBP-3 was calcium (β = 0.07, P < 0.05), and significant predictors of IGFBP-1 were vegetable protein (β = 0.49, P < 0.05) and body mass index-for-age percentile (β = -0.01, P < 0.001). CONCLUSION: This study provides evidence that dietary intake affects IGF-related biomarkers--particularly elevated calcium with IGF-I and IGFBP-3 and elevated vegetable protein with IGFBP-1--and, to our knowledge, is novel in reporting these associations in adolescent females. The Dietary Intervention Study in Children was registered at clinicaltrials.gov as NCT00000459.