Irisin modulates genes associated with severe coronavirus disease (COVID-19) outcome in human subcutaneous adipocytes cell culture

• Published in: Molecular and cellular endocrinology Vol. 515; p. 110917
• Main Authors: de Oliveira, Miriane, De Sibio, Maria Teresa, Mathias, Lucas Solla, Rodrigues, Bruna Moretto, Sakalem, Marna Eliana, Nogueira, Célia Regina
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 15.09.2020
• Subjects: ADAM10; ADAM10 Protein - genetics; ADAM10 Protein - metabolism; adipocytes; Adipocytes - cytology; Adipocytes - drug effects; Adipocytes - metabolism; Adipose tissue; Amyloid Precursor Protein Secretases - genetics; Amyloid Precursor Protein Secretases - metabolism; Angiotensin-Converting Enzyme 2; Betacoronavirus - genetics; Betacoronavirus - metabolism; cell culture; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cells, Cultured; Coronavirus Infections - virology; COVID-19; COVID-19 infection; endocrinology; Fibronectins - genetics; Fibronectins - metabolism; Fibronectins - pharmacology; FURIN; Furin - genetics; Furin - metabolism; Gene Expression Regulation - drug effects; Gene Ontology; Histone Acetyltransferases - genetics; Histone Acetyltransferases - metabolism; Histone Deacetylase 2 - genetics; Histone Deacetylase 2 - metabolism; Humans; Irisin; Jumonji Domain-Containing Histone Demethylases - genetics; Jumonji Domain-Containing Histone Demethylases - metabolism; Membrane Proteins - genetics; Membrane Proteins - metabolism; Models, Biological; Molecular Sequence Annotation; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; obesity; Obesity - virology; Pandemics; peptidyl-dipeptidase A; Peptidyl-Dipeptidase A - genetics; Peptidyl-Dipeptidase A - metabolism; Pneumonia, Viral - virology; Protein Serine-Threonine Kinases - antagonists & inhibitors; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; rab1 GTP-Binding Proteins - genetics; rab1 GTP-Binding Proteins - metabolism; Repressor Proteins - genetics; Repressor Proteins - metabolism; SARS-CoV-2; sequence analysis; Severe acute respiratory syndrome coronavirus 2; Signal Transduction; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; therapeutics; Toll-Like Receptor 3 - genetics; Toll-Like Receptor 3 - metabolism; TRIB3; virus replication; Irisin; ADAM10; SARS-CoV-2; TRIB3; FURIN; Adipose tissue

Obesity patients are more susceptible to develop COVID-19 severe outcome due to the role of angiotensin-converting enzyme 2 (ACE2) in the viral infection. ACE2 is regulated in the human cells by different genes associated with increased (TLR3, HAT1, HDAC2, KDM5B, SIRT1, RAB1A, FURIN and ADAM10) or d...