Relationship Between Blood- and Cerebrospinal Fluid–Bound Neurotransmitter Concentrations and Conditioned Pain Modulation in Pain-Free and Chronic Pain Subjects

• Published in: The journal of pain Vol. 16; no. 5; pp. 436 - 444
• Main Authors: Parent, Alexandre J, Beaudet, Nicolas, Daigle, Kathya, Sabbagh, Robert, Sansoucy, Yanick, Marchand, Serge, Sarret, Philippe, Goffaux, Philippe
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2015
• Subjects: Aged; Anesthesia & Perioperative Care; blood pressure; Chronic Pain - blood; Chronic Pain - cerebrospinal fluid; Descending pain inhibition; Humans; Male; mass spectrometry; Middle Aged; monoamines; Neural Inhibition - physiology; Neural Pathways - physiology; Neurotransmitter Agents - blood; Neurotransmitter Agents - cerebrospinal fluid; Pain Medicine; Pain Perception - physiology; plasma; Transurethral Resection of Prostate; blood pressure; mass spectrometry; plasma; Descending pain inhibition; monoamines

Abstract Descending pain inhibition is an endogenous pain control system thought to depend partially on the activation of bulbospinal monoaminergic pathways. Deficits in descending pain inhibition have been reported in numerous human chronic pain conditions, but there is currently no consensus regar...