Chondroitin sulfate: A key molecule in the brain matrix

Chondroitin sulfate is a glycosaminoglycan composed of N-acetylgalactosamine and glucuronic acid. It attaches to a core protein to form chondroitin sulfate proteoglycan (CSPG). Being a major component of the brain extracellular matrix, CSPGs are involved in neural development, axon pathfinding and g...

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Published inThe international journal of biochemistry & cell biology Vol. 44; no. 4; pp. 582 - 586
Main Authors Kwok, J.C.F., Warren, P., Fawcett, J.W.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.04.2012
Subjects
Animals
binding properties
biochemical pathways
brain
Brain - metabolism
Brain - physiology
Brain Injuries - metabolism
Brain Injuries - physiopathology
Central nervous system
Chondroitin sulfate
Chondroitin Sulfates - biosynthesis
Chondroitin Sulfates - chemistry
Chondroitin Sulfates - metabolism
extracellular matrix
Gene Expression Regulation
glucuronic acid
Humans
neurodevelopment
Neuronal Plasticity
Plasticity
proteoglycans
Regeneration
Spinal Cord Injuries - metabolism
Spinal Cord Injuries - physiopathology
Regeneration
Chondroitin sulfate
Plasticity
Central nervous system
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Abstract Chondroitin sulfate is a glycosaminoglycan composed of N-acetylgalactosamine and glucuronic acid. It attaches to a core protein to form chondroitin sulfate proteoglycan (CSPG). Being a major component of the brain extracellular matrix, CSPGs are involved in neural development, axon pathfinding and guidance, plasticity and also regeneration after injury in the nervous system. In this review, we shall discuss the structure, the biosynthetic pathway, its functions in the nervous system and how we can improve regeneration in the nervous system by modulating its structure and binding properties.
AbstractList Chondroitin sulfate is a glycosaminoglycan composed of N-acetylgalactosamine and glucuronic acid. It attaches to a core protein to form chondroitin sulfate proteoglycan (CSPG). Being a major component of the brain extracellular matrix, CSPGs are involved in neural development, axon pathfinding and guidance, plasticity and also regeneration after injury in the nervous system. In this review, we shall discuss the structure, the biosynthetic pathway, its functions in the nervous system and how we can improve regeneration in the nervous system by modulating its structure and binding properties.
Author Kwok, J.C.F.
Warren, P.
Fawcett, J.W.
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  surname: Warren
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  givenname: J.W.
  surname: Fawcett
  fullname: Fawcett, J.W.
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Keywords Regeneration
Chondroitin sulfate
Plasticity
Central nervous system
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Snippet Chondroitin sulfate is a glycosaminoglycan composed of N-acetylgalactosamine and glucuronic acid. It attaches to a core protein to form chondroitin sulfate...
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SubjectTerms Animals
binding properties
biochemical pathways
brain
Brain - metabolism
Brain - physiology
Brain Injuries - metabolism
Brain Injuries - physiopathology
Central nervous system
Chondroitin sulfate
Chondroitin Sulfates - biosynthesis
Chondroitin Sulfates - chemistry
Chondroitin Sulfates - metabolism
extracellular matrix
Gene Expression Regulation
glucuronic acid
Humans
neurodevelopment
Neuronal Plasticity
Plasticity
proteoglycans
Regeneration
Spinal Cord Injuries - metabolism
Spinal Cord Injuries - physiopathology
Title Chondroitin sulfate: A key molecule in the brain matrix
URI https://dx.doi.org/10.1016/j.biocel.2012.01.004
https://www.ncbi.nlm.nih.gov/pubmed/22265655
https://search.proquest.com/docview/1019649993
https://search.proquest.com/docview/926507261
Volume 44
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