Controlled-release effervescent floating matrix tablets of ciprofloxacin hydrochloride: Development, optimization and in vitro–in vivo evaluation in healthy human volunteers

• Published in: European journal of pharmaceutics and biopharmaceutics Vol. 74; no. 2; pp. 332 - 339
• Main Author: Tadros, Mina Ibrahim
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.02.2010; Elsevier
• Subjects: Abdominal X-ray imaging; Adult; Alginates - chemistry; Alginates - pharmacokinetics; Barium Sulfate - pharmacokinetics; Biological and medical sciences; Calcium Carbonate - chemistry; Chemical Phenomena; Ciprofloxacin - pharmacokinetics; Ciprofloxacin hydrochloride; Contrast Media - pharmacokinetics; Delayed-Action Preparations - administration & dosage; Delayed-Action Preparations - chemical synthesis; Delayed-Action Preparations - chemistry; Delayed-Action Preparations - pharmacokinetics; Drug Compounding - methods; Drug Stability; Floating gastroretentive tablets; Gas former; General pharmacology; Glucuronic Acid - chemistry; Glucuronic Acid - pharmacokinetics; Hexuronic Acids - chemistry; Hexuronic Acids - pharmacokinetics; Humans; Hypromellose Derivatives; Male; Medical sciences; Methylcellulose - analogs & derivatives; Methylcellulose - chemistry; Methylcellulose - pharmacokinetics; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Radiography, Abdominal; Release-retarding polymers; Sodium Bicarbonate - chemistry; Stomach - diagnostic imaging; Stomach - metabolism; Tablets - administration & dosage; Tablets - chemical synthesis; Tablets - chemistry; Tablets - pharmacokinetics; Time Factors; Abdominal X-ray imaging; Gas former; Ciprofloxacin hydrochloride; Release-retarding polymers; Floating gastroretentive tablets; Human; Evaluation; Pharmaceutical technology; Healthy subject; Controlled release form; Polymer; X ray; Effervescent form; In vitro; Matrix tablet; Optimization; In vivo; Fluoroquinolone derivatives; Dosage form; Medical imagery; Antibacterial agent; Ciprofloxacin; Quinolone derivatives; Release

Ciprofloxacin hydrochloride has a short elimination half-life, a narrow absorption window and is mainly absorbed in proximal areas of GIT. The purpose of this study was to develop a gastroretentive controlled-release drug delivery system with swelling, floating, and adhesive properties. Ten tablet f...