Long-Interval Cortical Inhibition from the Dorsolateral Prefrontal Cortex: a TMS–EEG Study

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 33; no. 12; pp. 2860 - 2869
• Main Authors: Daskalakis, Zafiris J, Farzan, Faranak, Barr, Mera S, Maller, Jerome J, Chen, Robert, Fitzgerald, Paul B
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.11.2008; Nature Publishing; Nature Publishing Group
• Subjects: Adult; Behavioral Sciences; Biological and medical sciences; Biological Psychology; Brain Mapping - methods; Electroencephalography; Electroencephalography - methods; Electromyography; Evoked Potentials - physiology; Female; Humans; Male; Medical sciences; Medicine; Medicine & Public Health; Mental disorders; Middle Aged; Motor Cortex - anatomy & histology; Motor Cortex - physiology; Nerve Net - physiology; Neural Inhibition - physiology; Neural Pathways - physiology; Neurons - physiology; Neurosciences; original-article; Pharmacotherapy; Prefrontal Cortex - anatomy & histology; Prefrontal Cortex - physiology; Psychiatry; Reaction Time - physiology; Receptors, GABA-B - metabolism; Synaptic Transmission - physiology; Time Factors; Transcranial magnetic stimulation; Transcranial Magnetic Stimulation - methods; Young Adult; Canada; electroencephalography; motor cortex; receptor; cortical inhibition; GABA; transcranial magnetic stimulation; dorsolateral prefrontal cortex; Dorsolateral prefrontal cortex; Transcranial magnetic stimulation; Motor pathway; Motor cortex; Central nervous system; Electrophysiology; Electroencephalography; Inhibition; GABAR receptor; Encephalon; Biological receptor

Several studies have demonstrated that cortical inhibition (CI) can be recorded by paired transcranial magnetic stimulation (TMS) of the motor cortex and recorded by surface electromyography (EMG). However, recording CI from other cortical regions that are more closely associated with the pathophysi...