Biology of Zika Virus Infection in Human Skin Cells

• Published in: Journal of virology Vol. 89; no. 17; pp. 8880 - 8896
• Main Authors: Hamel, Rodolphe, Dejarnac, Ophélie, Wichit, Sineewanlaya, Ekchariyawat, Peeraya, Neyret, Aymeric, Luplertlop, Natthanej, Perera-Lecoin, Manuel, Surasombatpattana, Pornapat, Talignani, Loïc, Thomas, Frédéric, Cao-Lormeau, Van-Mai, Choumet, Valérie, Briant, Laurence, Desprès, Philippe, Amara, Ali, Yssel, Hans, Missé, Dorothée
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.09.2015
• Subjects: Aedes; Aedes - virology; Animals; Autophagy; Autophagy - immunology; Axl Receptor Tyrosine Kinase; Biochemistry, Molecular Biology; Cell Adhesion Molecules; Cell Adhesion Molecules - genetics; Cell Adhesion Molecules - metabolism; Cells, Cultured; Cellular Biology; Chlorocebus aethiops; Cytokines; Cytokines - biosynthesis; DEAD Box Protein 58; DEAD-Box RNA Helicases; DEAD-box RNA Helicases - genetics; DEAD-box RNA Helicases - metabolism; Dendritic Cells; Dendritic Cells - immunology; Dendritic Cells - virology; Fibroblasts; Fibroblasts - virology; Flaviviridae; Flaviviridae - immunology; Flaviviridae - physiology; Flaviviridae Infections; Flaviviridae Infections - immunology; Flaviviridae Infections - virology; HEK293 Cells; Hepatitis A VIrus Cellular Receptor 1; Humans; Insect Vectors; Insect Vectors - virology; Interferon-beta; Interferon-beta - biosynthesis; Interferon-beta - immunology; Interferon-Induced Helicase, IFIH1; Keratinocytes; Keratinocytes - virology; Lectins, C-Type; Lectins, C-Type - genetics; Lectins, C-Type - metabolism; Life Sciences; Membrane Glycoproteins; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Microbiology and Parasitology; Myxovirus Resistance Proteins; Myxovirus Resistance Proteins - biosynthesis; Phagosomes; Phagosomes - immunology; Proto-Oncogene Proteins; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; Receptor Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases - genetics; Receptor Protein-Tyrosine Kinases - metabolism; Receptors, Cell Surface; Receptors, Cell Surface - genetics; Receptors, Cell Surface - metabolism; Receptors, Immunologic; Receptors, Virus; Receptors, Virus - genetics; Receptors, Virus - metabolism; RNA Interference; RNA, Small Interfering; Skin; Skin - immunology; Skin - virology; Toll-Like Receptor 3; Toll-Like Receptor 3 - genetics; Toll-Like Receptor 3 - immunology; Toll-Like Receptor 3 - metabolism; Toll-Like Receptor 7; Toll-Like Receptor 7 - immunology; Ubiquitins; Ubiquitins - biosynthesis; Vero Cells; Virology; Virus Internalization; Virus Replication; Virus-Cell Interactions

Zika virus (ZIKV) is an emerging arbovirus of the Flaviviridae family, which includes dengue, West Nile, yellow fever, and Japanese encephalitis viruses, that causes a mosquito-borne disease transmitted by the Aedes genus, with recent outbreaks in the South Pacific. Here we examine the importance of...