Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration

• Published in: Journal of cell science Vol. 130; no. 5; pp. 938 - 949
• Main Authors: Bosch Grau, Montserrat, Masson, Christel, Gadadhar, Sudarshan, Rocha, Cecilia, Tort, Olivia, Marques Sousa, Patricia, Vacher, Sophie, Bieche, Ivan, Janke, Carsten
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 01.03.2017; Company of Biologists
• Subjects: Animals; Apoptosis; Axonemes; Cellular Biology; Cilia; Cilia - metabolism; Degeneration; Dismantling; Flagella; Glutamic Acid - metabolism; Glycosylation; Human health and pathology; Life Sciences; Mice, Inbred C57BL; Neuroglia - metabolism; Neuroglia - pathology; Peptide Synthases - metabolism; Phenotype; Photoreception; Photoreceptor Cells, Vertebrate - metabolism; Photoreceptor Cells, Vertebrate - pathology; Photoreceptors; Post-translation; Purkinje Cells - metabolism; Purkinje Cells - pathology; Retina; Retina - metabolism; Retina - pathology; Retinal degeneration; Retinal Degeneration - metabolism; Retinal Degeneration - pathology; Rhodopsin - metabolism; Subcellular Processes; Time Factors; Tubulin; Tubulin - metabolism; Glycylation; Tubulin; TTLL3; Photoreceptor; Retina; Connecting cilia; Microtubule; Glutamylation

Tubulin is subject to a wide variety of posttranslational modifications, which, as part of the tubulin code, are involved in the regulation of microtubule functions. Glycylation has so far predominantly been found in motile cilia and flagella, and absence of this modification leads to ciliary disass...