A hybrid cellular automaton model of clonal evolution in cancer: The emergence of the glycolytic phenotype

• Published in: Journal of theoretical biology Vol. 250; no. 4; pp. 705 - 722
• Main Authors: Gerlee, P., Anderson, A.R.A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 21.02.2008
• Subjects: Anaerobic metabolism; Cell Proliferation; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Cellular automaton; Clonal evolution; Evolutionary dynamics; Extracellular Matrix - metabolism; Extracellular Matrix - pathology; Glycolysis; Humans; Hybrid; Mathematical model; Micro-environment; Models, Biological; Mutation; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Phenotype; Response network; Tumourigenesis; Clonal evolution; Response network; Cellular automaton; Evolutionary dynamics; Hybrid; Glycolysis; Anaerobic metabolism; Mathematical model; Tumourigenesis; Micro-environment

We present a cellular automaton model of clonal evolution in cancer aimed at investigating the emergence of the glycolytic phenotype. In the model each cell is equipped with a micro-environment response network that determines the behaviour or phenotype of the cell based on the local environment. Th...