Impaired intestinal mucosal immunity is associated with the imbalance of T lymphocyte sub-populations in intrauterine growth-restricted neonatal piglets

• Published in: Immunobiology (1979) Vol. 220; no. 6; pp. 775 - 781
• Main Authors: Dong, Li, Zhong, Xiang, Zhang, Lili, Kong, Lingrui, Kong, Yili, Kou, Tao, Wang, Tian
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier GmbH 01.06.2015
• Subjects: Advanced Basic Science; Allergy and Immunology; Animals; Animals, Newborn; Antigens, Surface - metabolism; CD4; CD8; Female; Fetal Growth Retardation; Immunity, Mucosal; Immunohistochemistry; Immunophenotyping; Intestinal Mucosa - immunology; Intestinal Mucosa - metabolism; Intestine; Intestines - immunology; Intestines - metabolism; IUGR; MHC-II; Pregnancy; Spleen - immunology; Spleen - metabolism; Swine; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; IgA; major histocompatibility complex class II; tumor necrosis factor α; IgG; MLN; SD; IFN-γ; mesenteric lymph nodes; Intestine; interferon γ; intrauterine growth restriction; interleukin; normal body weight; standard error means; NBW; immunoglobulin G; IL; T regs; immunoglobulin A; regulatory T cells; CD4; TNF-α; IUGR; CD8; SEM; MHC-II; standard deviation; Tregs

Abstract Intrauterine growth restriction (IUGR) impairs the immunity of both piglets and humans. We hypothesized that the poor cytokine secreting ability of the small intestines of IUGR neonatal piglets might be associated with lower CD4+ and CD8+ T lymphocytes. Therefore, we used neonatal piglets a...