Clozapine Worsens Glucose Intolerance, Nonalcoholic Fatty Liver Disease, Kidney Damage, and Retinal Injury and Increases Renal Reactive Oxygen Species Production and Chromium Loss in Obese Mice

• Published in: International Journal of Molecular Sciences Vol. 22; no. 13; p. 6680
• Main Authors: Chang, Geng-Ruei, Liu, Hsien-Yueh, Yang, Wei-Cheng, Wang, Chao-Min, Wu, Ching-Fen, Lin, Jen-Wei, Lin, Wei-Li, Wang, Yu-Chen, Lin, Tzu-Chun, Liao, Huei-Jyuan, Hou, Po-Hsun, Chan, Chee-Hong, Lin, Chuen-Fu
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 22.06.2021; MDPI
• Subjects: Adipocytes; Animals; Biomarkers; Body Weights and Measures; Chromium; chromium; clozapine; fatty liver disease; glucose intolerance; obesity; renal damage; retinal injury; reactive oxygen species; Clozapine; Diabetes; Disease Models, Animal; Dopamine; Fatty Acid-Binding Proteins; Fatty liver; Fluorescent Antibody Technique; Food; Gene Expression; Gene Expression Regulation; Glucose; Glucose Intolerance; Hyperglycemia; Immunohistochemistry; Insulin; Insulin resistance; Kidney Diseases; Kidneys; Liver; Liver diseases; Metabolism; Mice; Mice, Obese; Nitric Oxide Synthase Type II; Non-alcoholic Fatty Liver Disease; Obesity; Oxidative stress; Proto-Oncogene Proteins c-akt; Psychotropic drugs; Reactive Oxygen Species; Retinal Diseases; Schizophrenia; Serotonin; Sterol Regulatory Element Binding Protein 1

Clozapine is widely employed in the treatment of schizophrenia. Compared with that of atypical first-generation antipsychotics, atypical second-generation antipsychotics such as clozapine have less severe side effects and may positively affect obesity and blood glucose level. However, no systematic...