Chronic REM-sleep deprivation of rats elevates metabolic rate and increases UCP1 gene expression in brown adipose tissue

• Published in: American journal of physiology: endocrinology and metabolism Vol. 289; no. 1; pp. E68 - E74
• Main Authors: Koban, Michael, Swinson, Kevin L
• Format: Journal Article
• Language: English
• Published: United States 01.07.2005
• Subjects: Adipose Tissue, Brown - metabolism; Animals; Carrier Proteins - metabolism; Energy Metabolism; Gene Expression Regulation; Hyperphagia - etiology; Hyperphagia - metabolism; Ion Channels; Membrane Proteins - metabolism; Men; Mitochondrial Proteins; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Sleep Deprivation - complications; Sleep Deprivation - metabolism; Thermogenesis; Uncoupling Protein 1

Laboratory of Physiology, Department of Biology, Morgan State University, Baltimore, Maryland Submitted 11 November 2004 ; accepted in final form 14 February 2005 A cluster of unique pathologies progressively develops during chronic total- or rapid eye movement-sleep deprivation (REM-SD) of rats. Tw...