Development of selective androgen receptor modulators (SARMs)

• Published in: Molecular and cellular endocrinology Vol. 465; pp. 134 - 142
• Main Authors: Narayanan, Ramesh, Coss, Christopher C., Dalton, James T.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 15.04.2018
• Subjects: adverse effects; androgen receptors; Androgens; Breast cancer; breast neoplasms; Coactivators; cross reaction; Duchenne muscular dystrophy (DMD); evolution; Kinase; ligands; mechanism of action; metabolism; Muscle wasting; osteoporosis; Selective androgen receptor modulators (SARMs); Stress urinary incontinence; testosterone; tissues; Androgens; Selective androgen receptor modulators (SARMs); Kinase; Muscle wasting; Coactivators; Duchenne muscular dystrophy (DMD); Breast cancer; Stress urinary incontinence

The Androgen Receptor (AR), a member of the steroid hormone receptor family, plays important roles in the physiology and pathology of diverse tissues. AR ligands, which include circulating testosterone and locally synthesized dihydrotestosterone, bind to and activate the AR to elicit their effects....