Cyp11b1 Is Induced in the Murine Gonad by Luteinizing Hormone/Human Chorionic Gonadotropin and Involved in the Production of 11-Ketotestosterone, a Major Fish Androgen: Conservation and Evolution of the Androgen Metabolic Pathway

• Published in: Endocrinology (Philadelphia) Vol. 149; no. 4; pp. 1786 - 1792
• Main Authors: Yazawa, Takashi, Uesaka, Miki, Inaoka, Yoshihiko, Mizutani, Tetsuya, Sekiguchi, Toshio, Kajitani, Takashi, Kitano, Takeshi, Umezawa, Akihiro, Miyamoto, Kaoru
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.04.2008
• Subjects: 11-beta-Hydroxysteroid Dehydrogenases - physiology; 11β-Hydroxysteroid dehydrogenase; Adrenal glands; Androgen receptors; Androgens; Androgens - metabolism; Animals; Biological Evolution; Biosynthesis; Cells, Cultured; Chorionic gonadotropin; Chorionic Gonadotropin - pharmacology; Enzyme Induction; Evolutionary conservation; Fish; Fish conservation; Glucocorticoids; Gonadotropins; Gonads; Gonads - metabolism; Hydroxysteroids; Leydig cells; Luteinizing hormone; Luteinizing Hormone - pharmacology; Males; Mammals; Mesenchymal stem cells; Metabolic pathways; Metabolism; Mice; Mice, Inbred C57BL; Ovaries; Pituitary (anterior); Receptors, Androgen - metabolism; Spermatogenesis; Stem cells; Steroid 11-beta-Hydroxylase - biosynthesis; Steroid 11β-hydroxylase; Teleostei; Testosterone; Testosterone - analogs & derivatives; Testosterone - biosynthesis; Theca

We have shown previously that Cyp11b1, an 11β-hydroxylase responsible for glucocorticoid biosynthesis in the adrenal gland, was induced by cAMP in androgen-producing Leydig-like cells derived from mesenchymal stem cells. We found that Cyp11b1 was induced in male Leydig cells, or female theca cells,...