Atrial Fibrillation and Dementia: Exploring the Association, Defining Risks and Improving Outcomes

AF is strongly associated with a spectrum of cranial injuries including stroke and dementia. Dementia risk is seen in patients with and without a prior stroke and includes idiopathic forms of dementia, such as Alzheimer's disease. The initiation, use and efficacy of anticoagulation have been sh...

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Published inArrhythmia & electrophysiology review Vol. 8; no. 1; pp. 8 - 12
Main Authors Bunch, T Jared, Galenko, Oxana, Graves, Kevin G, Jacobs, Victoria, May, Heidi T
Format Journal Article
LanguageEnglish
Published England Radcliffe Medical Education Ltd 01.03.2019
Radcliffe Cardiology
Radcliffe Medical Media
Subjects
Alzheimer's disease
Anticoagulants
Atherosclerosis
Cardiac arrhythmia
Clinical Arrhythmias
Cognitive ability
Dementia
Heart failure
Hemodynamics
Injuries
Ischemia
Mortality
Sinuses
Stroke
Transient ischemic attack
Womens health
anticoagulants
dementia
ageing
cognition
AF
stroke
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Summary:AF is strongly associated with a spectrum of cranial injuries including stroke and dementia. Dementia risk is seen in patients with and without a prior stroke and includes idiopathic forms of dementia, such as Alzheimer's disease. The initiation, use and efficacy of anticoagulation have been shown in multiple observational trials to have an impact on dementia risk. Cerebral hypoperfusion during AF can result in cognitive decline and patients with cranial atherosclerosis may have unique susceptibility. Therapies to carefully control the ventricular rate and catheter ablation have been shown in observational trials to lower dementia risk. There is a need for further research in multiple areas and the observational trials will require prospective trials confirmation. Recent guidelines for AF have advocated the initiation of effective anticoagulation, the treatment of associated disease conditions that may influence the progression of AF and catheter ablation, with long-term management of risk factors to lower risk of dementia.
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Disclosure: TJB is the recipient of research grants from Boston Scientific and Boehringer Ingelheim, but receives no personal compensation. All other authors have no conflicts of interest to declare.
ISSN:2050-3369
2050-3377
DOI:10.15420/aer.2018.75.2