Transient elevation of granulocyte colony-stimulating factor levels in cerebrospinal fluid at the initial stage of aseptic meningitis in children

• Published in: Pediatric research Vol. 37; no. 2; pp. 160 - 164
• Main Authors: FUKUSHIMA, K, ISHIGURO, A, SHIMBO, T
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.02.1995
• Subjects: Adolescent; Animals; Antibodies, Viral - classification; Biological and medical sciences; Cells, Cultured; Cercopithecus aethiops; Cerebrospinal Fluid Proteins - analysis; Cerebrospinal fluid. Meninges. Spinal cord; Child; Child, Preschool; Echovirus Infections - cerebrospinal fluid; Enterovirus B, Human - immunology; Enterovirus B, Human - isolation & purification; Female; Granulocyte Colony-Stimulating Factor - blood; Granulocyte Colony-Stimulating Factor - cerebrospinal fluid; HeLa Cells; Humans; Infant; Macaca fascicularis; Male; Medical sciences; Meningitis, Aseptic - blood; Meningitis, Aseptic - cerebrospinal fluid; Meningitis, Aseptic - virology; Nervous system (semeiology, syndromes); Neurology; Neutrophils - physiology; Vero Cells; Virus Cultivation; Human; Nervous system diseases; Immune response; Cytokine; Granulocyte; Exploration; Infant; Early stage; Cerebrospinal fluid; Granulocyte colony stimulating factor; Polypeptide; Central nervous system disease; Adolescent; Meningitis; Neutrophil; Child

At the early stage of aseptic meningitis, there is a transient increase in neutrophil counts in the cerebrospinal fluid. Some factors in the cerebrospinal fluid might induce migration of neutrophils into the cerebrospinal fluid. Granulocyte colony-stimulating factor (G-CSF) plays an important role,...