Fatty Acids and Membrane Lipidomics in Oncology: A Cross-Road of Nutritional, Signaling and Metabolic Pathways

• Published in: Metabolites Vol. 10; no. 9; p. 345
• Main Authors: Ferreri, Carla, Sansone, Anna, Ferreri, Rosaria, Amézaga, Javier, Tueros, Itziar
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.08.2020; MDPI
• Subjects: Biomarkers; Biosynthesis; Cancer; cancer cell membranes; Carbon; Cell membranes; Desaturase; desaturase enzymes; Enzymatic activity; essential fatty acids; Exosomes; fatty acid biomarker; fatty acid biosynthesis; fatty acid signaling; Fatty acids; Kinases; Lipid metabolism; Lipids; Membranes; Metabolic pathways; Metabolism; Metabolites; Metastases; Nutrition research; Oncology; Polyunsaturated fatty acids; Review; Signal transduction; cancer cell membranes; fatty acid biomarker; fatty acid signaling; inflammation; fatty acid biosynthesis; molecular nutrition; desaturase enzymes; sapienic acid; essential fatty acids; sebaleic acid

Fatty acids are closely involved in lipid synthesis and metabolism in cancer. Their amount and composition are dependent on dietary supply and tumor microenviroment. Research in this subject highlighted the crucial event of membrane formation, which is regulated by the fatty acids’ molecular propert...