Short-Term Caloric Restriction and Subsequent Re-Feeding Compromise Liver Health and Associated Lipid Mediator Signaling in Aged Mice

• Published in: Nutrients Vol. 15; no. 16; p. 3660
• Main Authors: Schädel, Patrick, Wichmann-Costaganna, Mareike, Czapka, Anna, Gebert, Nadja, Ori, Alessandro, Werz, Oliver
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 21.08.2023; MDPI
• Subjects: Animals; Biological response modifiers; Biomarkers; Cytokines; elderly; Ethylenediaminetetraacetic acid; females; Fluorides; Food; health promotion; Inflammation; Instrument industry; interferons; International economic relations; lipids; lipoxygenases; Liver; low calorie diet; Metabolism; Mice; noninsulin-dependent diabetes mellitus; nutrient availability; nutritional intervention; obesity; Peptides; Polyunsaturated fatty acids; proteome; refeeding; secretion; Sodium; Type 2 diabetes; Unsaturated fatty acids; United States; Germany; United States > US

Aging is characterized by alterations in the inflammatory microenvironment, which is tightly regulated by a complex network of inflammatory mediators. Excessive calorie consumption contributes to age- and lifestyle-associated diseases like obesity, type 2 diabetes, cardiovascular disorders, and canc...