In vitro nanoparticle toxicity to rat alveolar cells and coelomocytes from the earthworm Lumbricus rubellus

Abstract Sensitivity of immune cells (coelomocytes) of Lumbricus rubellus earthworms was investigated for exposure to selected nanoparticles, in order to obtain further insight in mechanisms of effects observed after in vivo C60 exposure. In the in vivo study, tissue damage appeared to occur without...

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Published inNanotoxicology Vol. 8; no. 1; pp. 28 - 37
Main Authors van der Ploeg, Merel JC, van den Berg, Johannes HJ, Bhattacharjee, Sourav, de Haan, Laura HJ, Ershov, Dmitry S, Fokkink, Remco G, Zuilhof, Han, Rietjens, Ivonne MCM, van den Brink, Nico W
Format Journal Article
LanguageEnglish
Published England Informa UK, Ltd 01.02.2014
Taylor & Francis
Subjects
Animals
Biocompatibility
Biomedical materials
Buckminsterfullerene
Cell Line
Cell Survival - drug effects
Cytokines - analysis
Cytokines - metabolism
Exposure
fullerene
Fullerenes
Fullerenes - chemistry
Fullerenes - toxicity
immune suppression
Lumbricus rubellus
Macrophages, Alveolar - drug effects
Macrophages, Alveolar - metabolism
Nanoparticles
Nanoparticles - chemistry
Nanoparticles - toxicity
Nanostructure
Oligochaeta - cytology
Oligochaeta - drug effects
Phagocytosis - drug effects
polymer nanoparticle
Polymers - chemistry
Polymers - toxicity
Rats
soil organism
Surgical implants
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Abstract Abstract Sensitivity of immune cells (coelomocytes) of Lumbricus rubellus earthworms was investigated for exposure to selected nanoparticles, in order to obtain further insight in mechanisms of effects observed after in vivo C60 exposure. In the in vivo study, tissue damage appeared to occur without accompanying increased immune responses. Coelomocytes exposed in vitro to C60 showed no decrease of their cellular viability, but demonstrated a decrease in gene expression of the cytokine-like protein CCF-1, indicating immunosuppression. Experiments with NR8383 rat macrophage cells and tri-block copolymer nanoparticles were used to compare sensitivity and to demonstrate the usefulness of coelomocytes as a test system for nano-immunotoxicity, respectively. Overall, the results imply that sensitivity towards nanoparticles differs between cell types and nanoparticles. Moreover, this study indicates that injuries in absence of an immune response, observed after in vivo C60 exposure in our earlier work, are caused by immunosuppression rather than coelomocyte mortality.
AbstractList Sensitivity of immune cells (coelomocytes) of Lumbricus rubellus earthworms was investigated for exposure to selected nanoparticles, in order to obtain further insight in mechanisms of effects observed after in vivo C 60 exposure. In the in vivo study, tissue damage appeared to occur without accompanying increased immune responses. Coelomocytes exposed in vitro to C 60 showed no decrease of their cellular viability, but demonstrated a decrease in gene expression of the cytokine-like protein CCF-1, indicating immunosuppression. Experiments with NR8383 rat macrophage cells and tri-block copolymer nanoparticles were used to compare sensitivity and to demonstrate the usefulness of coelomocytes as a test system for nano-immunotoxicity, respectively. Overall, the results imply that sensitivity towards nanoparticles differs between cell types and nanoparticles. Moreover, this study indicates that injuries in absence of an immune response, observed after in vivo C 60 exposure in our earlier work, are caused by immunosuppression rather than coelomocyte mortality.
Abstract Sensitivity of immune cells (coelomocytes) of Lumbricus rubellus earthworms was investigated for exposure to selected nanoparticles, in order to obtain further insight in mechanisms of effects observed after in vivo C60 exposure. In the in vivo study, tissue damage appeared to occur without accompanying increased immune responses. Coelomocytes exposed in vitro to C60 showed no decrease of their cellular viability, but demonstrated a decrease in gene expression of the cytokine-like protein CCF-1, indicating immunosuppression. Experiments with NR8383 rat macrophage cells and tri-block copolymer nanoparticles were used to compare sensitivity and to demonstrate the usefulness of coelomocytes as a test system for nano-immunotoxicity, respectively. Overall, the results imply that sensitivity towards nanoparticles differs between cell types and nanoparticles. Moreover, this study indicates that injuries in absence of an immune response, observed after in vivo C60 exposure in our earlier work, are caused by immunosuppression rather than coelomocyte mortality.
Sensitivity of immune cells (coelomocytes) of Lumbricus rubellus earthworms was investigated for exposure to selected nanoparticles, in order to obtain further insight in mechanisms of effects observed after in vivo C sub(60) exposure. In the in vivo study, tissue damage appeared to occur without accompanying increased immune responses. Coelomocytes exposed in vitro to C sub(60) showed no decrease of their cellular viability, but demonstrated a decrease in gene expression of the cytokinelike protein CCF-1, indicating immunosuppression. Experiments with NR8383 rat macrophage cells and tri-block copolymer nanoparticles were used to compare sensitivity and to demonstrate the usefulness of coelomocytes as a test system for nano-immunotoxicity, respectively. Overall, the results imply that sensitivity towards nanoparticles differs between cell types and nanoparticles. Moreover, this study indicates that injuries in absence of an immune response, observed after in vivo C sub(60) exposure in our earlier work, are caused by immunosuppression rather than coelomocyte mortality.
Sensitivity of immune cells (coelomocytes) of Lumbricus rubellus earthworms was investigated for exposure to selected nanoparticles, in order to obtain further insight in mechanisms of effects observed after in vivo C60 exposure. In the in vivo study, tissue damage appeared to occur without accompanying increased immune responses. Coelomocytes exposed in vitro to C60 showed no decrease of their cellular viability, but demonstrated a decrease in gene expression of the cytokine-like protein CCF-1, indicating immunosuppression. Experiments with NR8383 rat macrophage cells and tri-block copolymer nanoparticles were used to compare sensitivity and to demonstrate the usefulness of coelomocytes as a test system for nano-immunotoxicity, respectively. Overall, the results imply that sensitivity towards nanoparticles differs between cell types and nanoparticles. Moreover, this study indicates that injuries in absence of an immune response, observed after in vivo C60 exposure in our earlier work, are caused by immunosuppression rather than coelomocyte mortality.
Author de Haan, Laura HJ
van den Berg, Johannes HJ
Bhattacharjee, Sourav
Ershov, Dmitry S
van der Ploeg, Merel JC
Rietjens, Ivonne MCM
van den Brink, Nico W
Fokkink, Remco G
Zuilhof, Han
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/23102209$$D View this record in MEDLINE/PubMed
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Snippet Abstract Sensitivity of immune cells (coelomocytes) of Lumbricus rubellus earthworms was investigated for exposure to selected nanoparticles, in order to...
Sensitivity of immune cells (coelomocytes) of Lumbricus rubellus earthworms was investigated for exposure to selected nanoparticles, in order to obtain further...
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StartPage 28
SubjectTerms Animals
Biocompatibility
Biomedical materials
Buckminsterfullerene
Cell Line
Cell Survival - drug effects
Cytokines - analysis
Cytokines - metabolism
Exposure
fullerene
Fullerenes
Fullerenes - chemistry
Fullerenes - toxicity
immune suppression
Lumbricus rubellus
Macrophages, Alveolar - drug effects
Macrophages, Alveolar - metabolism
Nanoparticles
Nanoparticles - chemistry
Nanoparticles - toxicity
Nanostructure
Oligochaeta - cytology
Oligochaeta - drug effects
Phagocytosis - drug effects
polymer nanoparticle
Polymers - chemistry
Polymers - toxicity
Rats
soil organism
Surgical implants
Title In vitro nanoparticle toxicity to rat alveolar cells and coelomocytes from the earthworm Lumbricus rubellus
URI https://www.tandfonline.com/doi/abs/10.3109/17435390.2012.744857
https://www.ncbi.nlm.nih.gov/pubmed/23102209
https://search.proquest.com/docview/1639990072
https://search.proquest.com/docview/1660085584
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