Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-Flight Mass Spectrometry

• Published in: Cancer research (Chicago, Ill.) Vol. 69; no. 11; pp. 4918 - 4925
• Main Authors: Hirayama, Akiyoshi, Kami, Kenjiro, Sugimoto, Masahiro, Sugawara, Maki, Toki, Naoko, Onozuka, Hiroko, Kinoshita, Taira, Saito, Norio, Ochiai, Atsushi, Tomita, Masaru, Esumi, Hiroyasu, Soga, Tomoyoshi
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.06.2009
• Subjects: Antineoplastic agents; Biological and medical sciences; Citric Acid Cycle - physiology; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; Electrophoresis, Capillary - methods; Female; Gastroenterology. Liver. Pancreas. Abdomen; Glycolysis - physiology; Humans; Male; Mass Spectrometry - methods; Medical sciences; Metabolome; Metabolomics - methods; Models, Biological; Pharmacology. Drug treatments; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; Capillary electrophoresis; Metabolome; Exploration; Malignant tumor; Microenvironment; Stomach cancer; Colonic disease; Colon cancer; Digestive diseases; Intestinal disease; Mass spectrometry; Cancer; Gastric disease; Quantitative analysis

Most cancer cells predominantly produce energy by glycolysis rather than oxidative phosphorylation via the tricarboxylic acid (TCA) cycle, even in the presence of an adequate oxygen supply (Warburg effect). However, little has been reported regarding the direct measurements of global metabolites in...