Physical dissection of the CCAAT/enhancer-binding protein α in regulating the mouse amelogenin gene

• Published in: Biochemical and biophysical research communications Vol. 354; no. 1; pp. 56 - 61
• Main Authors: Xu, Yucheng, Zhou, Yan Larry, Erickson, Robin L., MacDougald, Ormond A., Snead, Malcolm L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.03.2007
• Subjects: Ameloblasts - physiology; Amelogenin; Amelogenin - genetics; Animals; C/EBPα; CCAAT-Enhancer-Binding Protein-alpha - genetics; Cell Line; Gene Expression Regulation - genetics; Gene regulation; Mice; Msx2; Promoter; Promoter Regions, Genetic - genetics; Protein–protein interactions; Structure-Activity Relationship; Tooth formation; Transcriptional Activation - genetics; Promoter; Tooth formation; C/EBPα; Protein–protein interactions; Msx2; Gene regulation; Amelogenin

The amelogenin gene is tightly regulated at the temporal and spatial level in accord with the developmental requirement for tooth formation. Previous studies have shown that CCAAT/enhancer-binding protein α (C/EBPα) is a transactivator of the mouse X-chromosomal amelogenin gene. C/EBPα contains four...