Revisiting the role of Wnt/β-catenin signaling in prostate cancer
The androgen receptor (AR) is a widely accepted therapeutic target in prostate cancer and multiple studies indicate that the AR and Wnt/β-catenin pathways intersect. Recent genome-wide analysis of prostate cancer metastases illustrate the importance of the Wnt/β-catenin pathway in prostate cancer an...
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| Published in | Molecular and cellular endocrinology Vol. 462; no. Pt A; pp. 3 - 8 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier B.V
15.02.2018
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| Abstract | The androgen receptor (AR) is a widely accepted therapeutic target in prostate cancer and multiple studies indicate that the AR and Wnt/β-catenin pathways intersect. Recent genome-wide analysis of prostate cancer metastases illustrate the importance of the Wnt/β-catenin pathway in prostate cancer and compel us to reexamine the interaction of the AR and Wnt/β-catenin signaling pathways. This review includes newer areas of interest such as non-canonical Wnt signaling and the role of Wnts in prostate cancer stem cells. The effort to develop Wnt modulating therapeutics, both biologics and small molecules, is also discussed.
•Description of interactions of the Wnt/β-catenin and AR signaling in prostate cancer.•The interaction may be synergistic or opposing depending on context.•Prostate cancer stem cells and non-canonical Wnt signaling in PCa also discussed.•The status of Wnt modulating therapeutics in relation to cancer is detailed. |
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| AbstractList | The androgen receptor (AR) is a widely accepted therapeutic target in prostate cancer and multiple studies indicate that the AR and Wnt/β-catenin pathways intersect. Recent genome-wide analysis of prostate cancer metastases illustrate the importance of the Wnt/β-catenin pathway in prostate cancer and compel us to reexamine the interaction of the AR and Wnt/β-catenin signaling pathways. This review includes newer areas of interest such as non-canonical Wnt signaling and the role of Wnts in prostate cancer stem cells. The effort to develop Wnt modulating therapeutics, both biologics and small molecules, is also discussed. The androgen receptor (AR) is a widely accepted therapeutic target in prostate cancer and multiple studies indicate that the AR and Wnt/β-catenin pathways intersect. Recent genome-wide analysis of prostate cancer metastases illustrate the importance of the Wnt/β-catenin pathway in prostate cancer and compel us to reexamine the interaction of the AR and Wnt/β-catenin signaling pathways. This review includes newer areas of interest such as non-canonical Wnt signaling and the role of Wnts in prostate cancer stem cells. The effort to develop Wnt modulating therapeutics, both biologics and small molecules, is also discussed. •Description of interactions of the Wnt/β-catenin and AR signaling in prostate cancer.•The interaction may be synergistic or opposing depending on context.•Prostate cancer stem cells and non-canonical Wnt signaling in PCa also discussed.•The status of Wnt modulating therapeutics in relation to cancer is detailed. The androgen receptor (AR) is a widely accepted therapeutic target in prostate cancer and multiple studies indicate that the AR and Wnt/β-catenin pathways intersect. Recent genome-wide analysis of prostate cancer metastases illustrate the importance of the Wnt/β-catenin pathway in prostate cancer and compel us to reexamine the interaction of the AR and Wnt/β-catenin signaling pathways. This review includes newer areas of interest such as non-canonical Wnt signaling and the role of Wnts in prostate cancer stem cells. The effort to develop Wnt modulating therapeutics, both biologics and small molecules, is also discussed.The androgen receptor (AR) is a widely accepted therapeutic target in prostate cancer and multiple studies indicate that the AR and Wnt/β-catenin pathways intersect. Recent genome-wide analysis of prostate cancer metastases illustrate the importance of the Wnt/β-catenin pathway in prostate cancer and compel us to reexamine the interaction of the AR and Wnt/β-catenin signaling pathways. This review includes newer areas of interest such as non-canonical Wnt signaling and the role of Wnts in prostate cancer stem cells. The effort to develop Wnt modulating therapeutics, both biologics and small molecules, is also discussed. |
| Author | Logan, Susan K. Schneider, Jeffrey A. |
| Author_xml | – sequence: 1 givenname: Jeffrey A. surname: Schneider fullname: Schneider, Jeffrey A. organization: Departments of Urology, Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, United States – sequence: 2 givenname: Susan K. surname: Logan fullname: Logan, Susan K. email: susan.logan@nyumc.org organization: Departments of Urology, Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, United States |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28189566$$D View this record in MEDLINE/PubMed |
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| Keywords | β-catenin Wnt signaling Prostate cancer Androgen receptor |
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| SubjectTerms | Androgen receptor androgen receptors Animals genome-wide association study Humans Male metastasis Molecular Targeted Therapy Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Prostate cancer prostatic neoplasms Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - therapy Receptors, Androgen - metabolism Signal Transduction stem cells therapeutics Wnt signaling Wnt Signaling Pathway β-catenin |
| Title | Revisiting the role of Wnt/β-catenin signaling in prostate cancer |
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