Bioactive collagen-grafted poly-L-lactic acid nanofibrous membrane for cartilage tissue engineering

• Published in: Journal of nanoscience and nanotechnology Vol. 10; no. 8; p. 5393
• Main Authors: Chen, Jyh-Ping, Li, Sheng-Feng, Chiang, Yi-Ping
• Format: Journal Article
• Language: English
• Published: United States 01.08.2010
• Subjects: Animals; Cartilage - cytology; Cartilage - growth & development; Cell Differentiation; Cells, Cultured; Chondrocytes - metabolism; Collagen - chemistry; Lactic Acid - chemistry; Microscopy, Confocal; Microscopy, Electron, Scanning; Nanofibers - chemistry; Polyesters; Polymers - chemistry; Rabbits; Tissue Engineering - methods; Tissue Scaffolds - chemistry

Biodegradable nanofibrous membrane was prepared from poly-L-lactic acid by electrospinning and used as a scaffold for cartilage tissue engineering. Operating parameters during the electrospinning process were studied in terms of their influences on fiber diameter, membrane porosity and pore size. In...